SEdb 2.0
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Gene overview

Strategies/Algorithm: proximal Ensembl ID: ENSG00000136044
Gene: APPL2 Gene type: protein_coding
Strand: - External links:
Genomic region: chr12:105173297-105236203 Genome Browser:

Super-enhancer search result of gene-based

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SE ID SE Region Sample ID Tissue type Biosample name SE rank Element Common SNP eQTL Risk SNP TFBS CRISPR Cas9 Gene
SE_02_026400212 chr12:105252042-105259777 Sample_02_0264 Skeletal muscle 7250-empty 212 1 227 24 0 5 0 APPL2
SE_02_026100533 chr12:105252183-105269973 Sample_02_0261 Osteoblastic hFOB_differentiated 533 3 505 68 0 8 0 APPL2
SE_02_026500237 chr12:105252200-105293098 Sample_02_0265 Skeletal muscle 7250-PAX3-FOXO1 237 5 1156 197 1 40 0 APPL2,C12ORF75
SE_02_045100880 chr12:105252320-105270433 Sample_02_0451 Skin in vitro transformedskin fibroblasts_tumourigenic 880 4 512 69 0 8 0 APPL2
SE_02_041900790 chr12:105252349-105269744 Sample_02_0419 Pectoralis major muscle LHCN-M2_nodox 790 2 496 66 0 8 0 APPL2
SE_02_060600289 chr12:105252387-105271865 Sample_02_0606 Skin Skin Fibroblast_Nutlin3A 289 4 547 73 0 13 0 APPL2
SE_02_026200577 chr12:105252399-105259410 Sample_02_0262 Osteoblastic hFOB_JQ1_differentiated 577 1 209 20 0 5 0 APPL2
SE_02_060500266 chr12:105252408-105271930 Sample_02_0605 Skin Skin Fibroblast_DMSO 266 5 549 73 0 13 0 APPL2
SE_02_156600735 chr12:105252412-105270886 Sample_02_1566 Dermal Dermal fibroblast 735 4 520 70 0 8 0 APPL2,C12orf75
SE_02_088300861 chr12:105252456-105278731 Sample_02_0883 Ovary SVOG3e_cells_Dox_12h_transduced with V5-FOXL2 C134W 861 3 731 95 1 18 0 APPL2,KCCAT198
SE_02_026300699 chr12:105252469-105259890 Sample_02_0263 Osteoblastic hFOB_undifferentiated 699 1 215 21 0 5 0 APPL2
SE_02_143601074 chr12:105252571-105259252 Sample_02_1436 Liver LSEC-Ctrl 1074 1 197 18 0 4 0 APPL2
SE_02_157100199 chr12:105252640-105262980 Sample_02_1571 Fibroblast Fibroblast cells 199 2 289 25 0 8 0 APPL2
SE_02_087800806 chr12:105252682-105259464 Sample_02_0878 Ovary SVOG3e cells_noDox_control 806 1 202 17 0 5 0 APPL2
SE_02_020901340 chr12:105252685-105268827 Sample_02_0209 Lung MRC-5_MRC5_1DPT 1340 2 453 58 0 8 0 APPL2
SE_02_005400268 chr12:105252697-105259667 Sample_02_0054 Lung IMR-90_DMSO_1 268 1 205 18 0 5 0 APPL2
SE_02_063600464 chr12:105252698-105271864 Sample_02_0636 Skin BJ5ta 464 5 536 70 0 13 0 APPL2
SE_02_087900801 chr12:105252743-105259514 Sample_02_0879 Ovary SVOG3e cells_Dox_12h_control 801 1 203 18 0 5 0 APPL2
SE_02_050000665 chr12:105252787-105289919 Sample_02_0500 Fetal lung IMR90_#2 665 9 1038 172 1 36 0 APPL2,KCCAT198,C12ORF75
SE_02_005500276 chr12:105252801-105259609 Sample_02_0055 Lung IMR-90_Nutlin-3a 276 1 203 18 0 5 0 APPL2
SE_02_143801022 chr12:105252802-105259512 Sample_02_1438 Liver LSEC 1022 1 202 18 0 5 0 APPL2
SE_02_113300508 chr12:105252820-105259034 Sample_02_1133 Liver Hepatic stellate cells 508 1 182 17 0 2 0 APPL2
SE_02_063700332 chr12:105252825-105271257 Sample_02_0637 Fibroblast fibroblast_WT_GM07492 332 4 516 68 0 8 0 APPL2
SE_02_061001034 chr12:105252832-105259552 Sample_02_0610 Liposarcoma MLS 1765-92 1034 1 199 18 0 5 0 APPL2
SE_02_088200706 chr12:105252901-105270917 Sample_02_0882 Ovary SVOG3e_cells_noDox_transduced with V5-FOXL2 C134W 706 2 501 67 0 8 0 APPL2
SE_02_049901656 chr12:105252905-105259295 Sample_02_0499 Fetal lung IMR90 IR Senescence 1656 3 186 17 0 5 0 APPL2
SE_02_072700251 chr12:105252938-105259354 Sample_02_0727 Fetal lung IMR90_Etoposide 251 1 185 16 0 5 0 APPL2
SE_02_088101069 chr12:105252958-105260111 Sample_02_0881 Ovary SVOG3e cells_Dox_12h_transduced_V5-FOXL2_WT 1069 2 205 19 0 5 0 APPL2
SE_02_088601042 chr12:105252964-105289863 Sample_02_0886 Skin foreskin_ p63KLF4 1042 9 1028 171 1 36 0 APPL2,KCCAT198,C12ORF75
SE_02_088001201 chr12:105253037-105259268 Sample_02_0880 Ovary SVOG3e cells_noDox_transduced_V5-FOXL2_WT 1201 1 181 15 0 4 0 APPL2
SE_02_153700661 chr12:105253207-105258240 Sample_02_1537 Mammary gland MDA-MB-231_ER?_L540Q_45min 661 1 148 14 0 1 0 APPL2
SE_02_135500566 chr12:105253233-105259011 Sample_02_1355 Umbilical cord umbilical cord-derived mesenchymal stem cells_old 566 1 166 15 0 2 0 APPL2
SE_02_045201024 chr12:105253242-105263106 Sample_02_0452 Skin hTERT immortalised human skin fibroblasts_Non-tumourigenic 1024 2 272 23 0 8 0 APPL2
SE_02_086900530 chr12:105253300-105290092 Sample_02_0869 Fibroblast VH10_NO_UV 530 12 1025 171 1 36 0 APPL2,KCCAT198,C12ORF75
SE_02_127200787 chr12:105253391-105258537 Sample_02_1272 Leiomyosarcoma SK-LMS-1_HDAC4KO 787 8 149 14 0 1 0 APPL2
SE_02_158300810 chr12:105253399-105259441 Sample_02_1583 Fetal lung IMR90_empty_GM 810 6 175 15 0 5 0 APPL2
SE_02_153600495 chr12:105253401-105258104 Sample_02_1536 Mammary gland MDA-MB-231_ER?_L540Q_0min 495 2 140 14 0 1 0 APPL2
SE_02_063801081 chr12:105253497-105269857 Sample_02_0638 Fibroblast HGPS fibroblast_LMNA_AG11498 1081 4 458 60 0 8 0 APPL2
SE_02_108400107 chr12:105259170-105278815 Sample_02_1084 Blood KBM7-derived near haploid cells 107 8 533 77 1 14 0 APPL2,KCCAT198
SE_02_077600201 chr12:105276628-105334621 Sample_02_0776 Pancreas EndoC-BH1 201 13 1703 269 2 75 280 C12ORF75,KCCAT198,APPL2
SE_02_024000170 chr12:105279914-105358366 Sample_02_0240 Colon V429_2 170 26 2219 298 3 97 302 C12ORF75,APPL2
SE_02_002100167 chr12:105280210-105336228 Sample_02_0021 Colon V429 167 6 1638 255 2 76 280 C12ORF75,APPL2
SE_02_127901530 chr12:105280782-105341643 Sample_02_1279 Bone Mesenchymal stem cells 1530 12 1782 269 2 80 280 C12ORF75,KCCAT198,APPL2
Genomic distribution of SEs associated with APPL2
Genome Browser

The strength of the tissue affected by the gene

Expression of APPL2

Cell line (ENCODE) Primary cell (ENCODE)Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)