About Enhancer
| Enhancer ID: | E_00018 |
| Species: | Homo sapiens |
| Position : | chr10:46073046-46074046   |
| Year: | 2025 |
| Title: | Integrated Omics and Multicohort Analyses Identify an Enhancer Variant Linking Ferroptosis to Precision Therapy in Prostate Cancer. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | prostate cancer |
| PMID: | 40758996 |
| MONDO: | MONDO:0008315 |
| Tissue: | prostate gland |
| Tissue Ontology ID: | UBERON:0002367 |
| Cell Source: | DU145 |
| CVCL ID: | CVCL_0105 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Chromatin interaction assay; Functional perturbation assay; Endogenous enhancer perturbation; Disease-variant functional analysis |
| High Throughput Method: | ATAC-seq; RNA-seq; Hi-C |
| Low Throughput Method: | Luciferase reporter assay; ChIP-qPCR; 3C-qPCR; CRISPR knockout; CRISPRi; RT-qPCR; CRISPR-Cas9 endogenous deletion/editing; Allele-specific reporter assay |
About Target Gene
| Target gene : | NCOA4 |
About TF
| TF name : | ZNF384 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Expression of Target Genes for the Enhancer