T(co)F Overview
T(co)F: HMGA1
Species: Homo sapiens
Knock-Method: shRNA
T(co)F Class: A.T hook factors
T(co)F Superclass: beta-Sheet binding to DNA
Biosample Name: MDA-MB-231
Tissue Type: Mammary_gland
Biosample Type: Cell line
# of Control: 3
# of Treat: 3
Data Source: GEO
Profile ID: GSE45483
Platform: GPL5175
Pubmed ID: 23658826

HMGA1- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of HMGA1
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of HMGA1
Upstream Pathway Annotation of HMGA1
T(co)F Pathway Name Source Gene Number
HMGA1 APOBEC3G mediated resistance to HIV-1 infection Reactome 5
HMGA1 Integration of provirus Reactome 5
HMGA1 2-LTR circle formation Reactome 7
HMGA1 Formation of Senescence-Associated Heterochromatin Foci (SAHF) Reactome 17
HMGA1 Vpr-mediated nuclear import of PICs Reactome 33
HMGA1 Hs_Integrin-mediated_Cell_Adhesion_WP185_88160 WikiPathways 38
HMGA1 IL4-mediated signaling events PID 66
HMGA1 Validated targets of C-MYC transcriptional activation PID 80
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of HMGA1
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines