SEdb 2.0
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  2. Super-enhancer search result of gene-based

Gene overview

Strategies/Algorithm: proximal Ensembl ID: ENSG00000134250
Gene: NOTCH2 Gene type: protein_coding
Strand: - External links:
Genomic region: chr1:119911553-120100779 Genome Browser:

Super-enhancer search result of gene-based

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SE ID SE Region Sample ID Tissue type Biosample name SE rank Element Common SNP eQTL Risk SNP TFBS CRISPR Cas9 Gene
SE_02_010400080 chr1:120074785-120146014 Sample_02_0104 Blood neutrophils 80 10 1487 83 0 246 0 NOTCH2
SE_02_000300099 chr1:120079610-120119472 Sample_02_0003 Mammary gland MCF-7_10Gygamma_5h 99 7 907 48 0 162 0 NOTCH2
SE_02_026900084 chr1:120079957-120088887 Sample_02_0269 Kidney HK-2 84 3 195 12 0 29 0 NOTCH2
SE_02_099100641 chr1:120080238-120145754 Sample_02_0991 Breast cancer cell line lung metastatic variant MDA-MB-231 LM2 641 12 1403 79 0 228 0 SEC22B,NOTCH2
SE_02_122401074 chr1:120080249-120153386 Sample_02_1224 Bone marrow normal plasma cell 1074 18 1560 92 0 229 0 SEC22B,NOTCH2
SE_01_005800312 chr1:120080346-120125125 Sample_01_0058 Prostate PC-3 312 5 977 52 0 165 0 NOTCH2
SE_01_004800179 chr1:120080439-120083022 Sample_01_0048 Peripheral blood MM.1S 179 1 46 3 0 9 0 NOTCH2
SE_01_005500461 chr1:120080496-120125267 Sample_01_0055 Haematopoietic and lymphoid tissue OCI-LY7 461 5 977 52 0 168 0 NOTCH2
SE_02_072900297 chr1:120080888-120142947 Sample_02_0729 Lymphoma I10_Mantle cell lymphoma tissue_THZ1 297 23 1322 75 0 210 0 SEC22B,NOTCH2
SE_01_002000230 chr1:120083191-120125569 Sample_01_0020 Blood B-cell 230 6 935 50 0 159 0 NOTCH2
SE_02_021300085 chr1:120083297-120145976 Sample_02_0213 Burkitts lymphoma of the left maxilla Raji_JQ1 85 3 1343 75 0 219 0 NOTCH2
SE_02_011100024 chr1:120083601-120154589 Sample_02_0111 Ovaries IOE4 24 8 1514 89 0 218 0 NOTCH2
SE_02_023400473 chr1:120083956-120154589 Sample_02_0234 Tonsil Th17 473 11 1504 89 0 212 0 NOTCH2
SE_02_099900313 chr1:120085744-120144018 Sample_02_0999 Lymphoma OCI-LY1_966 313 55 1254 72 0 199 0 SEC22B,NOTCH2
SE_02_021900250 chr1:120086461-120090872 Sample_02_0219 Mammary gland MDA-MB-231 250 3 98 7 0 15 0 NOTCH2
SE_02_152100338 chr1:120086850-120145847 Sample_02_1521 Skin A375 DMSO 338 10 1258 70 0 206 0 SEC22B,NOTCH2
SE_02_047500854 chr1:120088053-120117936 Sample_02_0475 Induced hepatocyte-like cells hepatocyte-like cells 854 10 699 37 0 133 0 NOTCH2
SE_02_156800837 chr1:120088222-120158527 Sample_02_1568 Heart Cardiac progenitor cells 837 13 1411 84 0 203 0 SEC22B,NOTCH2
