General Details

Super-enhancer:SE_00_02600835
Genomic Locus: chr17: 62222475-62237029
Size/Length:14554bp
Conservation:0.046518
BioSample Type:Tissue
Tissue Type:Muscle of trunk
Sample Name:muscle-of-trunk
Source:Roadmap
Element:4
Rank:835
ChIP Density(Case):12068.1768
ChIP Density(Input):1408.8272

Super-enhancer Associated Network


* The complex regulatory networks formed by this SE , SE associated genes , TFs binding to the SE and their upstream pathways can be interactively visualized.


Fimo:
SE-Gene Linking Strategies:
Pathway Enriciment Threshold:
Top Pathway:
 



Super-enhancer Associated Statistics

Associated Gene Details

ROSE Overlap:SNORA76,SNORD104,TEX2
ROSE Proximal:ERN1
ROSE Closest:SNORA76
The Closest Active:SNORA76

Factors Binding to Super-enhancer




Using these SE element regions to analyze by online tools GREAT *The TFs binding to this SE identified by ChIP-seq.

Chrome Element_Start Element_End TF TF Source TF_Start TF_End TF Class Master TF

Using these SE element regions to analyze by online tools GREAT * The TFs binding to this SE predicted by Motif.

Chrome Element_Start Element_End TF Database TF_Start TF_End Score P_Value TF Class Master TF
chr17 62225182 62226227 ASCL2 Transfac.V$ASCL2_04 62225533 62225548 12.53850 6.17e-07 Basic domains N
chr17 62235055 62237029 ASCL2 Transfac.V$ASCL2_04 62236777 62236792 12.29120 9.78e-07 Basic domains N
chr17 62225182 62226227 ASCL2 Uniprobe.UP00099_2 62225533 62225548 12.43500 6.64e-07 Basic domains N
chr17 62235055 62237029 BCL6 Transfac.V$BCL6_Q3_01 62236602 62236611 14.73740 8.71e-07 Zinc-coordinating DNA-binding domains N
chr17 62231938 62234669 CDX1 Transfac.V$CDX1_01 62234522 62234537 18.40400 6.82e-08 Helix-turn-helix domains N
chr17 62231938 62234669 CDX1 Homeodomain.UP00240_1 62234522 62234537 18.36940 6.56e-08 Helix-turn-helix domains N
chr17 62231938 62234669 CDX1 Uniprobe.UP00240_1 62234522 62234537 18.36940 6.56e-08 Helix-turn-helix domains N
chr17 62231938 62234669 CDX2 Transfac.V$CDX2_01 62234522 62234537 17.70710 1.89e-07 Helix-turn-helix domains N
chr17 62231938 62234669 CDX2 Homeodomain.UP00133_1 62234522 62234537 17.67680 1.95e-07 Helix-turn-helix domains N
chr17 62231938 62234669 CDX2 Uniprobe.UP00133_1 62234522 62234537 17.67680 1.95e-07 Helix-turn-helix domains N
chr17 62231938 62234669 EOMES Transfac.V$EOMES_03 62234090 62234106 17.28920 5.5e-07 Immunoglobulin fold N
chr17 62231938 62234669 EOMES Uniprobe.UP00068_1 62234090 62234106 17.18920 5.83e-07 Immunoglobulin fold N
chr17 62222475 62224916 FOXJ2 Transfac.V$FOXJ2_01 62224807 62224824 16.84440 7.18e-07 Helix-turn-helix domains N
chr17 62231938 62234669 GFI1B JASPAR2014.MA0483.1 62232642 62232652 16.74140 8.9e-07 Zinc-coordinating DNA-binding domains N
chr17 62225182 62226227 HNF4A Transfac.V$HNF4A_02 62225926 62225941 17.63860 5.02e-07 Zinc-coordinating DNA-binding domains N
chr17 62235055 62237029 HNF4A Transfac.V$HNF4A_08 62235876 62235890 16.85450 5.91e-07 Zinc-coordinating DNA-binding domains N
chr17 62235055 62237029 HNF4A Jolma2013.HNF4A_full_4 62235876 62235890 16.96970 5.81e-07 Zinc-coordinating DNA-binding domains N
chr17 62225182 62226227 HNF4A Uniprobe.UP00066_2 62225926 62225941 17.54050 5.03e-07 Zinc-coordinating DNA-binding domains N
chr17 62231938 62234669 HOXA10 Transfac.V$HOXA10_01 62234521 62234536 18.21000 5.29e-08 Helix-turn-helix domains N
chr17 62231938 62234669 HOXA10 Homeodomain.UP00217_1 62234521 62234536 18.24000 5.52e-08 Helix-turn-helix domains N
chr17 62231938 62234669 HOXA10 Uniprobe.UP00217_1 62234521 62234536 18.24000 5.52e-08 Helix-turn-helix domains N
chr17 62225182 62226227 HOXB5 Transfac.V$HOXB5_03 62225383 62225392 10.83870 7.63e-07 Helix-turn-helix domains N
chr17 62225182 62226227 HOXB5 Jolma2013.HOXB5_DBD 62225383 62225392 10.80810 7.63e-07 Helix-turn-helix domains N
chr17 62231938 62234669 LHX2 Jolma2013.LHX2_DBD_2 62234594 62234608 16.91200 9.98e-07 Helix-turn-helix domains N
chr17 62235055 62237029 MAZ Transfac.V$MAZ_Q6_01 62236774 62236787 16.39560 9.48e-07 Zinc-coordinating DNA-binding domains N
chr17 62222475 62224916 NR0B1 Transfac.V$DAX1_01 62222853 62222872 15.53010 9.7e-07 Zinc-coordinating DNA-binding domains N
chr17 62231938 62234669 PDX1 Transfac.V$IPF1_Q5_01 62234594 62234603 11.10840 8.71e-07 Helix-turn-helix domains N
chr17 62231938 62234669 PLAG1 JASPAR2014.MA0163.1 62233475 62233488 17.41000 9.12e-07 Zinc-coordinating DNA-binding domains N
chr17 62235055 62237029 RARA Transfac.V$RARA_03 62235878 62235893 17.28920 4.01e-07 Zinc-coordinating DNA-binding domains N
chr17 62231938 62234669 RARA Transfac.V$RARA_07 62234530 62234546 20.49090 7.45e-08 Zinc-coordinating DNA-binding domains N
chr17 62231938 62234669 RARA Jolma2013.RARA_DBD_3 62234530 62234546 20.18000 8.93e-08 Zinc-coordinating DNA-binding domains N
chr17 62231938 62234669 RARA Jolma2013.RARA_full_3 62234530 62234546 20.45450 7.52e-08 Zinc-coordinating DNA-binding domains N
chr17 62231938 62234669 RARA Jolma2013.Rara_DBD_2 62234530 62234546 20.04040 9.94e-08 Zinc-coordinating DNA-binding domains N
chr17 62235055 62237029 RARA Uniprobe.UP00048_1 62235878 62235893 17.21210 4.34e-07 Zinc-coordinating DNA-binding domains N
chr17 62231938 62234669 RARB Jolma2013.Rarb_DBD_3 62234530 62234546 19.50510 8.35e-08 Zinc-coordinating DNA-binding domains N
chr17 62231938 62234669 RARG Transfac.V$RARG_02 62234530 62234547 17.84510 2.64e-07 Zinc-coordinating DNA-binding domains N
chr17 62235055 62237029 RARG Jolma2013.RARG_DBD 62235875 62235891 15.14140 7.5e-07 Zinc-coordinating DNA-binding domains N
chr17 62231938 62234669 RARG Jolma2013.RARG_DBD_2 62234530 62234547 20.62630 7.93e-08 Zinc-coordinating DNA-binding domains N
chr17 62231938 62234669 RARG Jolma2013.RARG_full_2 62234530 62234547 17.83840 2.78e-07 Zinc-coordinating DNA-binding domains N
chr17 62231938 62234669 RARG Jolma2013.Rarg_DBD_2 62234530 62234547 20.50510 4.28e-08 Zinc-coordinating DNA-binding domains N
chr17 62231938 62234669 REST Transfac.V$REST_Q5 62232533 62232545 18.28920 7.87e-08 Zinc-coordinating DNA-binding domains N
chr17 62231938 62234669 RORA Transfac.V$RORA_05 62234530 62234549 12.89090 7.43e-07 Zinc-coordinating DNA-binding domains N
chr17 62231938 62234669 RORA Jolma2013.RORA_DBD 62234530 62234549 13.61620 8.57e-07 Zinc-coordinating DNA-binding domains N
chr17 62235055 62237029 RREB1 Transfac.V$RREB1_01 62236775 62236788 19.01820 3.2e-07 Zinc-coordinating DNA-binding domains Y
chr17 62222475 62224916 RREB1 JASPAR2014.MA0073.1 62222779 62222798 21.25450 6.67e-08 Zinc-coordinating DNA-binding domains Y
chr17 62222475 62224916 RREB1 JASPAR2014.MA0073.1 62222781 62222800 20.34550 1.19e-07 Zinc-coordinating DNA-binding domains Y
chr17 62222475 62224916 RREB1 JASPAR2014.MA0073.1 62222784 62222803 16.75450 7.08e-07 Zinc-coordinating DNA-binding domains Y
chr17 62235055 62237029 RREB1 JASPAR2014.MA0073.1 62236769 62236788 16.70000 7.25e-07 Zinc-coordinating DNA-binding domains Y
chr17 62225182 62226227 RUNX3 Transfac.V$AML2_Q3_01 62226050 62226060 14.97300 4.97e-07 Immunoglobulin fold N
chr17 62231938 62234669 SOX8 Transfac.V$SOX8_07 62232635 62232651 4.68421 6.82e-07 Other all-alpha-helical DNA-binding domains N
chr17 62222475 62224916 SP1 Transfac.V$SP1_Q6_02 62222794 62222810 14.68220 2.47e-07 Zinc-coordinating DNA-binding domains N
chr17 62222475 62224916 SP1 Transfac.V$SP1_Q6_02 62222795 62222811 15.11680 1.23e-07 Zinc-coordinating DNA-binding domains N
chr17 62222475 62224916 SP1 Transfac.V$SP1_Q6_02 62222796 62222812 14.07940 6.07e-07 Zinc-coordinating DNA-binding domains N
chr17 62222475 62224916 SP1 Transfac.V$SP1_Q6_02 62222797 62222813 15.37850 8.07e-08 Zinc-coordinating DNA-binding domains N
chr17 62222475 62224916 SP1 Transfac.V$SP1_Q6_02 62222799 62222815 14.67760 2.49e-07 Zinc-coordinating DNA-binding domains N
chr17 62231938 62234669 SP100 Transfac.V$SP100_03 62232998 62233011 16.15660 1.4e-07 alpha-Helices exposed by beta-structures N
chr17 62231938 62234669 SP100 Transfac.V$SP100_03 62232998 62233011 15.89160 2.31e-07 alpha-Helices exposed by beta-structures N
chr17 62235055 62237029 SPDEF Jolma2013.SPDEF_DBD_3 62236273 62236288 16.77780 9.01e-07 Helix-turn-helix domains N
chr17 62222475 62224916 SRF Transfac.V$SRF_06 62222764 62222780 14.07950 7.59e-07 alpha-Helices exposed by beta-structures N
chr17 62222475 62224916 SRF Uniprobe.UP00077_2 62222764 62222780 14.10170 6.73e-07 alpha-Helices exposed by beta-structures N
chr17 62231938 62234669 TBR1 Jolma2013.TBR1_DBD 62234094 62234103 17.18000 9.1e-07 Immunoglobulin fold N
chr17 62225182 62226227 TEF Transfac.V$TEF_Q6 62225699 62225710 17.69350 3.92e-07 Basic domains N
chr17 62231938 62234669 TFAP2A Transfac.V$TFAP2A_03 62234065 62234075 15.47270 5.19e-07 Basic domains N
chr17 62231938 62234669 TFAP2A Jolma2013.TFAP2A_DBD_2 62234065 62234075 15.39000 5.19e-07 Basic domains N
chr17 62231938 62234669 TFAP2B Transfac.V$TFAP2B_03 62234065 62234075 16.54550 2.54e-07 Basic domains N
chr17 62231938 62234669 TFAP2B Jolma2013.TFAP2B_DBD_2 62234065 62234075 16.48000 2.54e-07 Basic domains N
chr17 62231938 62234669 TFAP2C Transfac.V$TFAP2C_03 62234065 62234075 15.06450 2.54e-07 Basic domains N
chr17 62231938 62234669 TFAP2C Jolma2013.TFAP2C_DBD_2 62234065 62234075 15.69000 2.54e-07 Basic domains N
chr17 62231938 62234669 TFAP2C Jolma2013.TFAP2C_full_3 62234065 62234075 14.99000 2.54e-07 Basic domains N

The Upstream Pathways of TFs Binding to SE



TF Pathway ID Pathway Name Source
BCL6 pathway0000270 BCR NetPath
BCL6 pathway0000271 BCR signaling pathway PID
BCL6 pathway0000608 Direct p53 effectors PID
BCL6 pathway0000827 FoxO family signaling PID
BCL6 pathway0001127 IL4-mediated signaling events PID
BCL6 pathway0002034 Signaling events mediated by HDAC Class II PID
BCL6 pathway0002277 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Reactome
BCL6 pathway0002874 Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016 WikiPathways
CDX1 pathway0001848 Regulation of nuclear beta catenin signaling and target gene transcription PID
CDX2 pathway0001702 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation Reactome
CDX2 pathway0002181 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Reactome
EOMES pathway0000634 Downstream signaling in naïve CD8+ T cells PID
EOMES pathway0001116 IL12-mediated signaling events PID
EOMES pathway0001702 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation Reactome
HNF4A pathway0000825 FOXA2 and FOXA3 transcription factor networks PID
HNF4A pathway0001021 HIF-1-alpha transcription factor network PID
HNF4A pathway0001534 Nuclear Receptor transcription pathway Reactome
HNF4A pathway0001834 Regulation of gene expression in beta cells Reactome
HNF4A pathway0001849 Regulation of nuclear SMAD2/3 signaling PID
HNF4A pathway0002222 TGF_beta_Receptor NetPath
HNF4A pathway0002631 Maturity onset diabetes of the young KEGG
HOXA10 pathway0002035 Signaling events mediated by HDAC Class III PID
NR0B1 pathway0001534 Nuclear Receptor transcription pathway Reactome
NR0B1 pathway0001825 Regulation of Androgen receptor activity PID
NR0B1 pathway0002388 Validated nuclear estrogen receptor alpha network PID
NR0B1 pathway0002389 Validated nuclear estrogen receptor beta network PID
PDX1 pathway0000825 FOXA2 and FOXA3 transcription factor networks PID
PDX1 pathway0001834 Regulation of gene expression in beta cells Reactome
PDX1 pathway0001835 Regulation of gene expression in early pancreatic precursor cells Reactome
PDX1 pathway0002629 Type II diabetes mellitus KEGG
PDX1 pathway0002631 Maturity onset diabetes of the young KEGG
RARA pathway0000061 Activation of anterior HOX genes in hindbrain development during early embryogenesis Reactome
RARA pathway0000842 FSH NetPath
RARA pathway0001126 IL3 NetPath
RARA pathway0001534 Nuclear Receptor transcription pathway Reactome
RARA pathway0001883 Retinoic acid receptors-mediated signaling PID
RARA pathway0001947 RXR and RAR heterodimerization with other nuclear receptor PID
RARA pathway0002028 Signaling by Retinoic Acid Reactome
RARA pathway0002656 Pathways in cancer KEGG
RARA pathway0002668 Acute myeloid leukemia KEGG
RARA pathway0002686 Hs_Tryptophan_metabolism_WP465_85055 WikiPathways
RARB pathway0000061 Activation of anterior HOX genes in hindbrain development during early embryogenesis Reactome
RARB pathway0001534 Nuclear Receptor transcription pathway Reactome
RARB pathway0001883 Retinoic acid receptors-mediated signaling PID
RARB pathway0001947 RXR and RAR heterodimerization with other nuclear receptor PID
RARB pathway0002028 Signaling by Retinoic Acid Reactome
RARB pathway0002656 Pathways in cancer KEGG
RARB pathway0002669 Small cell lung cancer KEGG
RARB pathway0002670 Non-small cell lung cancer KEGG
RARG pathway0000061 Activation of anterior HOX genes in hindbrain development during early embryogenesis Reactome
RARG pathway0001534 Nuclear Receptor transcription pathway Reactome
RARG pathway0001883 Retinoic acid receptors-mediated signaling PID
RARG pathway0001947 RXR and RAR heterodimerization with other nuclear receptor PID
RARG pathway0002028 Signaling by Retinoic Acid Reactome
REST pathway0000986 HDACs deacetylate histones Reactome
REST pathway0002642 Huntington's disease KEGG
REST pathway0002812 Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 WikiPathways
RORA pathway0000316 BMAL1:CLOCK,NPAS2 activates circadian gene expression Reactome
RORA pathway0000430 Circadian Clock Reactome
RORA pathway0001021 HIF-1-alpha transcription factor network PID
RORA pathway0001534 Nuclear Receptor transcription pathway Reactome
RORA pathway0001704 PPARA activates gene expression Reactome
RORA pathway0001940 RORA activates gene expression Reactome
RORA pathway0002700 Hs_Signaling_of_Hepatocyte_Growth_Factor_Receptor_WP313_79946 WikiPathways
RORA pathway0002789 Hs_Complement_and_Coagulation_Cascades_WP558_90196 WikiPathways
RUNX3 pathway0001849 Regulation of nuclear SMAD2/3 signaling PID
RUNX3 pathway0002222 TGF_beta_Receptor NetPath
RUNX3 pathway0002688 Hs_TYROBP_Causal_Network_WP3945_90843 WikiPathways
RUNX3 pathway0002812 Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 WikiPathways
SP1 pathway0000069 Activation of gene expression by SREBF (SREBP) Reactome
SP1 pathway0000176 AndrogenReceptor NetPath
SP1 pathway0000187 AP-1 transcription factor network PID
SP1 pathway0000335 C-MYB transcription factor network PID
SP1 pathway0000608 Direct p53 effectors PID
SP1 pathway0000648 E2F transcription factor network PID
SP1 pathway0000658 EGFR1 NetPath
SP1 pathway0000824 FOXA1 transcription factor network PID
SP1 pathway0000825 FOXA2 and FOXA3 transcription factor networks PID
SP1 pathway0000826 FOXM1 transcription factor network PID
SP1 pathway0001021 HIF-1-alpha transcription factor network PID
SP1 pathway0001022 HIF-2-alpha transcription factor network PID
SP1 pathway0001046 Huntington disease PANTHER
SP1 pathway0001122 IL2 signaling events mediated by STAT5 PID
SP1 pathway0001127 IL4-mediated signaling events PID
SP1 pathway0001264 Leptin NetPath
SP1 pathway0001543 Oncogene Induced Senescence Reactome
SP1 pathway0001582 p73 transcription factor network PID
SP1 pathway0001704 PPARA activates gene expression Reactome
SP1 pathway0001849 Regulation of nuclear SMAD2/3 signaling PID
SP1 pathway0001861 Regulation of Telomerase PID
SP1 pathway0001921 RNA polymerase II transcribes snRNA genes Reactome
SP1 pathway0002069 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Reactome
SP1 pathway0002222 TGF_beta_Receptor NetPath
SP1 pathway0002391 Validated targets of C-MYC transcriptional repression PID
SP1 pathway0002392 Validated transcriptional targets of AP1 family members Fra1 and Fra2 PID
SP1 pathway0002394 Validated transcriptional targets of TAp63 isoforms PID
SP1 pathway0002591 TGF-beta signaling pathway KEGG
SP1 pathway0002642 Huntington's disease KEGG
SP1 pathway0002699 Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 WikiPathways
SP1 pathway0002712 Hs_Leptin_signaling_pathway_WP2034_89856 WikiPathways
SP1 pathway0002718 Hs_Interleukin-11_Signaling_Pathway_WP2332_79525 WikiPathways
SP1 pathway0002731 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 WikiPathways
SP1 pathway0002811 Hs_Estrogen_signaling_pathway_WP712_78491 WikiPathways
SP1 pathway0002812 Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 WikiPathways
SP1 pathway0002853 Hs_TGF-beta_Signaling_Pathway_WP366_90028 WikiPathways
SP1 pathway0002862 Hs_AGE-RAGE_pathway_WP2324_89798 WikiPathways
SP1 pathway0002863 Hs_Androgen_receptor_signaling_pathway_WP138_79958 WikiPathways
SP1 pathway0002866 Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 WikiPathways
SP100 pathway0001181 Interferon gamma signaling Reactome
SP100 pathway0002124 SUMOylation of DNA damage response and repair proteins Reactome
SPDEF pathway0000176 AndrogenReceptor NetPath
SPDEF pathway0001604 PDGF signaling pathway PANTHER
SPDEF pathway0001825 Regulation of Androgen receptor activity PID
SRF pathway0000492 Coregulation of Androgen receptor activity PID
SRF pathway0000692 ErbB1 downstream signaling PID
SRF pathway0001191 Interleukin signaling pathway PANTHER
SRF pathway0001572 p38 MAPK pathway PANTHER
SRF pathway0001574 p38 signaling mediated by MAPKAP kinases PID
SRF pathway0001604 PDGF signaling pathway PANTHER
SRF pathway0001605 PDGFR-alpha signaling pathway PID
SRF pathway0001606 PDGFR-beta signaling pathway PID
SRF pathway0001805 Ras Pathway PANTHER
SRF pathway0001894 RHO GTPases Activate Formins Reactome
SRF pathway0001903 RhoA signaling pathway PID
SRF pathway0002034 Signaling events mediated by HDAC Class II PID
SRF pathway0002340 Trk receptor signaling mediated by the MAPK pathway PID
SRF pathway0002562 MAPK signaling pathway KEGG
SRF pathway0002743 Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 WikiPathways
SRF pathway0002750 Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 WikiPathways
SRF pathway0002826 Hs_Mesodermal_Commitment_Pathway_WP2857_87780 WikiPathways
SRF pathway0002834 Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 WikiPathways
TFAP2A pathway0000377 Caspase Cascade in Apoptosis PID
TFAP2A pathway0002699 Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 WikiPathways
TFAP2A pathway0002747 Hs_Neural_Crest_Differentiation_WP2064_79263 WikiPathways
TFAP2A pathway0002841 Hs_Ectoderm_Differentiation_WP2858_89329 WikiPathways
TFAP2A pathway0002849 Hs_Hypothetical_Craniofacial_Development_Pathway_WP3655_88473 WikiPathways
TFAP2B pathway0002215 TGF-beta receptor signaling PID
TFAP2C pathway0002394 Validated transcriptional targets of TAp63 isoforms PID