About Enhancer
| Enhancer ID: | E_00183 |
| Species: | Homo sapiens |
| Position : | chr8:129582024-129582425   |
| Year: | 2021 |
| Title: | The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 34584081 |
| MONDO: | MONDO:0018874 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | 8)(q26 |
| Cell Type: | myeloid leukemia blast cell |
| Cell Ontology ID: | CL:0000947 |
| Experiment Type: | Enhancer hijacking; TF binding assay; chromatin interaction assay; functional enhancer deletion |
| High Throughput Method: | 3q-seq/targeted structural-variant sequencing; H3K27ac ChIP-seq; ATAC-seq; TF/CTCF/cohesin ChIP-seq; 4C-seq; RNA-seq |
| Low Throughput Method: | CRISPR-Cas9 t(3; 8) engineering; enhancer-module deletion; RT-qPCR; Western blot; flow cytometry; PCR; FISH; CRISPR-Cas9 |
About Target Gene
| Target gene : | MECOM |
About TF
| TF name : | RUNX1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| RUNX1 | AndrogenReceptor | netpath | 167 |
| RUNX1 | Organic cation transport | reactome | 9 |
| RUNX1 | RANKL | netpath | 84 |
| RUNX1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| RUNX1 | TGF_beta_Receptor | netpath | 220 |
| RUNX1 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| RUNX1 | Pathways in cancer | kegg | 321 |
| RUNX1 | Chronic myeloid leukemia | kegg | 69 |
| RUNX1 | Acute myeloid leukemia | kegg | 53 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
47 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03876 | chr8:126650000-129950000 | colon | malignant cell | NA |
| E_02303 | chr8:129440000-129740000 | kidney | malignant cell | rhabdoid tumor |
| E_00764 | chr8:129581780-129583797 | blood | malignant cell | NA |
| E_00804 | chr8:129581780-129583797 | blood | malignant cell | NA |
| E_00057 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00058 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00059 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00060 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00061 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00062 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00161 | chr8:129582024-129582425 | bone marrow | malignant cell | acute myeloid leukemia with t(3; 8)(q26; q24) MECOM rearrangement |
| E_00162 | chr8:129582024-129582425 | blood | malignant cell | acute myeloid leukemia |
| E_00163 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00164 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00165 | chr8:129582024-129582425 | bone marrow | malignant cell | acute myeloid leukemia with t(3; 8)(q26; q24) MECOM rearrangement |
| E_00166 | chr8:129582024-129582425 | blood | malignant cell | acute myeloid leukemia |
| E_00167 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00168 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00169 | chr8:129582024-129582425 | bone marrow | malignant cell | acute myeloid leukemia with t(3; 8)(q26; q24) MECOM rearrangement |
| E_00170 | chr8:129582024-129582425 | blood | malignant cell | acute myeloid leukemia |
| E_00171 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00172 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00173 | chr8:129582024-129582425 | bone marrow | malignant cell | acute myeloid leukemia with t(3; 8)(q26; q24) MECOM rearrangement |
| E_00174 | chr8:129582024-129582425 | blood | malignant cell | acute myeloid leukemia |
| E_00175 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00176 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00177 | chr8:129582024-129582425 | bone marrow | malignant cell | acute myeloid leukemia with t(3; 8)(q26; q24) MECOM rearrangement |
| E_00178 | chr8:129582024-129582425 | blood | malignant cell | acute myeloid leukemia |
| E_00179 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00180 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00181 | chr8:129582024-129582425 | bone marrow | malignant cell | acute myeloid leukemia with t(3; 8)(q26; q24) MECOM rearrangement |
| E_00182 | chr8:129582024-129582425 | blood | malignant cell | acute myeloid leukemia |
| E_00184 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00247 | chr8:129582024-129582425 | blood | CD34-positive hematopoietic stem/progenitor cell | NA |
| E_00248 | chr8:129582024-129582425 | blood | CD34-positive hematopoietic stem/progenitor cell | NA |
| E_00249 | chr8:129582024-129582425 | blood | CD34-positive hematopoietic stem/progenitor cell | NA |
| E_00250 | chr8:129582024-129582425 | blood | CD34-positive hematopoietic stem/progenitor cell | NA |
| E_00251 | chr8:129582024-129582425 | blood | CD34-positive hematopoietic stem/progenitor cell | NA |
| E_00252 | chr8:129582024-129582425 | blood | CD34-positive hematopoietic stem/progenitor cell | NA |
| E_00398 | chr8:129582024-129582425 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_00399 | chr8:129582024-129582425 | blood | myeloid leukemia cell | acute myeloid leukemia |
| E_00427 | chr8:129582024-129582425 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_00428 | chr8:129582024-129582425 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_00429 | chr8:129582024-129582425 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_00430 | chr8:129582024-129582425 | blood | myeloid leukemia cell | acute myeloid leukemia |
| E_00431 | chr8:129582024-129582425 | blood | myeloid leukemia cell | acute myeloid leukemia |
| E_00432 | chr8:129582024-129582425 | blood | myeloid leukemia cell | acute myeloid leukemia |
Expression of Target Genes for the Enhancer