T(co)F Overview
T(co)F: Ezh2
Species: Mus musculus
Knock-Method: shRNA
T(co)F Class: Others
T(co)F Superclass: TcoF-DB_TF
Biosample Name: SVZ derived neural stem cells
Tissue Type: Brain
Biosample Type: Stem cell
# of Control: 2
# of Treat: 9
Data Source: GEO
Profile ID: GSE63853
Platform: GPL13112
Pubmed ID: 25600873

Ezh2- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of Ezh2
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of Ezh2
Upstream Pathway Annotation of Ezh2
T(co)F Pathway Name Source Gene Number
Ezh2 PRC2_PATHWAY BIOCARTA 10
Ezh2 EPIGENETIC_REGULATION_OF_GENE_EXPRESSION REACTOME 112
Ezh2 PRC2_METHYLATES_HISTONES_AND_DNA REACTOME 81
Ezh2 GENERIC_TRANSCRIPTION_PATHWAY REACTOME 842
Ezh2 OXIDATIVE_STRESS_INDUCED_SENESCENCE REACTOME 38
Ezh2 CELLULAR_SENESCENCE REACTOME 95
Ezh2 PKMTS_METHYLATE_HISTONE_LYSINES REACTOME 67
Ezh2 CHROMATIN_MODIFYING_ENZYMES REACTOME 205
Ezh2 PTEN_REGULATION REACTOME 113
Ezh2 GENE_EXPRESSION_TRANSCRIPTION REACTOME 1061
Ezh2 REGULATION_OF_PTEN_GENE_TRANSCRIPTION REACTOME 42
Ezh2 TRANSCRIPTIONAL_REGULATION_BY_E2F6 REACTOME 23
Ezh2 CELLULAR_RESPONSES_TO_STIMULI REACTOME 454
Ezh2 INTRACELLULAR_SIGNALING_BY_SECOND_MESSENGERS REACTOME 260
Ezh2 MECP2_AND_ASSOCIATED_RETT_SYNDROME WP 45
Ezh2 MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY WP 290
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of Ezh2
T(co)F Expression in Mouse Cell (Fantom5) T(co)F Expression in Mouse Tissue (Fantom5)