T(co)F Overview
T(co)F: PITX2
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Homeo domain factors
T(co)F Superclass: Helix-turn-helix domains
Biosample Name: TM2
Tissue Type: Eye
Biosample Type: Primary cell
# of Control: 2
# of Treat: 2
Data Source: GEO
Profile ID: GSE27275
Platform: GPL6883
Pubmed ID: -

PITX2- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of PITX2
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of PITX2
Upstream Pathway Annotation of PITX2
T(co)F Pathway Name Source Gene Number
PITX2 Hs_BMP_Signaling_Pathway_in_Eyelid_Development_WP3927_90735 WikiPathways 11
PITX2 Hs_Heart_Development_WP1591_90186 WikiPathways 28
PITX2 Regulation of nuclear beta catenin signaling and target gene transcription PID 80
PITX2 TGF-beta signaling pathway KEGG 82
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of PITX2
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines