T(co)F Overview
T(co)F: NANOG
Species: Homo sapiens
Knock-Method: shRNA
T(co)F Class: Homeo domain factors
T(co)F Superclass: Helix-turn-helix domains
Biosample Name: H1-hESC
Tissue Type: Embryo
Biosample Type: Stem cell
# of Control: 8
# of Treat: 8
Data Source: GEO
Profile ID: GSE34904
Platform: GPL10558
Pubmed ID: 22482508

NANOG- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of NANOG
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of NANOG
Upstream Pathway Annotation of NANOG
T(co)F Pathway Name Source Gene Number
NANOG POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation Reactome 10
NANOG POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Reactome 13
NANOG Transcriptional regulation of pluripotent stem cells Reactome 28
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of NANOG
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines