| Gene name: | ATF6 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | NHDF |
| Experiment: | Knockdown//SA-β-gal activity assay |
| Description: | Only ATF6α knockdown significantly reduced the number of SA-β-Gal positive-cells upon DTT treatment. |
| Regulatory pathway: | COX-2-PGE2 |
| R-AG-Pathway: | Activation |
| Official symbol(s): | COX2 |
| Pathway experiment: | ELISA//qRT-PCR//Knockdown//Western blot |
| Pathway description: | ELISA assays showed that the increase in PGE2 synthesis and secretion induced by DTT was totally abolished upon ATF6 knocked-down cells .Knockdown of ATF6 and IRE1 but not PERK, reduced COX2 mRNA and protein levels at senescence, as well as the production and secretion of PGE2. |
Annotation:
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