T(co)F Overview
T(co)F: WHSC1
Species: Homo sapiens
Knock-Method: CRISPRi
T(co)F Class: High-mobility group (HMG) domain factors
T(co)F Superclass: Other all-alpha-helical DNA-binding domains
Biosample Name: K562
Tissue Type: Haematopoietic_and_lymphoid_tissue
Biosample Type: Cell line
# of Control: 2
# of Treat: 4
Data Source: ENCODE
Profile ID: ENCSR181WYS
Platform: -
Pubmed ID: 22955616

WHSC1- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of WHSC1
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of WHSC1
Upstream Pathway Annotation of WHSC1
T(co)F Pathway Name Source Gene Number
WHSC1 Lysine degradation KEGG 44
WHSC1 PKMTs methylate histone lysines Reactome 64
WHSC1 Nonhomologous End-Joining (NHEJ) Reactome 69
WHSC1 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Reactome 75
WHSC1 G2/M DNA damage checkpoint Reactome 84
WHSC1 Processing of DNA double-strand break ends Reactome 98
WHSC1 AndrogenReceptor NetPath 167
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of WHSC1
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines