About Enhancer
| Enhancer ID: | E_00392 |
| Species: | Homo sapiens |
| Position : | chr3:128603426-128604425   |
| Year: | 2021 |
| Title: | The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 34584081 |
| MONDO: | MONDO:0018874 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | 3) AML blasts |
| Cell Type: | myeloid leukemia blast cell |
| Cell Ontology ID: | CL:0000947 |
| Experiment Type: | Enhancer hijacking; TF binding; chromatin-state and structural-variant validation |
| High Throughput Method: | H3K27ac ChIP-seq; hematopoietic TF ChIP-seq; structural-variant mapping; RNA-seq |
| Low Throughput Method: | FISH; breakpoint PCR; RT-qPCR; CRISPR-Cas9 |
About Target Gene
| Target gene : | MECOM |
About TF
| TF name : | GATA2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA2 | AP-1 transcription factor network | pid | 71 |
| GATA2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA2 | HIF-1-alpha transcription factor network | pid | 67 |
| GATA2 | IL3 | netpath | 84 |
| GATA2 | Regulation of Androgen receptor activity | pid | 54 |
| GATA2 | Signaling events mediated by HDAC Class I | pid | 89 |
| GATA2 | Signaling events mediated by HDAC Class II | pid | 58 |
| GATA2 | Hs_Apoptosis_WP254_88977 | wikipathways | 31 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00340 | chr3:128603426-128604425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00418 | chr3:128603426-128604425 | blood | CD34-positive hematopoietic stem/progenitor cell | NA |
| E_03951 | chr3:128603821-128604120 | bone marrow | myeloid leukemia cell | acute myeloid leukemia with inv(3)(q21.3q26.2)/t(3;3)(q21.3;q26.2) |
| E_03979 | chr3:128603821-128604120 | bone marrow | myeloid leukemia cell | acute myeloid leukemia with inv(3)(q21.3q26.2)/t(3;3)(q21.3;q26.2) |
| E_04324 | chr3:128603821-128604120 | bone marrow | hematopoietic stem/progenitor cell | acute myeloid leukemia with inv(3)(q21.3q26.2)/t(3;3)(q21.3;q26.2) |
Expression of Target Genes for the Enhancer