About Enhancer
| Enhancer ID: | E_00275 |
| Species: | Homo sapiens |
| Position : | chr22:42411333-42413643   |
| Year: | 2015 |
| Title: | Functional characterization of CYP2D6 enhancer polymorphisms. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 25381333 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | Human Primary Hepatocytes |
| Cell Type: | hepatocyte |
| Cell Ontology ID: | CL:0000182 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Chromatin interaction assay; Endogenous enhancer perturbation; Genetic-variant functional analysis |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; CRISPR-Cas9 targeted editing/deletion; ChIP-qPCR/ChIP; 4C; RT-qPCR/qPCR |
About Target Gene
| Target gene : | CYP2D6 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
9 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00639 | chr22:42411544-42415106 | liver | hepatocyte | NA |
| E_00151 | chr22:42411693-42414130 | liver | epithelial cell | NA |
| E_00152 | chr22:42411693-42414130 | liver | NA | NA |
| E_00274 | chr22:42411693-42414130 | liver | hepatocyte | NA |
| E_00382 | chr22:42411693-42414130 | liver | hepatocyte | NA |
| E_00412 | chr22:42411693-42414130 | liver | hepatocyte | NA |
| E_00413 | chr22:42411693-42414130 | liver | hepatocyte | NA |
| E_00414 | chr22:42411693-42414130 | liver | hepatocyte | NA |
| E_00640 | chr22:42411769-42414470 | liver | hepatocyte | NA |
Expression of Target Genes for the Enhancer