About Enhancer
| Enhancer ID: | E_00150 |
| Species: | Homo sapiens |
| Position : | chr12:25538591-25539583   |
| Year: | 2020 |
| Title: | Noncoding Variants Connect Enhancer Dysregulation with Nuclear Receptor Signaling in Hematopoietic Malignancies. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | hematopoietic malignancy |
| PMID: | 32188707 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | MKPL-1 |
| CVCL ID: | CVCL_2116 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; functional perturbation assay; TF binding assay; Disease-variant functional analysis |
| High Throughput Method: | targeted CRE resequencing; pooled enCRISPRi/enCRISPRa screen; H3K27ac ChIP-seq; ATAC-seq; chromatin interaction profiling |
| Low Throughput Method: | individual enCRISPRi/enCRISPRa; CRISPR-Cas9 enhancer deletion; enhancer luciferase reporter assay; variant knock-in; ChIP-qPCR; RT-qPCR; EMSA |
About Target Gene
| Target gene : | KRAS |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Expression of Target Genes for the Enhancer