SE_02_012200381 chr1:120089438-120133743 Sample_02_0122 Haematopoietic and lymphoid tissue TOLEDO 381 6 937 44 0 162 0 NOTCH2
SE_02_021001131 chr1:120089464-120094296 Sample_02_0210 Lung MRC-5_N_1DPT 1131 2 97 6 0 22 0 NOTCH2
SE_02_045500364 chr1:120090417-120144961 Sample_02_0455 Th17 lymphocytes Th17-IL-10+ Day 5 364 17 1162 66 0 190 0 SEC22B,NOTCH2
SE_00_000500344 chr1:120091395-120125375 Sample_00_0005 Blood B-cell 344 6 746 37 0 132 0 NOTCH2
SE_02_025600173 chr1:120091397-120147567 Sample_02_0256 Peripheral blood MV411 173 7 1186 66 0 193 0 NOTCH2
SE_02_008600312 chr1:120091523-120146531 Sample_02_0086 Pancreas CAPAN1 312 4 1165 65 0 192 0 NOTCH2
SE_02_054800347 chr1:120091596-120162949 Sample_02_0548 Blood THP-1_24h with EtOH 347 16 1329 82 0 194 0 SEC22B,NOTCH2
SE_01_005300143 chr1:120091859-120143878 Sample_01_0053 Haematopoietic and lymphoid tissue OCI-LY1 143 8 1111 60 0 183 0 NOTCH2
SE_02_099800447 chr1:120093077-120142899 Sample_02_0998 Lymphoma OCI-LY1_DMSO 447 45 1051 57 0 166 0 SEC22B,NOTCH2
SE_02_045600575 chr1:120098577-120145784 Sample_02_0456 Th17 lymphocytes Th17-IL-10- Day 0 575 14 994 57 0 169 0 SEC22B,NOTCH2
SE_02_038600068 chr1:120099195-120111191 Sample_02_0386 Lymph node CD19+_B_cells_FL1-2 68 4 240 12 0 66 0 NOTCH2
SE_02_034500281 chr1:120100095-120143293 Sample_02_0345 Blood AML8 281 9 887 49 0 154 0 NOTCH2
SE_02_034600036 chr1:120100211-120145499 Sample_02_0346 Blood AML10 36 8 939 52 0 163 0 NOTCH2
SE_02_057600239 chr1:120101515-120186605 Sample_02_0576 Blood HEL_sgLKB1e2 239 25 1137 104 0 178 99 SEC22B,NOTCH2
SE_02_010100167 chr1:120102295-120154589 Sample_02_0101 Peripheral blood Macrophages_GM-CSF_72h_IFN-y 167 5 1084 64 0 153 0 NOTCH2
SE_02_023200346 chr1:120102682-120154589 Sample_02_0232 Tonsil ILC3 346 8 1075 63 0 153 0 NOTCH2
SE_02_017700445 chr1:120104949-120145984 Sample_02_0177 Urinary bladder J82 445 5 853 48 0 151 0 NOTCH2
SE_02_015000801 chr1:120105505-120118122 Sample_02_0150 Mammary gland MDA-MB-231_GATA3 801 2 298 14 0 82 0 NOTCH2
SE_02_099000640 chr1:120105879-120145708 Sample_02_0990 Breast cancer brain metastatic variant MDA-MB-231 BrM2 640 9 831 46 0 151 0 SEC22B,NOTCH2
SE_02_149400227 chr1:120105939-120159440 Sample_02_1494 Other monocyte-derived dendritic cells_0h 227 16 1007 63 0 153 0 SEC22B,NOTCH2
SE_02_038100359 chr1:120107440-120146048 Sample_02_0381 Heart purified cardiomyocyte WT 359 4 808 44 0 147 0 NOTCH2
SE_02_039000011 chr1:120107815-120118146 Sample_02_0390 Peripheral blood CD19+_B_cells 11 8 260 11 0 78 0 NOTCH2
SE_02_017100834 chr1:120108782-120148248 Sample_02_0171 Lung IMR-90_proliferating 834 5 838 46 0 139 0 NOTCH2
SE_02_017200387 chr1:120109032-120154589 Sample_02_0172 Lung IMR-90_quiescent 387 6 963 58 0 139 0 NOTCH2
SE_02_143700154 chr1:120109269-120197800 Sample_02_1437 Liver LSEC-TNF 154 27 990 101 0 162 99 SEC22B,NOTCH2
SE_02_010700031 chr1:120109318-120154589 Sample_02_0107 Endometrium EEC16 31 4 952 58 0 137 0 NOTCH2
SE_02_028200201 chr1:120109382-120145870 Sample_02_0282 Lung IMR-90 201 4 774 43 0 134 0 NOTCH2
SE_02_011000070 chr1:120109507-120154589 Sample_02_0110 Ovaries IOE11 70 4 947 58 0 136 0 NOTCH2
SE_02_011600753 chr1:120109562-120146170 Sample_02_0116 Mammary gland MDA-MB-231_untreat 753 6 772 44 0 134 0 NOTCH2
SE_02_020900238 chr1:120109613-120154589 Sample_02_0209 Lung MRC-5_MRC5_1DPT 238 8 941 57 0 136 0 NOTCH2
SE_02_017500300 chr1:120109710-120153475 Sample_02_0175 Lung IMR-90_Etoposide 300 9 921 55 0 135 0 NOTCH2
SE_02_021000016 chr1:120109786-120154589 Sample_02_0210 Lung MRC-5_N_1DPT 16 10 937 57 0 136 0 NOTCH2
SE_02_143800256 chr1:120109813-120197624 Sample_02_1438 Liver LSEC 256 18 970 100 0 161 99 SEC22B,NOTCH2
SE_02_027400363 chr1:120109825-120146280 Sample_02_0274 Endometriosis hTERT_KD 363 7 764 43 0 134 0 NOTCH2
SE_02_143600233 chr1:120109868-120197597 Sample_02_1436 Liver LSEC-Ctrl 233 25 968 100 0 161 99 SEC22B,NOTCH2
SE_02_049900237 chr1:120109878-120182434 Sample_02_0499 Fetal lung IMR90 IR Senescence 237 21 968 95 0 161 99 SEC22B,NOTCH2
SE_02_088000023 chr1:120110022-120208412 Sample_02_0880 Ovary SVOG3e cells_noDox_transduced_V5-FOXL2_WT 23 17 966 103 0 153 99 SEC22B,NOTCH2
SE_02_087800039 chr1:120110022-120208431 Sample_02_0878 Ovary SVOG3e cells_noDox_control 39 15 966 103 0 153 99 SEC22B,NOTCH2
SE_02_007400030 chr1:120110029-120148048 Sample_02_0074 Other 90-8TL_PDJQ 30 7 795 44 0 126 0 NOTCH2
SE_02_008800027 chr1:120110144-120145984 Sample_02_0088 Umbilical cord umbilical-cord-derived-mesenchymal-stem-cells_SGA_cycle_0 27 7 752 42 0 103 0 NOTCH2
SE_02_088300068 chr1:120110198-120207570 Sample_02_0883 Ovary SVOG3e_cells_Dox_12h_transduced with V5-FOXL2 C134W 68 15 964 103 0 130 99 SEC22B,NOTCH2
SE_02_007300044 chr1:120110219-120147586 Sample_02_0073 Other 90-8TL_DMSO 44 5 778 44 0 104 0 NOTCH2
SE_02_015100261 chr1:120110414-120146267 Sample_02_0151 Mammary gland MDA-MB-231_TA1del 261 5 752 43 0 103 0 NOTCH2
SE_02_077000890 chr1:120110452-120147159 Sample_02_0770 Ovary OVCA429_shLuc 890 20 763 44 0 104 0 SEC22B,NOTCH2
SE_02_023000011 chr1:120110524-120145604 Sample_02_0230 Umbilical cord ID60 11 8 738 42 0 102 0 NOTCH2
SE_02_087900040 chr1:120110546-120208409 Sample_02_0879 Ovary SVOG3e cells_Dox_12h_control 40 18 954 103 0 129 99 SEC22B,NOTCH2
SE_02_011300465 chr1:120110559-120124641 Sample_02_0113 Connective tissue HT1080_DOX5d 465 3 312 15 0 39 0 NOTCH2
SE_02_022900014 chr1:120110722-120145528 Sample_02_0229 Umbilical cord ID01 14 10 734 42 0 102 0 NOTCH2
SE_02_047400268 chr1:120110731-120162872 Sample_02_0474 Fibroblast umbilical cord Fibroblast 268 16 917 61 0 104 0 SEC22B,NOTCH2
SE_01_005600031 chr1:120110789-120147628 Sample_01_0056 Bone osteoblast 31 5 769 44 0 103 0 NOTCH2
SE_02_088100234 chr1:120110863-120160117 Sample_02_0881 Ovary SVOG3e cells_Dox_12h_transduced_V5-FOXL2_WT 234 9 915 59 0 104 0 SEC22B,NOTCH2
SE_02_135600400 chr1:120110872-120159492 Sample_02_1356 Umbilical cord umbilical cord-derived mesenchymal stem cells_Young 400 8 915 59 0 104 0 SEC22B,NOTCH2
SE_02_026200178 chr1:120110891-120154589 Sample_02_0262 Osteoblastic hFOB_JQ1_differentiated 178 7 914 57 0 104 0 NOTCH2
SE_02_088200444 chr1:120110924-120160140 Sample_02_0882 Ovary SVOG3e_cells_noDox_transduced with V5-FOXL2 C134W 444 9 913 59 0 104 0 SEC22B,NOTCH2
SE_02_113701109 chr1:120110930-120159524 Sample_02_1137 Retinal Pigmented Epithelial RPE1-interphase 1109 12 913 59 0 104 0 SEC22B,NOTCH2
SE_02_106700242 chr1:120110988-120159434 Sample_02_1067 Bone SJSA-1 242 9 911 59 0 104 0 SEC22B,NOTCH2
SE_02_076300361 chr1:120111024-120207393 Sample_02_0763 Podocyte podocyte_DEX 361 15 943 103 0 129 99 SEC22B,NOTCH2
SE_02_009100022 chr1:120111055-120146143 Sample_02_0091 Umbilical cord umbilical-cord-derived-mesenchymal-stem-cells_Control_cycle_0 22 6 733 43 0 102 0 NOTCH2
SE_02_026300147 chr1:120111165-120154589 Sample_02_0263 Osteoblastic hFOB_undifferentiated 147 8 907 57 0 104 0 NOTCH2
SE_02_135500383 chr1:120111184-120160080 Sample_02_1355 Umbilical cord umbilical cord-derived mesenchymal stem cells_old 383 8 907 59 0 104 0 SEC22B,NOTCH2
SE_02_076700630 chr1:120111191-120145865 Sample_02_0767 Ovary OVCA429 630 19 730 42 0 102 0 SEC22B,NOTCH2
SE_02_053100405 chr1:120111244-120145742 Sample_02_0531 Mammary gland MDA-MB-231 405 10 729 42 0 102 0 SEC22B,NOTCH2
SE_02_063800388 chr1:120111433-120159988 Sample_02_0638 Fibroblast HGPS fibroblast_LMNA_AG11498 388 19 905 59 0 99 0 SEC22B,NOTCH2
SE_01_011501155 chr1:120111433-120165354 Sample_01_0115 Skeletal Muscle myotube originated from skeletal muscle myoblast 1155 9 905 63 0 99 0 SEC22B,NOTCH2
SE_02_009200130 chr1:120111464-120146049 Sample_02_0092 Umbilical cord umbilical-cord-derived-mesenchymal-stem-cells_Control_cycle_3 130 4 728 42 0 97 0 NOTCH2
SE_02_028000519 chr1:120111538-120154182 Sample_02_0280 Mammary gland SUM159_DMSO_24h 519 6 899 56 0 98 0 NOTCH2
SE_02_076900476 chr1:120111782-120159428 Sample_02_0769 Ovary HEYA8 476 26 898 59 0 99 0 SEC22B,NOTCH2
SE_02_058000272 chr1:120111860-120186506 Sample_02_0580 Blood HEL_sgSIK3e4 272 25 932 95 0 124 99 SEC22B,NOTCH2
SE_02_141800074 chr1:120111935-120198012 Sample_02_1418 Brain SF9427 74 14 930 100 0 124 99 SEC22B,NOTCH2
SE_02_057900897 chr1:120111978-120147182 Sample_02_0579 Blood HEL_sgNeg2 897 17 736 44 0 98 0 SEC22B,NOTCH2
SE_02_113300464 chr1:120111992-120159789 Sample_02_1133 Liver Hepatic stellate cells 464 10 894 59 0 99 0 SEC22B,NOTCH2
SE_02_137700671 chr1:120111996-120160020 Sample_02_1377 Pancreas Pancreatic_tumor_associated_fibroblasts_BF1_untreated 671 18 894 59 0 99 0 SEC22B,NOTCH2
SE_02_137901062 chr1:120112000-120145383 Sample_02_1379 Pancreas Pancreatic_tumor_associated_fibroblasts_PS1_untreated 1062 10 709 42 0 97 0 SEC22B,NOTCH2
SE_02_137800521 chr1:120112011-120159971 Sample_02_1378 Pancreas Pancreatic_tumor_associated_fibroblasts_CAF08_untreated 521 18 893 59 0 99 0 SEC22B,NOTCH2
SE_00_002500549 chr1:120112619-120146015 Sample_00_0025 Muscle of leg muscle-of-leg 549 6 695 41 0 93 0 NOTCH2
SE_02_040600522 chr1:120113043-120118194 Sample_02_0406 Mammary gland ZR-75-30_parental 522 2 145 9 0 23 0 NOTCH2
SE_01_001800093 chr1:120114328-120148014 Sample_01_0018 Submandibular Salivary Gland ACC112 93 6 688 41 0 83 0 NOTCH2
SE_02_024300104 chr1:120115177-120150969 Sample_02_0243 Foreskin foreskin_HFFs 104 4 743 51 0 83 0 NOTCH2
SE_02_026100206 chr1:120115276-120154589 Sample_02_0261 Osteoblastic hFOB_differentiated 206 8 792 53 0 84 0 NOTCH2
SE_02_033200436 chr1:120115278-120149170 Sample_02_0332 Haematopoietic and lymphoid tissue MOLM14_DMSO_9 436 2 678 44 0 83 0 NOTCH2
SE_02_142800757 chr1:120115345-120159972 Sample_02_1428 Shoulder fibroblast_316 757 10 792 55 0 84 0 SEC22B,NOTCH2
SE_01_008801130 chr1:120115432-120154589 Sample_01_0088 Tibial nerve tibial-nerve 1130 6 791 53 0 84 0 NOTCH2
SE_01_006600769 chr1:120115444-120146042 Sample_01_0066 Smooth muscle smooth-muscle-cell 769 3 614 38 0 82 0 NOTCH2
SE_02_142700396 chr1:120115446-120197927 Sample_02_1427 Shoulder fibroblast_343 396 19 826 96 0 109 99 SEC22B,NOTCH2
SE_02_033400373 chr1:120115486-120148617 Sample_02_0334 Haematopoietic and lymphoid tissue MOLM14_CA25_11 373 4 669 43 0 83 0 NOTCH2
SE_02_009300269 chr1:120115501-120146728 Sample_02_0093 Umbilical cord umbilical-cord-derived-mesenchymal-stem-cells_Control_cycle_6 269 3 627 40 0 82 0 NOTCH2
SE_02_041900203 chr1:120115553-120146035 Sample_02_0419 Pectoralis major muscle LHCN-M2_nodox 203 7 609 38 0 82 0 NOTCH2
SE_02_142500229 chr1:120115574-120198162 Sample_02_1425 Shoulder fibroblast_384 229 23 821 96 0 109 99 SEC22B,NOTCH2
SE_02_142600193 chr1:120115603-120197769 Sample_02_1426 Shoulder fibroblast_341 193 22 820 96 0 109 99 SEC22B,NOTCH2
SE_01_004200041 chr1:120115650-120137277 Sample_01_0042 Haematopoietic and lymphoid tissue KMS-11 41 3 423 17 0 55 0 NOTCH2
SE_02_157100624 chr1:120115673-120160150 Sample_02_1571 Fibroblast Fibroblast cells 624 9 781 55 0 84 0 SEC22B,NOTCH2
SE_02_157300177 chr1:120115790-120197310 Sample_02_1573 Endothelial Undifferentiated Pleomorphic Sarcoma 177 28 813 96 0 109 99 SEC22B,NOTCH2
SE_02_086700905 chr1:120115805-120159425 Sample_02_0867 Bone marrow Bone marrow derived hMSC_d0 905 21 778 55 0 84 0 SEC22B,NOTCH2
SE_02_122000344 chr1:120115832-120145223 Sample_02_1220 Bone marrow JJN3 344 15 590 38 0 82 0 SEC22B,NOTCH2
SE_02_155200160 chr1:120115870-120198339 Sample_02_1552 HMSCs hMSC ATCC SCRC-4000 160 20 810 96 0 109 99 SEC22B,NOTCH2
SE_02_014400177 chr1:120115875-120147215 Sample_02_0144 Peripheral blood MV411_DMSO 177 3 617 40 0 83 0 NOTCH2
SE_02_131100127 chr1:120115911-120190590 Sample_02_1311 Bone marrow HDMSCs 127 12 810 92 0 109 99 SEC22B,NOTCH2
SE_02_131000160 chr1:120116077-120197687 Sample_02_1310 Bone marrow ASMSCs 160 15 805 96 0 109 99 SEC22B,NOTCH2
SE_01_005400334 chr1:120116163-120125457 Sample_01_0054 Haematopoietic and lymphoid tissue OCI-LY3 334 1 180 11 0 22 0 NOTCH2
SE_02_026400924 chr1:120116455-120145625 Sample_02_0264 Skeletal muscle 7250-empty 924 3 584 38 0 82 0 NOTCH2
SE_02_034200497 chr1:120116474-120146035 Sample_02_0342 Liver HSPCs_F0 497 5 585 38 0 82 0 NOTCH2
SE_02_086800127 chr1:120116553-120197805 Sample_02_0868 Bone marrow Bone marrow derived hMSC_d10 127 36 795 96 0 109 99 SEC22B,NOTCH2
SE_02_033700609 chr1:120116818-120146123 Sample_02_0337 Haematopoietic and lymphoid tissue MV411_untreat 609 5 583 37 0 81 0 NOTCH2
SE_02_145800224 chr1:120116853-120159264 Sample_02_1458 Pancreas THP1+PANC1_shNC 224 12 756 53 0 83 0 SEC22B,NOTCH2
SE_02_034300238 chr1:120116876-120146028 Sample_02_0343 Bone marrow HSPC_A0 238 5 577 35 0 81 0 NOTCH2
SE_02_046600426 chr1:120116900-120198001 Sample_02_0466 Adipose visceral adipocytes 426 38 783 93 0 108 99 SEC22B,NOTCH2
SE_01_002900579 chr1:120117046-120145533 Sample_01_0029 Lung fibroblast-of-lung 579 4 562 35 0 81 0 NOTCH2
SE_02_149201401 chr1:120117259-120145910 Sample_02_1492 Peripheral blood CD34+ derived peripheral blood-derived mast cells 1401 8 556 34 0 81 0 SEC22B,NOTCH2
SE_02_037600341 chr1:120118890-120143217 Sample_02_0376 Skeletal muscle RMS237 341 3 465 28 0 60 0 NOTCH2
Genomic distribution of SEs associated with NOTCH2
Genome Browser

The strength of the tissue affected by the gene

Expression of NOTCH2

Cell line (ENCODE) Primary cell (ENCODE)Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)