SEdb 2.0
  1. Search
  2. Super-enhancer search result of gene-based

Gene overview

Strategies/Algorithm: closest_active Ensembl ID: ENSG00000141458
Gene: NPC1 Gene type: protein_coding
Strand: - External links:
Genomic region: chr18:23506184-23586506 Genome Browser:

Super-enhancer search result of gene-based

GREAT Download bed
SE ID SE Region Sample ID Tissue type Biosample name SE rank Element Common SNP eQTL Risk SNP TFBS CRISPR Cas9 Gene
SE_02_048100175 chr18:23505180-23597953 Sample_02_0481 Mammary gland MDA-MB231 175 34 2652 190 6 177 2556 NPC1,C18ORF8
SE_02_151300307 chr18:23521604-23586270 Sample_02_1513 Lung Transitional AT2->1 cells 307 14 1872 122 6 149 2052 NPC1,C18ORF8
SE_02_117300754 chr18:23528490-23587072 Sample_02_1173 Brain GBM01 754 17 1690 110 5 140 1954 NPC1,C18ORF8
SE_02_119600825 chr18:23528545-23587433 Sample_02_1196 Brain GBM32 825 20 1700 113 5 140 1943 NPC1,C18ORF8
SE_02_153300064 chr18:23545427-23586198 Sample_02_1533 Lung purified primary alveolar epithelial type 2 cells 64 11 1137 71 2 67 614 NPC1,C18ORF8
SE_02_147000908 chr18:23545448-23594685 Sample_02_1470 Umbilical Vein H441 908 14 1369 104 2 70 779 NPC1,C18ORF8
SE_02_103501009 chr18:23545578-23594658 Sample_02_1035 Mammary gland HCC70_Vehicle 1009 20 1366 104 2 70 779 NPC1,C18ORF8
SE_02_151000599 chr18:23545867-23594672 Sample_02_1510 Lung H3122_LR_Pano 599 17 1360 104 2 70 779 NPC1,C18ORF8
SE_02_053000753 chr18:23546063-23593995 Sample_02_0530 Mammary gland MCF10A 753 16 1341 103 2 70 779 NPC1,C18ORF8
SE_02_151200071 chr18:23546327-23586213 Sample_02_1512 Lung Purified AT2 cells 71 14 1114 69 2 67 618 NPC1,C18ORF8
SE_02_121300897 chr18:23553901-23587141 Sample_02_1213 Brain GBM31 897 11 940 56 2 60 680 NPC1
SE_02_120501119 chr18:23559702-23587063 Sample_02_1205 Brain NB3 1119 7 758 48 2 44 435 NPC1
SE_02_120301038 chr18:23559980-23587083 Sample_02_1203 Brain NB1 1038 9 745 48 2 44 435 NPC1
SE_02_017300495 chr18:23562299-23595698 Sample_02_0173 Lung IMR-90_senescent 495 8 910 82 1 31 293 NPC1
SE_02_035900753 chr18:23563044-23594494 Sample_02_0359 Colon Colo741 753 4 854 72 1 31 293 NPC1
SE_02_010100759 chr18:23563087-23597821 Sample_02_0101 Peripheral blood Macrophages_GM-CSF_72h_IFN-y 759 5 943 82 1 31 293 NPC1
SE_02_015800254 chr18:23563163-23595117 Sample_02_0158 Brain U87_EGFRvIII_erlotinib 254 8 863 73 1 31 293 NPC1
SE_02_126300340 chr18:23563203-23596482 Sample_02_1263 Bone Im-GCT-4072_G34W unedited 340 14 903 79 1 31 293 NPC1
SE_02_017501005 chr18:23563240-23594702 Sample_02_0175 Lung IMR-90_Etoposide 1005 8 853 71 1 31 293 NPC1
SE_02_042800427 chr18:23563247-23595989 Sample_02_0428 Kidney 12364284_VHL- 427 7 887 77 1 31 293 NPC1
