T(co)F Overview
T(co)F: TP63
Species: Homo sapiens
Knock-Method: shRNA
T(co)F Class: p53 domain factors
T(co)F Superclass: Immunoglobulin fold
Biosample Name: MCF10A
Tissue Type: Mammary_gland
Biosample Type: Cell line
# of Control: 2
# of Treat: 4
Data Source: GEO
Profile ID: GSE20286
Platform: GPL571
Pubmed ID: 16715076/20194747

TP63- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of TP63
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of TP63
Upstream Pathway Annotation of TP63
T(co)F Pathway Name Source Gene Number
TP63 Hs_Hypothetical_Craniofacial_Development_Pathway_WP3655_88473 WikiPathways 5
TP63 P53 pathway feedback loops 1 PANTHER 6
TP63 Activation of PUMA and translocation to mitochondria Reactome 8
TP63 Hs_Urea_cycle_and_metabolism_of_amino_groups_WP497_72142 WikiPathways 8
TP63 TP53 Regulates Transcription of Caspase Activators and Caspases Reactome 12
TP63 TP53 Regulates Transcription of Death Receptors and Ligands Reactome 12
TP63 Regulation of TP53 Activity through Association with Co-factors Reactome 14
TP63 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Reactome 14
TP63 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Reactome 19
TP63 p53 pathway by glucose deprivation PANTHER 21
TP63 Hs_Focal_Adhesion_WP306_80308 WikiPathways 26
TP63 Hs_TGF-beta_Receptor_Signaling_WP560_90187 WikiPathways 28
TP63 p53 pathway PANTHER 39
TP63 p53 pathway feedback loops 2 PANTHER 42
TP63 Validated transcriptional targets of deltaNp63 isoforms PID 47
TP63 Validated transcriptional targets of TAp63 isoforms PID 54
TP63 p73 transcription factor network PID 80
TP63 TP53 Regulates Metabolic Genes Reactome 85
TP63 Huntington disease PANTHER 113
TP63 Direct p53 effectors PID 141
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of TP63
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines