T(co)F Overview
T(co)F: Sirt6
Species: Mus musculus
Knock-Method: knockout
T(co)F Class: Sirtuin
T(co)F Superclass: Chromatin Remodeling Factors
Biosample Name: Liver
Tissue Type: Liver
Biosample Type: Tissue
# of Control: 6
# of Treat: 6
Data Source: GEO
Profile ID: GSE129370
Platform: GPL23479
Pubmed ID: -

Sirt6- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of Sirt6
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of Sirt6
Upstream Pathway Annotation of Sirt6
T(co)F Pathway Name Source Gene Number
Sirt6 DNA_DOUBLE_STRAND_BREAK_REPAIR REACTOME 160
Sirt6 HOMOLOGY_DIRECTED_REPAIR REACTOME 131
Sirt6 PROCESSING_OF_DNA_DOUBLE_STRAND_BREAK_ENDS REACTOME 88
Sirt6 DNA_REPAIR REACTOME 299
Sirt6 SREBF_AND_MIR33_IN_CHOLESTEROL_AND_LIPID_HOMEOSTAS WP 12
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of Sirt6
T(co)F Expression in Mouse Cell (Fantom5) T(co)F Expression in Mouse Tissue (Fantom5)