About Enhancer
| Enhancer ID: | E_00053 |
| Species: | Homo sapiens |
| Position : | chr17:38065500-38067500   |
| Year: | 2016 |
| Title: | 17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | asthma |
| PMID: | 27848966 |
| MONDO: | MONDO:0004979 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | HuT 78 |
| CVCL ID: | CVCL_0337 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay; Chromatin interaction assay; Disease-variant functional analysis |
| High Throughput Method: | ATAC-seq, ChIP-seq, 4C-seq, RNA-seq, DNase-seq; 4C-seq |
| Low Throughput Method: | ChIP-RT-qPCR, Luciferase reporter assay, RT-RT-qPCR, siRNA knockdown, EMSA; 4C |
About Target Gene
| Target gene : | ORMDL3 |
About TF
| TF name : | CTCF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00424 | chr17:38065000-38068000 | blood | CD4-positive T cell | NA |
Expression of Target Genes for the Enhancer