About Enhancer
| Enhancer ID: | E_00044 |
| Species: | Homo sapiens |
| Position : | chr11:8289240-8289522   |
| Year: | 2017 |
| Title: | APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 28260788 |
| MONDO: | MONDO:0004963 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Jurkat |
| CVCL ID: | CVCL_0065 |
| Cell Type: | T cell |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Chromatin interaction assay; Endogenous enhancer perturbation |
| High Throughput Method: | H3K27ac ChIP-seq; RUNX1 ChIP-seq; polyA RNA-seq; ChIA-PET |
| Low Throughput Method: | Luciferase reporter assay using 585-bp wild-type and mutant enhancer fragments; Sanger sequencing; qRT-PCR; Site-directed/motif mutagenesis |
About Target Gene
| Target gene : | LMO1 |
About TF
| TF name : | RUNX1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| RUNX1 | AndrogenReceptor | netpath | 167 |
| RUNX1 | Organic cation transport | reactome | 9 |
| RUNX1 | RANKL | netpath | 84 |
| RUNX1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| RUNX1 | TGF_beta_Receptor | netpath | 220 |
| RUNX1 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| RUNX1 | Pathways in cancer | kegg | 321 |
| RUNX1 | Chronic myeloid leukemia | kegg | 69 |
| RUNX1 | Acute myeloid leukemia | kegg | 53 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
3 found
Expression of Target Genes for the Enhancer