T(co)F Overview
T(co)F: NFKB2
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Rel homology region (RHR) factors
T(co)F Superclass: Immunoglobulin fold
Biosample Name: U2OS
Tissue Type: Bone_marrow
Biosample Type: Cell line
# of Control: 3
# of Treat: 3
Data Source: GEO
Profile ID: GSE148511
Platform: GPL20301
Pubmed ID: 35689636

NFKB2- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of NFKB2
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of NFKB2
Upstream Pathway Annotation of NFKB2
T(co)F Pathway Name Source Gene Number
NFKB2 Alternative NF-kappaB pathway PID 6
NFKB2 IkBA variant leads to EDA-ID Reactome 7
NFKB2 Interleukin-1 processing Reactome 7
NFKB2 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) Reactome 8
NFKB2 DEx/H-box helicases activate type I IFN and inflammatory cytokines production Reactome 13
NFKB2 RIP-mediated NFkB activation via ZBP1 Reactome 21
NFKB2 TRAF6 mediated NF-kB activation Reactome 24
NFKB2 TSLP NetPath 24
NFKB2 TAK1 activates NFkB by phosphorylation and activation of IKKs complex Reactome 26
NFKB2 TWEAK NetPath 35
NFKB2 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine SMPDB 37
NFKB2 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine SMPDB 38
NFKB2 NIK-->noncanonical NF-kB signaling Reactome 58
NFKB2 Dectin-1 mediated noncanonical NF-kB signaling Reactome 61
NFKB2 Hs_TNF_alpha_Signaling_Pathway_WP231_89895 WikiPathways 61
NFKB2 IL12-mediated signaling events PID 62
NFKB2 RANKL NetPath 84
NFKB2 Apoptosis signaling pathway PANTHER 104
NFKB2 Inflammation mediated by chemokine and cytokine signaling pathway PANTHER 189
NFKB2 MAPK signaling pathway KEGG 264
NFKB2 TNFalpha NetPath 274
NFKB2 Pathways in cancer KEGG 321
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of NFKB2
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines