T(co)F Overview
T(co)F: NRF1
Species: Homo sapiens
Knock-Method: CRISPRi
T(co)F Class: Basic leucine zipper factors (bZIP)
T(co)F Superclass: Basic domains
Biosample Name: K562
Tissue Type: Haematopoietic_and_lymphoid_tissue
Biosample Type: Cell line
# of Control: 2
# of Treat: 3
Data Source: ENCODE
Profile ID: ENCSR299HUJ
Platform: -
Pubmed ID: 22955616

NRF1- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of NRF1
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of NRF1
Upstream Pathway Annotation of NRF1
T(co)F Pathway Name Source Gene Number
NRF1 Hs_Mitochondrial_Gene_Expression_WP391_71373 WikiPathways 11
NRF1 Hs_Energy_Metabolism_WP1541_91584 WikiPathways 13
NRF1 Transcriptional activation of mitochondrial biogenesis Reactome 43
NRF1 PPARA activates gene expression Reactome 113
NRF1 Huntington's disease KEGG 182
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of NRF1
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines