T(co)F Overview
T(co)F: ESR1
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Nuclear receptors with C4 zinc fingers
T(co)F Superclass: Zinc-coordinating DNA-binding domains
Biosample Name: Endometrial stromal cells
Tissue Type: Uterus
Biosample Type: Primary cell
# of Control: 2
# of Treat: 2
Data Source: GEO
Profile ID: GSE73550
Platform: GPL6244
Pubmed ID: 26849466

ESR1- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of ESR1
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of ESR1
Upstream Pathway Annotation of ESR1
T(co)F Pathway Name Source Gene Number
ESR1 Tamoxifen Action Pathway SMPDB 10
ESR1 Tamoxifen Metabolism Pathway SMPDB 10
ESR1 Hs_Estrogen_signaling_pathway_WP712_78491 WikiPathways 13
ESR1 Hs_Aryl_Hydrocarbon_Receptor_WP2586_91687 WikiPathways 16
ESR1 Nuclear signaling by ERBB4 Reactome 25
ESR1 Cellular roles of Anthrax toxin PID 25
ESR1 Signaling mediated by p38-alpha and p38-beta PID 35
ESR1 Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974 WikiPathways 36
ESR1 Hs_Leptin_signaling_pathway_WP2034_89856 WikiPathways 37
ESR1 Plasma membrane estrogen receptor signaling PID 42
ESR1 FOXM1 transcription factor network PID 43
ESR1 LKB1 signaling events PID 43
ESR1 FOXA1 transcription factor network PID 45
ESR1 Nuclear Receptor transcription pathway Reactome 51
ESR1 Signaling events mediated by HDAC Class II PID 58
ESR1 ATF-2 transcription factor network PID 59
ESR1 Validated nuclear estrogen receptor alpha network PID 65
ESR1 Regulation of Telomerase PID 70
ESR1 AP-1 transcription factor network PID 71
ESR1 Regulation of nuclear SMAD2/3 signaling PID 82
ESR1 Leptin NetPath 98
ESR1 Prolactin NetPath 105
ESR1 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 WikiPathways 122
ESR1 AndrogenReceptor NetPath 167
ESR1 TGF_beta_Receptor NetPath 220
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of ESR1
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines