T(co)F Overview
T(co)F: Irf7
Species: Mus musculus
Knock-Method: knockout
T(co)F Class: Tryptophan cluster factors
T(co)F Superclass: Helix-turn-helix domains
Biosample Name: c-kit+ leukemic cells
Tissue Type: Bone_marrow
Biosample Type: Primary cell
# of Control: 6
# of Treat: 3
Data Source: GEO
Profile ID: GSE178560
Platform: GPL24247
Pubmed ID: 35256780

Irf7- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of Irf7
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of Irf7
Upstream Pathway Annotation of Irf7
T(co)F Pathway Name Source Gene Number
Irf7 TOLL_LIKE_RECEPTOR_4_TLR4_CASCADE REACTOME 118
Irf7 MYD88_INDEPENDENT_TLR4_CASCADE REACTOME 100
Irf7 TOLL_LIKE_RECEPTOR_9_TLR9_CASCADE REACTOME 94
Irf7 INNATE_IMMUNE_SYSTEM REACTOME 1087
Irf7 IMMUNE_SYSTEM REACTOME 1775
Irf7 TOLL_LIKE_RECEPTOR_CASCADES REACTOME 146
Irf7 DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA REACTOME 34
Irf7 CYTOSOLIC_SENSORS_OF_PATHOGEN_ASSOCIATED_DNA REACTOME 33
Irf7 DEX_H_BOX_HELICASES_ACTIVATE_TYPE_I_IFN_AND_INFLAM REACTOME 7
Irf7 ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSIL REACTOME 18
Irf7 APOPTOSIS WP 78
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of Irf7
T(co)F Expression in Mouse Cell (Fantom5) T(co)F Expression in Mouse Tissue (Fantom5)