T(co)F Overview
T(co)F: IRF7
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Tryptophan cluster factors
T(co)F Superclass: Helix-turn-helix domains
Biosample Name: Primary human bronchial epithelial cells
Tissue Type: Bronchus
Biosample Type: Primary cell
# of Control: 10
# of Treat: 10
Data Source: GEO
Profile ID: GSE70190
Platform: GPL20609
Pubmed ID: 26810609

IRF7- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of IRF7
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of IRF7
Upstream Pathway Annotation of IRF7
T(co)F Pathway Name Source Gene Number
IRF7 Hs_TLR4_Signaling_and_Tolerance_WP3851_90114 WikiPathways 8
IRF7 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Reactome 11
IRF7 DEx/H-box helicases activate type I IFN and inflammatory cytokines production Reactome 13
IRF7 TRAF3-dependent IRF activation pathway Reactome 14
IRF7 Hs_Toll-like_Receptor_Signaling_Pathway_WP75_83867 WikiPathways 17
IRF7 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Reactome 18
IRF7 TRAF6 mediated IRF7 activation Reactome 33
IRF7 Hs_Structural_Pathway_of_Interleukin_1_(IL-1)_WP2637_87707 WikiPathways 34
IRF7 Hs_Regulation_of_toll-like_receptor_signaling_pathway_WP1449_81172 WikiPathways 47
IRF7 Cytosolic DNA-sensing pathway KEGG 56
IRF7 Interferon alpha/beta signaling Reactome 67
IRF7 RIG-I-like receptor signaling pathway KEGG 71
IRF7 Regulation of nuclear SMAD2/3 signaling PID 82
IRF7 Interferon gamma signaling Reactome 88
IRF7 Toll-like receptor signaling pathway KEGG 100
IRF7 Factors involved in megakaryocyte development and platelet production Reactome 111
IRF7 Hepatitis C KEGG 134
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of IRF7
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines