TF Motif ID Region Strand Score PValue Sequences
HINFP Transfac.V$HINFP_02 chr8:22049161-22049180 +2.672418.5e-07GCGGAGCCCGGGCGGCCCGC
SP2 Transfac.V$SP2_Q3_01 chr8:22049227-22049241 +18.42861.56e-07GAGGAGGGCGGGGGC
KLF5 Transfac.V$BTEB2_Q3 chr8:22049227-22049242 +18.47961.29e-07GAGGAGGGCGGGGGCG
SP1 Transfac.V$SP1_Q4_01 chr8:22049229-22049241 +16.05269.48e-07GGAGGGCGGGGGC
SP2 Transfac.V$SP2_Q3 chr8:22049229-22049243 -19.26538.35e-08CCGCCCCCGCCCTCC
EGR4 JASPAR2020.MA0733.1 chr8:22049230-22049245 -16.92739.12e-07TCCCGCCCCCGCCCTC
EGR4 Jolma2013.EGR4_DBD chr8:22049230-22049245 -16.88899.24e-07TCCCGCCCCCGCCCTC
EGR4 Transfac.V$EGR4_01 chr8:22049230-22049245 -16.92739.12e-07TCCCGCCCCCGCCCTC
EGR1 Transfac.V$EGR1_06 chr8:22049231-22049244 -18.64632.42e-07CCCGCCCCCGCCCT
EGR1 Uniprobe.UP00007_1 chr8:22049231-22049244 -18.52292.5e-07CCCGCCCCCGCCCT
EGR3 JASPAR2020.MA0732.1 chr8:22049231-22049245 -178.97e-07TCCCGCCCCCGCCCT
EGR3 Jolma2013.EGR3_DBD chr8:22049231-22049245 -16.92869.07e-07TCCCGCCCCCGCCCT
EGR3 Transfac.V$EGR3_02 chr8:22049231-22049245 -178.97e-07TCCCGCCCCCGCCCT
EGR1 JASPAR2020.MA0162.4 chr8:22049232-22049245 -17.67483.36e-07TCCCGCCCCCGCCC
WT1 Transfac.V$WT1_Q6_01 chr8:22049233-22049242 -17.06743.39e-07CGCCCCCGCC
EGR1 Transfac.V$EGR1_Q6 chr8:22049234-22049243 +18.48683.39e-07GCGGGGGCGG
WT1 Transfac.V$WT1_Q6_02 chr8:22049234-22049245 +17.58434.07e-07GCGGGGGCGGGA
E2F6 JASPAR2020.MA0471.2 chr8:22049236-22049248 +18.23581.15e-08GGGGGCGGGAAGC
TFDP1 JASPAR2020.MA1122.1 chr8:22049238-22049248 +16.40374.54e-07GGGCGGGAAGC
SP1 Transfac.V$SP1_Q4_01 chr8:22049267-22049279 +16.01329.92e-07GGGGGGAGGGGGC
SP1 Transfac.V$SP1_Q6 chr8:22049267-22049279 +16.39479.27e-07GGGGGGAGGGGGC
SP2 Transfac.V$SP2_Q3 chr8:22049267-22049281 -18.88781.24e-07TCGCCCCCTCCCCCC
SP1 Transfac.V$SP1_03 chr8:22049268-22049277 -17.06747.52e-07CCCCTCCCCC
SP4 Transfac.V$SP4_Q5 chr8:22049268-22049278 -17.3988.65e-07CCCCCTCCCCC
ZNF148 JASPAR2020.MA1653.1 chr8:22049268-22049279 -19.47961.14e-07GCCCCCTCCCCC
MAZ JASPAR2020.MA1522.1 chr8:22049269-22049279 -17.97963.73e-07GCCCCCTCCCC
ZFX Transfac.V$ZFX_01 chr8:22049310-22049325 +17.01528.55e-07CGCGGGGCCGGGGCGG
PLAG1 Transfac.V$PLAG1_02 chr8:22049313-22049328 -19.47192.01e-07CCCCCGCCCCGGCCCC
SP1 Transfac.V$SP1_Q6_02 chr8:22049313-22049329 -18.6654.57e-09GCCCCCGCCCCGGCCCC
SP1 Transfac.V$SP1_Q6_02 chr8:22049314-22049330 -15.85442.7e-07GGCCCCCGCCCCGGCCC
SP2 Transfac.V$SP2_Q3_01 chr8:22049315-22049329 +17.73473.34e-07GGCCGGGGCGGGGGC
WT1 Transfac.V$WT1_Q6_02 chr8:22049316-22049327 +16.85397.62e-07GCCGGGGCGGGG
SP1 Transfac.V$SP1_Q4_01 chr8:22049317-22049329 +16.11848.24e-07CCGGGGCGGGGGC
SP1 Transfac.V$SP1_Q6 chr8:22049317-22049329 +16.52638.21e-07CCGGGGCGGGGGC
SP1 Transfac.V$SP1_Q2_01 chr8:22049318-22049327 -16.09216.78e-07CCCCGCCCCG
KLF15 JASPAR2020.MA1513.1 chr8:22049318-22049328 -18.01924.75e-07CCCCCGCCCCG
SP4 Transfac.V$SP4_Q5 chr8:22049318-22049328 -18.58163.06e-07CCCCCGCCCCG
SP1 Transfac.V$SP1_Q6_01 chr8:22049319-22049328 +15.98576.78e-07GGGGCGGGGG
SP1 Transfac.V$SP1_02 chr8:22049319-22049329 +18.73391.53e-07GGGGCGGGGGC
SP2 Transfac.V$SP2_Q3_01 chr8:22049396-22049410 +16.79598.71e-07GAGAGGGGCGGGGAG
SMAD3 Transfac.V$SMAD4_04 chr8:22049396-22049412 -171.34e-07TCCTCCCCGCCCCTCTC
SMAD3 Uniprobe.UP00000_2 chr8:22049396-22049412 -16.98391.24e-07TCCTCCCCGCCCCTCTC
SP2 Transfac.V$SP2_Q3 chr8:22049398-22049412 -17.62244.74e-07TCCTCCCCGCCCCTC
SP1 Transfac.V$SP1_01 chr8:22049400-22049409 +14.39458.26e-07GGGGCGGGGA
SP1 Transfac.V$SP1_02 chr8:22049400-22049410 +18.30283.39e-07GGGGCGGGGAG
MAZ Transfac.V$MAZ_Q6_01 chr8:22049404-22049417 +16.77539.49e-07CGGGGAGGAAGGGG
SP1 Transfac.V$SP1_02 chr8:22049425-22049435 -17.86247.88e-07GGGGTGGGGGC
HOXB9 Homeodomain.UP00207_1 chr8:22049495-22049510 +18.3783.58e-08GGGGCCATAAAACCCG
HOXB9 Transfac.V$HOXB9_01 chr8:22049495-22049510 +18.3963.62e-08GGGGCCATAAAACCCG
HOXB9 Uniprobe.UP00207_1 chr8:22049495-22049510 +18.3783.58e-08GGGGCCATAAAACCCG
CDX1 JASPAR2020.MA0878.2 chr8:22049497-22049507 +17.8982.49e-07GGCCATAAAAC
CDX4 JASPAR2020.MA1473.1 chr8:22049497-22049507 +17.32.49e-07GGCCATAAAAC
HOXA11 Jolma2013.Hoxa11_DBD_2 chr8:22049497-22049507 +12.98042.49e-07GGCCATAAAAC
HOXA11 Transfac.V$HOXA11_04 chr8:22049497-22049507 +13.01492.49e-07GGCCATAAAAC
ZNF740 JASPAR2020.MA0753.2 chr8:22049567-22049579 +17.65177.19e-07CAACCCCCCCCCC
ZNF740 Transfac.V$ZFP740_03 chr8:22049567-22049582 +16.86593.52e-07CAACCCCCCCCCCCCG
SP1 Transfac.V$SP1_Q6_02 chr8:22049567-22049583 +16.03882.14e-07CAACCCCCCCCCCCCGC
KLF5 Transfac.V$BTEB2_Q3 chr8:22049568-22049583 -16.97966.75e-07GCGGGGGGGGGGGGTT
SP1 Transfac.V$SP1_Q6_02 chr8:22049568-22049584 +16.85927.16e-08AACCCCCCCCCCCCGCC
ZNF740 JASPAR2020.MA0753.2 chr8:22049569-22049581 +17.48317.85e-07ACCCCCCCCCCCC
ZNF740 Transfac.V$ZFP740_03 chr8:22049569-22049584 +17.51.38e-07ACCCCCCCCCCCCGCC
SP1 Transfac.V$SP1_Q6_02 chr8:22049569-22049585 +16.64569.67e-08ACCCCCCCCCCCCGCCA
SP2 Transfac.V$SP2_Q3_01 chr8:22049570-22049584 -16.98987.27e-07GGCGGGGGGGGGGGG
SP1 Transfac.V$SP1_Q6_02 chr8:22049570-22049586 +18.0341.28e-08CCCCCCCCCCCCGCCAC
ZNF740 JASPAR2020.MA0753.2 chr8:22049571-22049583 +17.3828.7e-07CCCCCCCCCCCGC
MAZ Transfac.V$MAZ_Q6_01 chr8:22049571-22049584 -18.50561.49e-07GGCGGGGGGGGGGG
SP1 Transfac.V$SP1_Q6_02 chr8:22049571-22049587 +18.61654.96e-09CCCCCCCCCCCGCCACC
SP1 Transfac.V$SP1_Q6_02 chr8:22049572-22049588 +15.6993.28e-07CCCCCCCCCCGCCACCC
SP1 Transfac.V$SP1_Q6_02 chr8:22049573-22049589 +16.41261.31e-07CCCCCCCCCGCCACCCC
RREB1 JASPAR2020.MA0073.1 chr8:22049573-22049592 +15.97257.97e-07CCCCCCCCCGCCACCCCACC
SP1 Transfac.V$SP1_Q6_02 chr8:22049574-22049590 +15.22825.83e-07CCCCCCCCGCCACCCCA
SREBF2 Transfac.V$SREBP2_Q6 chr8:22049580-22049591 +12.72454.95e-07CCGCCACCCCAC
TFAP2A Transfac.V$AP2_Q6_01 chr8:22053851-22053863 -15.85866.5e-07CAGGCCCCAGGCG
MYF6 Transfac.V$MYF6_03 chr8:22053870-22053885 -16.95121.03e-07GAACAACAGGTGCCTG
MYF6 Uniprobe.UP00036_1 chr8:22053870-22053885 -16.86991.09e-07GAACAACAGGTGCCTG
ZNF263 JASPAR2020.MA0528.2 chr8:22053980-22053991 +17.23641.65e-07AGGGGGAGGAGG
ZNF263 Transfac.V$FPM315_01 chr8:22053981-22053992 +18.22731.77e-07GGGGGAGGAGGC
E2F6 JASPAR2020.MA0471.2 chr8:22056801-22056813 -16.58547.17e-07GGGGGCGGGAGGG
KLF4 JASPAR2020.MA0039.4 chr8:22056883-22056894 -16.47.62e-07GCCCCCACCCTC
PLAG1 JASPAR2020.MA0163.1 chr8:22056890-22056903 +20.28571.29e-07GGGGCCCAGAGGGG
KLF11 Transfac.V$FKLF_Q5 chr8:22056947-22056956 -14.99089.16e-07GGGGTGGGAG
SP2 Transfac.V$SP2_Q3 chr8:22056949-22056963 +17.54085.2e-07CCCACCCCGCCCACC
SP3 JASPAR2020.MA0746.2 chr8:22056951-22056963 +17.84626.12e-07CACCCCGCCCACC
SP1 Transfac.V$SP1_Q6 chr8:22056951-22056963 -16.55268.02e-07GGTGGGCGGGGTG
SP1 Jolma2013.SP1_DBD chr8:22056952-22056962 +16.31635.83e-07ACCCCGCCCAC
SP1 Transfac.V$SP1_05 chr8:22056952-22056962 +16.34625.83e-07ACCCCGCCCAC
SP9 JASPAR2020.MA1564.1 chr8:22056952-22056963 +17.39663.22e-07ACCCCGCCCACC
GLI1 Transfac.V$GLI_Q6 chr8:22056952-22056966 +19.22942.07e-07ACCCCGCCCACCCAC
WT1 Transfac.V$WT1_Q6_02 chr8:22056953-22056964 -16.92137.06e-07GGGTGGGCGGGG
EGR1 JASPAR2020.MA0162.4 chr8:22056953-22056966 +17.44724.29e-07CCCCGCCCACCCAC
EGR4 JASPAR2020.MA0733.1 chr8:22056953-22056968 +17.36366.33e-07CCCCGCCCACCCACCC
EGR4 Jolma2013.EGR4_DBD chr8:22056953-22056968 +17.33336.35e-07CCCCGCCCACCCACCC
EGR1 Transfac.V$EGR1_08 chr8:22056953-22056968 +19.55173.34e-07CCCCGCCCACCCACCC
EGR4 Transfac.V$EGR4_01 chr8:22056953-22056968 +17.36366.33e-07CCCCGCCCACCCACCC
ZNF350 Transfac.V$ZBRK1_01 chr8:22057182-22057196 +17.31639.17e-07GGGCCACAGCGCTTG
NHLH1 Transfac.V$HEN1_01 chr8:22057280-22057301 -17.42117.56e-07ATCAGGCCCAGCTGGTCCCAGG
ZNF684 JASPAR2020.MA1600.1 chr8:22057432-22057449 -19.36071.61e-07CCACAGTCCATCCCTTCC
TFAP2A JASPAR2020.MA0003.4 chr8:22057554-22057567 -16.66676.75e-07ACAGCCTCAGGCCC
TFAP2C JASPAR2020.MA0814.2 chr8:22057554-22057567 +17.08134.76e-07GGGCCTGAGGCTGT
KLF5 JASPAR2020.MA0599.1 chr8:22057636-22057645 -16.67357.52e-07GCCCCACCCC
NHLH1 Transfac.V$HEN1_02 chr8:22057667-22057688 +17.67115.35e-07GCAGGGCGCAGCTGCAAGCCCA
TP73 Transfac.V$P73_Q6 chr8:22057672-22057691 -16.92868.01e-07GCTTGGGCTTGCAGCTGCGC
HIC1 Transfac.V$HIC1_02 chr8:22057701-22057715 +15.21055.52e-07CCCCTGTGCCCGCCG
TFAP4 Transfac.V$AP4_Q6_02 chr8:22057707-22057719 -15.0518.7e-07CCAGCGGCGGGCA
SMAD3 Transfac.V$SMAD3_Q6_01 chr8:22057829-22057841 +14.24729.9e-07GGGCAGACACACC
MYB Transfac.V$CMYB_Q5 chr8:22057915-22057925 -12.78657.26e-07CCCAACTGCCT
MYB JASPAR2020.MA0100.3 chr8:22057916-22057925 -13.5416.13e-07CCCAACTGCC
ZNF16 JASPAR2020.MA1654.1 chr8:22057933-22057955 +14.69358.25e-07AATGGGGAGCCCAGGGAAGGCCT
HIC1 Jolma2013.Hic1_DBD chr8:22058103-22058120 -25.16333.5e-09GTGCCAGCTCATGCCCCC
HIC1 Transfac.V$HIC1_07 chr8:22058103-22058120 -25.25863.42e-09GTGCCAGCTCATGCCCCC
MAZ Transfac.V$MAZ_Q6_01 chr8:22058485-22058498 +17.73033.64e-07GTGGGTGGAGAGGG
ZNF460 JASPAR2020.MA1596.1 chr8:22058889-22058904 +17.53934.44e-07GCCTCAGCCTCCTGGT
ZNF219 Transfac.V$ZNF219_01 chr8:22058918-22058929 -19.33712.75e-07CACCCCCCCGCC
SP1 Transfac.V$SP1_Q6_02 chr8:22058918-22058934 -16.20871.72e-07CCCCGCACCCCCCCGCC
ZNF423 Transfac.V$ROAZ_01 chr8:22058975-22058988 -16.75512.42e-07GCTCCCATGGGTGC
ZNF423 Transfac.V$ROAZ_01 chr8:22058975-22058988 +16.82652.09e-07GCACCCATGGGAGC
MAZ JASPAR2020.MA1522.1 chr8:22059031-22059041 +17.28574.86e-07TGCCCCTCCCC
MAZ Transfac.V$MAZ_Q6_01 chr8:22059034-22059047 -17.85393.21e-07CTGGGTGGGGAGGG
RFX1 Transfac.V$RFX1_02 chr8:22059106-22059123 -16.56127.77e-07CAGTTACTGTGGCAACAA
EGR1 Transfac.V$EGR1_06 chr8:22059120-22059133 -17.26838.32e-07CCCACCCCCGCAGT
EGR1 Uniprobe.UP00007_1 chr8:22059120-22059133 -17.09179.07e-07CCCACCCCCGCAGT
WT1 Transfac.V$WT1_Q6_02 chr8:22059123-22059134 +17.64043.69e-07GCGGGGGTGGGG
SP1 Jolma2013.SP1_DBD chr8:22059125-22059135 -16.09187.89e-07GCCCCACCCCC
SP1 Transfac.V$SP1_05 chr8:22059125-22059135 -16.13467.89e-07GCCCCACCCCC
KLF4 JASPAR2020.MA0039.4 chr8:22059125-22059136 -16.92.28e-07AGCCCCACCCCC
KLF5 JASPAR2020.MA0599.1 chr8:22059126-22059135 -16.67357.52e-07GCCCCACCCC
FLI1 JASPAR2020.MA0149.1 chr8:22059158-22059175 +6.723685.01e-07GGAAAGAGGGAGGGAGGG
MAZ Transfac.V$MAZ_Q6_01 chr8:22059163-22059176 +16.97757.75e-07GAGGGAGGGAGGGA
ZNF713 Transfac.V$ZNF713_01 chr8:22059183-22059199 +13.08162.73e-07ATGAAGAAAGCCAAGAA
HNF4A Transfac.V$HNF4_01 chr8:22059289-22059307 +15.93949.35e-07AGCGGGGCAAAGTTCCCTG
TFAP2A JASPAR2020.MA0003.4 chr8:22059575-22059588 +16.44729.45e-07TTGGCCTCAGGCAG
ZBTB7B Transfac.V$ZBTB7B_03 chr8:22059616-22059630 -16.97371.84e-07AGGCCCCCCAAATAG
ZBTB7B Uniprobe.UP00047_1 chr8:22059616-22059630 -16.8442.07e-07AGGCCCCCCAAATAG
SP2 JASPAR2020.MA0516.2 chr8:22059924-22059940 -20.72736.92e-08ATAAGACCCGCCCACTG
RREB1 JASPAR2020.MA0073.1 chr8:22059973-22059992 -23.35781.38e-08CCCCACCTCACCCACCACCC
GATA1 Transfac.V$GATA1_Q6 chr8:22060003-22060017 +12.759.45e-07GGCTCAGATAAGGCA
GATA5 JASPAR2020.MA0766.2 chr8:22060007-22060016 +13.61229.09e-07CAGATAAGGC
KLF5 Transfac.V$BTEB2_Q3 chr8:22060032-22060047 +17.38784.41e-07GGGGAGGGTGGGGCTG
KLF4 Transfac.V$GKLF_02 chr8:22060034-22060045 -17.39395.2e-07GCCCCACCCTCC
KLF4 JASPAR2020.MA0039.4 chr8:22060035-22060046 -16.33648.95e-07AGCCCCACCCTC
HIC1 Jolma2013.Hic1_DBD chr8:22060643-22060660 -17.53063.49e-07GTGCCACCCCCTGCCATT
HIC1 Transfac.V$HIC1_07 chr8:22060643-22060660 -17.44833.38e-07GTGCCACCCCCTGCCATT
NR2C2 JASPAR2020.MA0504.1 chr8:22060761-22060775 +17.27148.97e-07AGAGGTGAGAGGCCA
TBX2 Transfac.V$TBX2_Q2 chr8:22061004-22061013 -17.47157.46e-07AGGTGTGAGC
ZNF460 JASPAR2020.MA1596.1 chr8:22061027-22061042 -19.89891.15e-07ACCTCTGCCTCCCAAA
ZNF460 JASPAR2020.MA1596.1 chr8:22061173-22061188 -21.03375.63e-08GCCTCAGTCTCCCGAG
ZNF135 JASPAR2020.MA1587.1 chr8:22061206-22061219 -20.51029.74e-08CCTTGACCTCCCAG
RXRA Jolma2013.Rxra_DBD chr8:22061513-22061526 -17.46946.42e-07GAGGTGAAAGGTGA
MZF1 Transfac.V$MZF1_02 chr8:22061570-22061582 -14.98999.88e-07GGGGGAGGGGCAC
MAZ JASPAR2020.MA1522.1 chr8:22061571-22061581 +17.28574.86e-07TGCCCCTCCCC
ZNF148 JASPAR2020.MA1653.1 chr8:22061571-22061582 +19.26531.4e-07TGCCCCTCCCCC
SP4 Transfac.V$SP4_Q5 chr8:22061572-22061582 +18.20413.99e-07GCCCCTCCCCC
SP1 Transfac.V$SP1_03 chr8:22061573-22061582 +17.06747.52e-07CCCCTCCCCC
ZIC2 Transfac.V$ZIC2_04 chr8:22061577-22061591 +16.69825.18e-07TCCCCCCGGTGGTGT
ZIC3 Transfac.V$ZIC3_04 chr8:22061577-22061591 +16.62575.4e-07TCCCCCCGGTGGTGT
ZIC3 Uniprobe.UP00006_1 chr8:22061577-22061591 +16.67655.39e-07TCCCCCCGGTGGTGT
ZIC2 Uniprobe.UP00057_1 chr8:22061577-22061591 +16.77514.7e-07TCCCCCCGGTGGTGT
VDR Transfac.V$VDR_Q3 chr8:22061647-22061661 -17.72738.27e-08GGGGCAGGAGGGAGA
EGR1 Transfac.V$EGR1_Q6 chr8:22067021-22067030 -18.48683.39e-07GCGGGGGCGG
SP2 Transfac.V$SP2_Q3 chr8:22067021-22067035 +19.22458.76e-08CCGCCCCCGCCCCGC
SP1 Transfac.V$SP1_Q6_02 chr8:22067021-22067037 +15.24765.71e-07CCGCCCCCGCCCCGCTC
WT1 Transfac.V$WT1_Q6_01 chr8:22067022-22067031 +17.06743.39e-07CGCCCCCGCC
SP1 Transfac.V$SP1_Q6_02 chr8:22067022-22067038 +15.65533.47e-07CGCCCCCGCCCCGCTCC
SP1 Transfac.V$SP1_02 chr8:22067023-22067033 -18.73391.53e-07GGGGCGGGGGC
SP1 Transfac.V$SP1_Q4_01 chr8:22067023-22067035 -16.55.2e-07GCGGGGCGGGGGC
SP1 Transfac.V$SP1_Q6 chr8:22067023-22067035 -17.26323.69e-07GCGGGGCGGGGGC
SP2 Transfac.V$SP2_Q3_01 chr8:22067023-22067037 -18.54081.37e-07GAGCGGGGCGGGGGC
SP1 Transfac.V$SP1_Q6_02 chr8:22067023-22067039 +17.88831.6e-08GCCCCCGCCCCGCTCCC
SP1 Transfac.V$SP1_Q6_01 chr8:22067024-22067033 -15.98576.78e-07GGGGCGGGGG
KLF15 JASPAR2020.MA1513.1 chr8:22067024-22067034 +18.01924.75e-07CCCCCGCCCCG
SP4 Transfac.V$SP4_Q5 chr8:22067024-22067034 +18.58163.06e-07CCCCCGCCCCG
SP1 Transfac.V$SP1_Q2_01 chr8:22067025-22067034 +16.09216.78e-07CCCCGCCCCG
SP1 Transfac.V$SP1_Q6_02 chr8:22067025-22067041 +15.16996.26e-07CCCCGCCCCGCTCCCGC
MYCN Transfac.V$NMYC_Q3 chr8:22067048-22067057 -15.98175.03e-07GGGCACGTGC
RFX1 Transfac.V$RFX1_Q6 chr8:22067075-22067088 -17.26532.67e-07GTTGCTGGGGAGAG
REST Transfac.V$NRSF_01 chr8:22067148-22067168 +8.797758.05e-07TCCAGCATCGTGGTGAGTACC
ZNF219 Transfac.V$ZNF219_01 chr8:22067196-22067207 -20.02251.52e-07CTCCCCCCTCCC
SP1 Transfac.V$SP1_Q6_02 chr8:22067196-22067212 -14.86418.96e-07CCACCCTCCCCCCTCCC
RREB1 JASPAR2020.MA0073.1 chr8:22067196-22067215 -17.76153.63e-07CCCCCACCCTCCCCCCTCCC
KLF17 JASPAR2020.MA1514.1 chr8:22067200-22067214 -17.81636.63e-07CCCCACCCTCCCCCC