SE_02_158400029 chr18:23563284-23596730 Sample_02_1584 Brain U87 GBM_Mock 29 7 912 79 1 31 293 NPC1
SE_02_154800467 chr18:23563289-23597180 Sample_02_1548 Gastrointestinal Stromal GIST-226 467 11 922 80 1 31 293 NPC1
SE_02_155100529 chr18:23563321-23586981 Sample_02_1551 Gastrointestinal Stromal MaMel 529 8 644 40 1 31 293 NPC1
SE_02_132100441 chr18:23563371-23595551 Sample_02_1321 Connective Tissue HT1080_FUS-DDIT3 441 11 868 76 1 31 293 NPC1
SE_02_131100831 chr18:23563413-23597181 Sample_02_1311 Bone marrow HDMSCs 831 6 918 80 1 31 293 NPC1
SE_02_093001125 chr18:23563434-23596821 Sample_02_0930 Mid-gestation placenta trophoblast__SynT 1125 19 910 80 1 31 293 NPC1
SE_02_116801109 chr18:23563470-23593620 Sample_02_1168 Biliary H69_TGF Vehicle_2 1109 7 821 69 1 31 293 NPC1
SE_02_157900704 chr18:23563485-23595712 Sample_02_1579 Renal 786-M1A 704 9 872 77 1 31 293 NPC1
SE_02_126500786 chr18:23563495-23594725 Sample_02_1265 Bone Im-GCT-4072_G34W-repair_WT_D6 786 8 847 71 1 31 293 NPC1
SE_02_125900059 chr18:23563515-23595487 Sample_02_1259 Bone Im-GCT-3504_G34W-repair_WT_4C7 59 9 863 76 1 31 293 NPC1
SE_02_141800192 chr18:23564034-23595568 Sample_02_1418 Brain SF9427 192 3 847 73 1 31 293 NPC1
SE_02_076201822 chr18:23564114-23597010 Sample_02_0762 Podocyte podocyte_CTL 1822 9 895 77 1 31 293 NPC1
SE_02_158000797 chr18:23564304-23595634 Sample_02_1580 Renal 786-O 797 12 843 74 1 31 293 NPC1
SE_02_001300386 chr18:23565672-23595490 Sample_02_0013 Kidney 786-O_HIF2A 386 10 805 72 1 31 293 NPC1
SE_02_040200494 chr18:23565796-23595337 Sample_02_0402 Mammary gland SUM159PT-ZR-75-1 494 6 795 70 1 31 293 NPC1
SE_02_126600994 chr18:23571027-23594371 Sample_02_1266 Bone Im-GCT-4072_G34W-repair_WT_E3 994 9 636 59 1 21 262 NPC1
SE_02_138800244 chr18:23571225-23597774 Sample_02_1388 Peripheral blood JB6_ALK+ 244 16 723 69 1 20 262 NPC1
SE_02_122700512 chr18:23572053-23587682 Sample_02_1227 Bone marrow U266 512 7 424 30 1 20 257 NPC1
SE_02_080800299 chr18:23572063-23635155 Sample_02_0808 Ovary RMG1_ARID1A KO 299 35 1625 116 1 85 687 ANKRD29,NPC1
SE_02_093700391 chr18:23572066-23587678 Sample_02_0937 Retinal Pigmented Epithelial RPE190_Con 391 5 424 30 1 20 253 NPC1
SE_02_154900410 chr18:23572392-23595692 Sample_02_1549 Gastrointestinal Stromal GIST-430B 410 11 635 62 1 17 233 NPC1
SE_02_092901028 chr18:23572514-23586912 Sample_02_0929 Mid-gestation placenta trophoblast__CytT 1028 7 398 23 1 17 233 NPC1
SE_02_126401031 chr18:23572571-23594622 Sample_02_1264 Bone Im-GCT-4072_G34W KO 1031 7 605 55 1 17 233 NPC1
SE_01_010400915 chr18:23572608-23587470 Sample_01_0104 Lung upper lobe of left lung 915 8 413 27 1 17 233 NPC1
SE_02_157301312 chr18:23573289-23596920 Sample_02_1573 Endothelial Undifferentiated Pleomorphic Sarcoma 1312 8 657 60 1 17 228 NPC1
SE_02_116701003 chr18:23573320-23594243 Sample_02_1167 Biliary H69_TGF Vehicle_1 1003 11 579 51 1 17 225 NPC1
SE_02_126900790 chr18:23573328-23590058 Sample_02_1269 Bone Im-GCT-4072_G34W-repair_WT_A4 790 3 456 33 1 17 224 NPC1
SE_02_139000611 chr18:23573437-23595382 Sample_02_1390 Peripheral blood SU-DHL-1_ALK+ 611 5 596 54 1 17 213 NPC1
SE_02_064501920 chr18:23573563-23586880 Sample_02_0645 Tracheobronchial epithelial HTBE_H1N1_18h 1920 2 374 19 1 14 196 NPC1
SE_02_086701485 chr18:23573613-23596637 Sample_02_0867 Bone marrow Bone marrow derived hMSC_d0 1485 13 639 59 1 14 191 NPC1
SE_02_126000273 chr18:23573646-23595238 Sample_02_1260 Bone Im-GCT-3504_G34W-repair_4F5 273 7 591 54 1 14 189 NPC1
SE_02_001000807 chr18:23573695-23595743 Sample_02_0010 Kidney A-498_emptyvector 807 5 603 57 1 14 186 NPC1
SE_02_011200794 chr18:23573707-23595515 Sample_02_0112 Connective tissue HT1080_untreated 794 5 595 56 1 14 186 NPC1
SE_02_076900851 chr18:23573724-23595623 Sample_02_0769 Ovary HEYA8 851 13 600 57 1 14 186 NPC1
SE_02_135300555 chr18:23573791-23595019 Sample_02_1353 Mammary gland MDA-MB-231-Erbeta_TNFa 555 7 581 52 1 14 183 NPC1
SE_02_071900603 chr18:23573798-23593838 Sample_02_0719 Pancreas SUIT2_TP63dN_DOX 603 4 556 50 1 14 183 NPC1
SE_02_071600486 chr18:23573802-23586928 Sample_02_0716 Pancreas SUIT2_GFP 486 3 366 19 1 14 183 NPC1
SE_02_145201101 chr18:23573808-23594699 Sample_02_1452 Arter pulmonary arterial smooth muscle cells_PAH2_sictrl 1101 7 575 51 1 14 183 NPC1
SE_02_127500403 chr18:23573905-23596060 Sample_02_1275 Prostate PC3_Vorinostat 403 16 607 57 1 14 183 NPC1
SE_02_071100977 chr18:23573923-23586873 Sample_02_0711 Pancreas hN35_organoid 977 4 360 19 1 14 183 NPC1
SE_02_042900202 chr18:23573981-23595988 Sample_02_0429 Kidney 12364284_VHL+ 202 6 602 57 1 14 183 NPC1
SE_02_071400402 chr18:23573988-23586964 Sample_02_0714 Pancreas SUIT2_MTV 402 2 361 20 1 14 183 NPC1
SE_02_136500573 chr18:23573990-23587688 Sample_02_1365 Pancreas AsPC1-untreated 573 2 377 25 1 14 183 NPC1
SE_02_026800652 chr18:23574232-23595779 Sample_02_0268 Kidney A-498 652 4 590 56 1 12 183 NPC1
SE_02_126100255 chr18:23574251-23595216 Sample_02_1261 Bone Im-GCT-3504_G34W_unedited 255 7 571 51 1 12 183 NPC1
SE_02_043000380 chr18:23574273-23595709 Sample_02_0430 Kidney 12364284 380 5 587 56 1 12 183 NPC1
SE_02_132000564 chr18:23574338-23595220 Sample_02_1320 Connective Tissue HT1080_EWS-FLI1 564 5 570 51 1 12 183 NPC1
SE_02_122800467 chr18:23574372-23597174 Sample_02_1228 Mammary gland MDA-MB-231_2 467 10 629 59 1 12 183 NPC1
SE_02_145400514 chr18:23574456-23599801 Sample_02_1454 Arter pulmonary arterial smooth muscle cells_PAH1_sialdh1a3 514 8 693 65 1 20 183 ANKRD29,NPC1
SE_02_111000817 chr18:23574530-23590162 Sample_02_1110 Other HGrC1 817 6 425 32 1 12 183 NPC1
SE_02_084600471 chr18:23579102-23597013 Sample_02_0846 Mammary gland MDA-MB-231_untreat 471 9 457 54 1 10 183 NPC1
SE_02_026700401 chr18:23580759-23596704 Sample_02_0267 Kidney 786-O 401 4 418 51 0 10 183 NPC1
SE_02_001200289 chr18:23580767-23595702 Sample_02_0012 Kidney 786-O_non-targeting 289 6 383 49 0 10 183 NPC1
SE_02_001100963 chr18:23580865-23595745 Sample_02_0011 Kidney A-498_wtVHL 963 6 383 49 0 9 183 NPC1
SE_02_000900255 chr18:23580893-23596377 Sample_02_0009 Kidney 786-O_wtVHL 255 3 401 50 0 9 183 NPC1
SE_02_026900190 chr18:23580937-23596378 Sample_02_0269 Kidney HK-2 190 3 399 50 0 9 183 NPC1
SE_02_126700290 chr18:23581202-23596730 Sample_02_1267 Bone Im-GCT-4072_G34W 290 7 411 50 0 9 183 NPC1
SE_02_099200442 chr18:23581536-23596987 Sample_02_0992 Mammary gland MDA-MB-231_Par 442 5 410 51 0 8 183 NPC1
SE_02_126800279 chr18:23582394-23594736 Sample_02_1268 Bone Im-GCT-4072_G34W unedited_U3 279 3 318 38 0 8 183 NPC1
SE_02_099100466 chr18:23582411-23596923 Sample_02_0991 Breast cancer cell line lung metastatic variant MDA-MB-231 LM2 466 6 382 47 0 8 183 NPC1
SE_02_071800098 chr18:23583547-23586991 Sample_02_0718 Pancreas PATU8988S_GFP_DOX 98 1 81 7 0 8 183 NPC1
SE_02_011600615 chr18:23583748-23595831 Sample_02_0116 Mammary gland MDA-MB-231_untreat 615 1 313 44 0 5 183 NPC1
SE_02_071500478 chr18:23583831-23594927 Sample_02_0715 Pancreas SUIT2_TP63dN 478 3 287 39 0 5 183 NPC1
SE_02_070300065 chr18:23583832-23588201 Sample_02_0703 Pancreas PATU8988S WT 65 1 102 13 0 5 183 NPC1
SE_02_072200057 chr18:23583972-23586978 Sample_02_0722 Pancreas PATU8988S_TP63dN_DOX 57 1 72 7 0 5 183 NPC1
SE_02_137100029 chr18:23584138-23587689 Sample_02_1371 Pancreas Patu899S-untreated 29 2 85 12 0 5 183 NPC1
SE_02_099000607 chr18:23588462-23596599 Sample_02_0990 Breast cancer brain metastatic variant MDA-MB-231 BrM2 607 5 233 32 0 0 0 NPC1
SE_02_151400658 chr18:23609080-23636488 Sample_02_1514 Lung Differentiated AT1-like cells 658 6 680 32 0 57 311 ANKRD29,NPC1,LAMA3
SE_00_000301315 chr18:23609097-23636547 Sample_00_0003 Adrenal gland adrenal-gland_97d 1315 6 680 32 0 57 311 ANKRD29,NPC1
SE_01_004200365 chr18:23614021-23619245 Sample_01_0042 Haematopoietic and lymphoid tissue KMS-11 365 2 121 5 0 3 39 ANKRD29,NPC1
SE_02_051100732 chr18:23626016-23630699 Sample_02_0511 Prostate LNCaP95_shARv7_ETOH 732 3 124 7 0 11 66 ANKRD29,NPC1
Genomic distribution of SEs associated with NPC1
Genome Browser

The strength of the tissue affected by the gene

Expression of NPC1

Cell line (ENCODE) Primary cell (ENCODE)Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)