About Enhancer
| Enhancer ID: | E_00043 |
| Species: | Homo sapiens |
| Position : | chr11:8289240-8289522   |
| Year: | 2017 |
| Title: | APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 28260788 |
| MONDO: | MONDO:0004963 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Jurkat |
| CVCL ID: | CVCL_0065 |
| Cell Type: | T cell |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Chromatin interaction assay; Endogenous enhancer perturbation |
| High Throughput Method: | H3K27ac ChIP-seq; GATA3 ChIP-seq; polyA RNA-seq; ChIA-PET |
| Low Throughput Method: | Luciferase reporter assay using 585-bp wild-type and mutant enhancer fragments; Sanger sequencing; qRT-PCR; Site-directed/motif mutagenesis |
About Target Gene
| Target gene : | LMO1 |
About TF
| TF name : | GATA3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA3 | C-MYB transcription factor network | pid | 87 |
| GATA3 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| GATA3 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA3 | Glucocorticoid receptor regulatory network | pid | 85 |
| GATA3 | IL27-mediated signaling events | pid | 26 |
| GATA3 | Notch signaling pathway | pid | 58 |
| GATA3 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| GATA3 | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| GATA3 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
3 found
Expression of Target Genes for the Enhancer