About Enhancer
| Enhancer ID: | E_00193 |
| Species: | Homo sapiens |
| Position : | chr2:18910338-18911438   |
| Year: | 2025 |
| Title: | Systematic decoding of functional enhancer connectomes and risk variants in human glioma. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | malignant glioma |
| PMID: | 40830415 |
| MONDO: | MONDO:0100342 |
| Tissue: | brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | U-251MG |
| CVCL ID: | CVCL_0021 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; chromatin interaction assay; functional perturbation assay; Endogenous enhancer perturbation; Chromatin-state profiling; Disease-variant functional analysis |
| High Throughput Method: | H3K27ac HiChIP; H3K27ac ChIP-seq; RNA-seq; pooled CRISPRi screening; HiChIP; pooled CRISPRi screen |
| Low Throughput Method: | CRISPRi enhancer repression; 3C-qPCR; RT-qPCR; CRISPR-Cas9 endogenous deletion/editing; CRISPRi |
About Target Gene
| Target gene : | LAPTM4A |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
7 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00194 | chr2:18910338-18911438 | brain | malignant cell | malignant glioma |
| E_00195 | chr2:18910338-18911438 | brain | malignant cell | malignant glioma |
| E_00196 | chr2:18910338-18911438 | brain | malignant cell | malignant glioma |
| E_00383 | chr2:18910338-18911438 | brain | malignant cell | malignant glioma |
| E_00384 | chr2:18910338-18911438 | brain | malignant cell | malignant glioma |
| E_00385 | chr2:18910338-18911438 | brain | malignant cell | malignant glioma |
| E_00386 | chr2:18910338-18911438 | brain | malignant cell | malignant glioma |
Expression of Target Genes for the Enhancer