T(co)F Overview
T(co)F: Sirt3
Species: Mus musculus
Knock-Method: knockout
T(co)F Class: Sirtuin
T(co)F Superclass: Chromatin Remodeling Factors
Biosample Name: pancreatic beta cell
Tissue Type: Pancreatic_islets
Biosample Type: Primary cell
# of Control: 6
# of Treat: 6
Data Source: GEO
Profile ID: GSE156345
Platform: GPL19057
Pubmed ID: -

Sirt3- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of Sirt3
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of Sirt3
Upstream Pathway Annotation of Sirt3
T(co)F Pathway Name Source Gene Number
Sirt3 MITOCHONDRIAL_BIOGENESIS REACTOME 28
Sirt3 ORGANELLE_BIOGENESIS_AND_MAINTENANCE REACTOME 212
Sirt3 GENERIC_TRANSCRIPTION_PATHWAY REACTOME 842
Sirt3 TRANSCRIPTIONAL_ACTIVATION_OF_MITOCHONDRIAL_BIOGEN REACTOME 11
Sirt3 GENE_EXPRESSION_TRANSCRIPTION REACTOME 1061
Sirt3 FOXO_MEDIATED_TRANSCRIPTION REACTOME 21
Sirt3 REGULATION_OF_FOXO_TRANSCRIPTIONAL_ACTIVITY_BY_ACE REACTOME 6
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of Sirt3
T(co)F Expression in Mouse Cell (Fantom5) T(co)F Expression in Mouse Tissue (Fantom5)