About Enhancer
| Enhancer ID: | E_00020 |
| Species: | Homo sapiens |
| Position : | chr20:63680793-63682109   |
| Year: | 2025 |
| Title: | Systematic decoding of functional enhancer connectomes and risk variants in human glioma. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | malignant glioma |
| PMID: | 40830415 |
| MONDO: | MONDO:0100342 |
| Tissue: | brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | U-251MG |
| CVCL ID: | CVCL_0021 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF binding assay; chromatin interaction assay; functional perturbation assay; Endogenous enhancer perturbation; Chromatin-state profiling; Disease-variant functional analysis |
| High Throughput Method: | H3K27ac HiChIP; H3K27ac ChIP-seq; RNA-seq; GWAS variant mapping; pooled CRISPRi screening; HiChIP; pooled CRISPRi screen |
| Low Throughput Method: | ChIP-qPCR; CRISPR-Cas9 enhancer deletion; base editing; 3C-qPCR; dCas9-CRISPRa; RT-qPCR; luciferase reporter assay; CRISPR-Cas9 endogenous deletion/editing; CRISPRi |
About Target Gene
| Target gene : | SOX18 |
About TF
| TF name : | MEIS1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MEIS1 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00153 | chr20:63680793-63682109 | brain | malignant cell | malignant glioma |
Expression of Target Genes for the Enhancer