T(co)F Overview
T(co)F: GLI2
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: C2H2 zinc finger factors
T(co)F Superclass: Zinc-coordinating DNA-binding domains
Biosample Name: U2OS
Tissue Type: Bone_marrow
Biosample Type: Cell line
# of Control: 1
# of Treat: 1
Data Source: GEO
Profile ID: GSE42903
Platform: GPL6244
Pubmed ID: -

GLI2- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of GLI2
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of GLI2
Upstream Pathway Annotation of GLI2
T(co)F Pathway Name Source Gene Number
GLI2 GLI proteins bind promoters of Hh responsive genes to promote transcription Reactome 7
GLI2 Signaling without Hh ( Hedgehog signaling pathway ) INOH 7
GLI2 Ci/Gli processing signaling ( Hedgehog signaling pathway ) INOH 17
GLI2 Signaling events mediated by the Hedgehog family PID 24
GLI2 Hedgehog NetPath 39
GLI2 Hedgehog 'off' state Reactome 43
GLI2 Hedgehog signaling events mediated by Gli proteins PID 49
GLI2 Basal cell carcinoma KEGG 51
GLI2 Hedgehog signaling pathway KEGG 53
GLI2 Degradation of GLI2 by the proteasome Reactome 59
GLI2 Hedgehog 'on' state Reactome 72
GLI2 Pathways in cancer KEGG 321
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of GLI2
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines