T(co)F Overview
T(co)F: UBTF
Species: Homo sapiens
Knock-Method: CRISPRi
T(co)F Class: High-mobility group (HMG) domain factors
T(co)F Superclass: Other all-alpha-helical DNA-binding domains
Biosample Name: K562
Tissue Type: Haematopoietic_and_lymphoid_tissue
Biosample Type: Cell line
# of Control: 2
# of Treat: 2
Data Source: ENCODE
Profile ID: ENCSR608ORR
Platform: -
Pubmed ID: 22955616

UBTF- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of UBTF
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of UBTF
Upstream Pathway Annotation of UBTF
T(co)F Pathway Name Source Gene Number
UBTF General transcription by RNA polymerase I PANTHER 15
UBTF RNA Polymerase I Promoter Escape Reactome 30
UBTF RNA Polymerase I Transcription Termination Reactome 31
UBTF RNA Polymerase I Transcription Initiation Reactome 47
UBTF RNA Polymerase I Promoter Opening Reactome 61
UBTF Regulation of retinoblastoma protein PID 67
UBTF Validated targets of C-MYC transcriptional activation PID 80
UBTF RNA Polymerase I Chain Elongation Reactome 88
UBTF NoRC negatively regulates rRNA expression Reactome 104
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of UBTF
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines