T(co)F Overview
T(co)F: AGO2
Species: Homo sapiens
Knock-Method: shRNA
T(co)F Class: Others
T(co)F Superclass: TcoF-DB_TcoF
Biosample Name: K562
Tissue Type: Haematopoietic_and_lymphoid_tissue
Biosample Type: Cell line
# of Control: 2
# of Treat: 2
Data Source: ENCODE
Profile ID: ENCSR495YSS
Platform: -
Pubmed ID: 22955616

AGO2- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of AGO2
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of AGO2
Upstream Pathway Annotation of AGO2
T(co)F Pathway Name Source Gene Number
AGO2 Post-transcriptional silencing by small RNAs Reactome 7
AGO2 Small interfering RNA (siRNA) biogenesis Reactome 9
AGO2 MicroRNA (miRNA) biogenesis Reactome 23
AGO2 Pre-NOTCH Transcription and Translation Reactome 29
AGO2 Ca2+ pathway Reactome 62
AGO2 PIP3 activates AKT signaling Reactome 81
AGO2 TP53 Regulates Metabolic Genes Reactome 85
AGO2 MAPK6/MAPK4 signaling Reactome 90
AGO2 Transcriptional regulation by small RNAs Reactome 104
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of AGO2
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines