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TRCirc provides a comprehensive data source for integrating current transcription factors binding sites and circRNA annotations. The current release of TRCirc contains approximately 92375 human circRNAs and 690 ChIP-seq data sets across 91 human cell lines for 161 unique regulatory factors.Moreover, TRCirc provides other information of circRNAs, such as enhancer, methylation level, H3K27ac signal and expression. TF2LncRNA is an efficient and easy-to-use web-based tool.  1.TRCirc collected circRNA annotations and ChIP-seq and RNA-seq data sets from circBase and ENCODE, respectively. 2.TRCirc defined a region from 2kb upstream to 1kb downstream of the transcription start site of each circRNA as its regulatory region based on previous research. Meanwhile, we defined other regulatory regions, such as -10kb/1kb,-20kb/1kb, -30kb/2kb in the database. 3.TF-CircRNA regulatory relationships: Mapped transcription factors binding sites to regulatory region of circRNA. 4.TRCirc also include other information of circRNAs:super-enhancer, methylation, H3K27ac signal, junction reads and RPKM. 5.TRCirc provided visualization of network that about TFs-circRNA regulatory relationship in each cell lines. 6.TRCirc also provided visualization about expression of circRNA. 7.TRCirc JBrowse was developed to visualize transcriptional regulation information of circRNA. Advanced SearchIn this search entrance, accurate search is supported. User can specify the detailed information about circRNAs such as species, cell type, cell, regulation regions and circRNA name etc.  Class: Cell type Cell: Cell lines CircRNA: CircRNA ID Regulation_region:Promoter of circRNAs (-2Kb/1Kb, -10Kb/1Kb, -20Kb/1Kb and -30Kb/2Kb of a TSS) TF: Number of transcription factor which regulate that circRNA SE/TE: Number of enhancer(super-enhancer and typical enhancer) which regulate that circRNA Methylation: Mean of methylation level of that circRNA H3K27ac: H3K27ac signal in regulatory region (±1Kb of a TSS) of that circRNA Junction_read: Quantification of circRNA expression by junction reads RPKM-circRNA: Quantification of circRNA expression by reads of body region RPKM-gene: Quantification of host gene expression by reads of body region Search and Browse TF-circRNAs Regulatory Relationship by TF Cell_lines_name: All cell lines for this transcription factor Official_symbol: Official name of Transcription factor antibody: Corresponding antibody for transcription factor in each Chip-seq experiment TF_peak: Transcription factor binding site of regulatory region of circRNA CircRNA_name: CircRNA ID CircRNA_TSS: Transcription start sites of circRNA Strand: +; - Distance_peak2TSS: Distance between peak center and TSS of circRNA. Search and Browse TF-circRNAs Regulatory Relationship by Cell Lines Cell_lines_name: All cell lines for this transcription factor Official_symbol: Official name of Transcription factor antibody: Corresponding antibody for transcription factor in each Chip-seq experiment TF_peak: Transcription factor binding site of regulatory region of circRNA. CircRNA_name: CircRNA ID CircRNA_TSS: Transcription start sites of circRNA Strand: +; - Distance_peak2TSS: Distance between peak center and TSS of circRNA Search and Browse Methylation State of circRNAs Score: Scores associated with each site are beta values multiplied by 1000 Search and Browse enhancer which association with circRNAs SE/TE: Super-enhancer or typical enhancer which regulate that circRNA isSuper: Whether is super-enhancer VisualizationIn this search entrance, User can specify the information about circRNAs such as species, cell, regulation regions and circRNA name etc. User can obtain visualization of TF-circRNA network and expression of that circRNA.To arise user experience, TRCirc providing visualization of one circRNAs at a time. Moreover, JBrowse was used to visualize transcriptional regulation information of circRNA. Data Visualization  #TFs that in table correspond with TFs in network of bottom JBrowse JBrowse was used to visualize transcriptional regulation information of circRNA.Including the enhancer, TFBS, methylation and common SNP.  You can download TF-CircRNA regulatory relationships of four classes regulatory region by transcription factor and cell lines. And you can download TF-CircRNA pairs of four classes regulatory region, which does not distinguish transcription factor and cell line. Furthermore, user can download comprehensive information of circRNA and expression (standardization by H3K27ac signal, junction reads and body reads) of circNRAs.  |