About Enhancer
| Enhancer ID: | E_00004 |
| Species: | Homo sapiens |
| Position : | chr13:73958961-73960160   |
| Year: | 2025 |
| Title: | Characterization of cis-regulatory elements and functional variants in colorectal cancer using epigenomics and CRISPRi screenings. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal adenocarcinoma |
| PMID: | 40854986 |
| MONDO: | MONDO:0005008 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | HCT 116 |
| CVCL ID: | CVCL_0291 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Dual-luciferase reporter assay, CRISPR-Cas9 base editing, CRISPRi silencing, 3C chromatin capture, ChIP-qPCR |
| High Throughput Method: | ATAC-seq; H3K27ac ChIP-seq; Hi-C; RNA-seq; ABC model prediction; GWAS summary statistics |
| Low Throughput Method: | qRT-PCR; EMSA supershift assay; DNase I footprinting, cell proliferation assay, colony formation assay, mouse xenograft tumor assay; CRISPRi |
About Target Gene
| Target gene : | KLF5 |
About TF
| TF name : | FOXP1 |
About Regulatory State
| Regulatory State : | Repressed |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
7 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00944 | chr13:73880413-74042621 | lung | malignant cell | lung adenocarcinoma |
| E_00945 | chr13:73880413-74042621 | lung | malignant cell | lung adenocarcinoma |
| E_00978 | chr13:73880690-73990596 | NA | malignant cell | Esophageal Carcinoma |
| E_01079 | chr13:73941969-74004429 | head and neck epithelium | malignant cell | head and neck squamous cell carcinoma |
| E_00005 | chr13:73958961-73960160 | colon | malignant cell | colorectal adenocarcinoma |
| E_00006 | chr13:73958961-73960160 | colon | malignant cell | colorectal adenocarcinoma |
| E_00007 | chr13:73958961-73960160 | colon | malignant cell | colorectal adenocarcinoma |
Expression of Target Genes for the Enhancer