T(co)F Overview
T(co)F: MYC
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Basic helix-loop-helix factors (bHLH)
T(co)F Superclass: Basic domains
Biosample Name: HCT116
Tissue Type: Colon
Biosample Type: Cell line
# of Control: 4
# of Treat: 8
Data Source: GEO
Profile ID: GSE87693
Platform: GPL20844
Pubmed ID: 28847964

MYC- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of MYC
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of MYC
Upstream Pathway Annotation of MYC
T(co)F Pathway Name Source Gene Number
MYC Binding of TCF/LEF:CTNNB1 to target gene promoters Reactome 7
MYC Hs_TP53_Network_WP1742_71700 WikiPathways 10
MYC Hs_Imatinib_and_Chronic_Myeloid_Leukemia_WP3640_89384 WikiPathways 11
MYC Cyclin E associated events during G1/S transition Reactome 14
MYC Cyclin A:Cdk2-associated events at S phase entry Reactome 15
MYC Hs_IL-7_Signaling_Pathway_WP205_89854 WikiPathways 16
MYC Oxidative stress response PANTHER 23
MYC Thyroid cancer KEGG 25
MYC C-MYC pathway PID 25
MYC Hs_Gastric_Cancer_Network_2_WP2363_87523 WikiPathways 28
MYC Hs_miRNAs_involved_in_DNA_damage_response_WP1545_84697 WikiPathways 30
MYC IL2 signaling events mediated by STAT5 PID 30
MYC Hs_Association_Between_Physico-Chemical_Features_and_Toxicity_Associated_Pathways_WP3680_90113 WikiPathways 31
MYC Hs_Apoptosis_WP254_88977 WikiPathways 31
MYC SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Reactome 32
MYC Hs_IL-5_Signaling_Pathway_WP127_78498 WikiPathways 35
MYC Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974 WikiPathways 36
MYC Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640 WikiPathways 36
MYC CD40/CD40L signaling PID 36
MYC Bladder cancer KEGG 38
MYC IL2 signaling events mediated by PI3K PID 38
MYC Hs_Neural_Crest_Differentiation_WP2064_79263 WikiPathways 40
MYC p53 pathway feedback loops 2 PANTHER 42
MYC FOXM1 transcription factor network PID 43
MYC LKB1 signaling events PID 43
MYC Presenilin action in Notch and Wnt signaling PID 46
MYC NOTCH1 Intracellular Domain Regulates Transcription Reactome 47
MYC IL6-mediated signaling events PID 48
MYC Ceramide signaling pathway PID 49
MYC Endometrial cancer KEGG 52
MYC Hs_Prolactin_Signaling_Pathway_WP2037_90015 WikiPathways 52
MYC Acute myeloid leukemia KEGG 53
MYC IL2-mediated signaling events PID 54
MYC Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Reactome 57
MYC Constitutive Signaling by NOTCH1 PEST Domain Mutants Reactome 57
MYC Notch signaling pathway PID 58
MYC Colorectal cancer KEGG 63
MYC Validated targets of C-MYC transcriptional repression PID 63
MYC Validated nuclear estrogen receptor alpha network PID 65
MYC Chronic myeloid leukemia KEGG 69
MYC Regulation of Telomerase PID 70
MYC AP-1 transcription factor network PID 71
MYC E2F transcription factor network PID 77
MYC p73 transcription factor network PID 80
MYC Regulation of nuclear beta catenin signaling and target gene transcription PID 80
MYC Validated targets of C-MYC transcriptional activation PID 80
MYC TGF-beta signaling pathway KEGG 82
MYC Regulation of nuclear SMAD2/3 signaling PID 82
MYC ErbB signaling pathway KEGG 83
MYC Small cell lung cancer KEGG 83
MYC Interleukin signaling pathway PANTHER 86
MYC C-MYB transcription factor network PID 87
MYC Formation of the beta-catenin:TCF transactivating complex Reactome 88
MYC MAPK6/MAPK4 signaling Reactome 90
MYC Prolactin NetPath 105
MYC Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 WikiPathways 107
MYC PDGF signaling pathway PANTHER 113
MYC Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 WikiPathways 122
MYC Cell cycle KEGG 124
MYC PDGFR-beta signaling pathway PID 125
MYC Wnt signaling pathway KEGG 135
MYC Jak-STAT signaling pathway KEGG 149
MYC TGF_beta_Receptor NetPath 220
MYC MAPK signaling pathway KEGG 264
MYC Pathways in cancer KEGG 321
MYC EGFR1 NetPath 475
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of MYC
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines