T(co)F Overview
T(co)F: Srf
Species: Mus musculus
Knock-Method: knockout
T(co)F Class: MADS box factors
T(co)F Superclass: alpha-Helices exposed by beta-structures
Biosample Name: Denate gyrus of hippocampus
Tissue Type: Brain
Biosample Type: Tissue
# of Control: 11
# of Treat: 11
Data Source: GEO
Profile ID: GSE60772
Platform: GPL17543
Pubmed ID: 25636686

Srf- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of Srf
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of Srf
Upstream Pathway Annotation of Srf
T(co)F Pathway Name Source Gene Number
Srf EGF_PATHWAY BIOCARTA 28
Srf GH_PATHWAY BIOCARTA 28
Srf IGF1_PATHWAY BIOCARTA 22
Srf IL6_PATHWAY BIOCARTA 22
Srf INSULIN_PATHWAY BIOCARTA 23
Srf PDGF_PATHWAY BIOCARTA 29
Srf MAL_PATHWAY BIOCARTA 18
Srf SIGNALING_BY_NTRKS REACTOME 75
Srf SIGNALING_BY_NTRK1_TRKA REACTOME 63
Srf RHO_GTPASE_EFFECTORS REACTOME 245
Srf NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACT REACTOME 27
Srf RHO_GTPASES_ACTIVATE_FORMINS REACTOME 135
Srf SIGNALING_BY_RECEPTOR_TYROSINE_KINASES REACTOME 401
Srf NGF_STIMULATED_TRANSCRIPTION REACTOME 6
Srf SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3 REACTOME 620
Srf HEART_DEVELOPMENT WP 46
Srf INSULIN_SIGNALING WP 158
Srf MAPK_SIGNALING_PATHWAY WP 159
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of Srf
T(co)F Expression in Mouse Cell (Fantom5) T(co)F Expression in Mouse Tissue (Fantom5)