About Enhancer
| Enhancer ID: | E_00003 |
| Species: | Homo sapiens |
| Position : | chr2:127082600-127082962   |
| Year: | 2019 |
| Title: | Brain cell type-specific enhancer-promoter interactome maps and disease-risk association. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Alzheimer disease |
| PMID: | 31727856 |
| MONDO: | MONDO:0004975 |
| Tissue: | brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | hPSC-derived microglia |
| Cell Type: | Brain microglia |
| Experiment Type: | CRISPR-Cas9 loss-of-function deletion, PLAC-seq chromatin interaction, ChIP-qPCR |
| High Throughput Method: | ATAC-seq; H3K27ac ChIP-seq; H3K4me3 ChIP-seq; PLAC-seq; RNA-seq; LDSC GWAS heritability analysis |
| Low Throughput Method: | qRT-PCR, dual-luciferase reporter,; RNA FISH super-resolution imaging, subcellular fractionation, xenograft in vivo tumor assay; Flow cytometry |
About Target Gene
| Target gene : | BIN1 |
About TF
| TF name : | SPI1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SPI1 | C-MYB transcription factor network | pid | 87 |
| SPI1 | ERK cascade ( FGF8 signaling (Mouse) ) | inoh | 17 |
| SPI1 | ERK cascade ( FGF8 signaling (Xenopus) ) | inoh | 17 |
| SPI1 | FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) | inoh | 20 |
| SPI1 | FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) | inoh | 18 |
| SPI1 | Glucocorticoid receptor regulatory network | pid | 85 |
| SPI1 | IL4-mediated signaling events | pid | 66 |
| SPI1 | IL4 | netpath | 75 |
| SPI1 | Interleukin signaling pathway | panther | 86 |
| SPI1 | RANKL | netpath | 84 |
| SPI1 | Regulation of retinoblastoma protein | pid | 67 |
| SPI1 | Validated targets of C-MYC transcriptional repression | pid | 63 |
| SPI1 | Pathways in cancer | kegg | 321 |
| SPI1 | Acute myeloid leukemia | kegg | 53 |
| SPI1 | Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016 | wikipathways | 26 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00187 | chr2:127082600-127082962 | brain | microglial cell | Alzheimer disease |
Expression of Target Genes for the Enhancer