General Details

Super-enhancer:SE_00_02600673
Genomic Locus: chr19: 54368531-54371068
Size/Length:2537bp
Conservation:0.0551677
BioSample Type:Tissue
Tissue Type:Muscle of trunk
Sample Name:muscle-of-trunk
Source:Roadmap
Element:1
Rank:673
ChIP Density(Case):12131.6803
ChIP Density(Input):285.4125

Super-enhancer Associated Network


* The complex regulatory networks formed by this SE , SE associated genes , TFs binding to the SE and their upstream pathways can be interactively visualized.


Fimo:
SE-Gene Linking Strategies:
Pathway Enriciment Threshold:
Top Pathway:
 



Super-enhancer Associated Statistics

Associated Gene Details

ROSE Overlap:MYADM
ROSE Proximal:MYADM,NLRP12,CACNG7,PRKCG
ROSE Closest:MYADM
The Closest Active:MYADM

Factors Binding to Super-enhancer




Using these SE element regions to analyze by online tools GREAT *The TFs binding to this SE identified by ChIP-seq.

Chrome Element_Start Element_End TF TF Source TF_Start TF_End TF Class Master TF

Using these SE element regions to analyze by online tools GREAT * The TFs binding to this SE predicted by Motif.

Chrome Element_Start Element_End TF Database TF_Start TF_End Score P_Value TF Class Master TF
chr19 54368531 54371068 BCL6 Transfac.V$BCL6_01 54368576 54368591 12.41410 8.19e-07 Zinc-coordinating DNA-binding domains N
chr19 54368531 54371068 FOXJ3 Transfac.V$FOXJ3_06 54368568 54368584 15.48250 2.93e-07 Helix-turn-helix domains N
chr19 54368531 54371068 FOXJ3 Uniprobe.UP00039_2 54368568 54368584 15.44800 2.77e-07 Helix-turn-helix domains N
chr19 54368531 54371068 FOXK1 Transfac.V$FOXK1_04 54368575 54368589 15.51750 7.5e-07 Helix-turn-helix domains N
chr19 54368531 54371068 FOXK1 Uniprobe.UP00025_2 54368575 54368589 15.51050 7.12e-07 Helix-turn-helix domains N
chr19 54368531 54371068 FOXP1 Transfac.V$FOXP1_01 54368568 54368587 10.10840 1.18e-07 Helix-turn-helix domains N
chr19 54368531 54371068 GC Transfac.V$GC_01 54371002 54371015 15.77460 6.27e-07 UNKNOW N
chr19 54368531 54371068 KLF14 Transfac.V$KLF14_01 54370972 54370985 18.12070 5.34e-07 Zinc-coordinating DNA-binding domains N
chr19 54368531 54371068 KLF14 Jolma2013.KLF14_DBD 54370972 54370985 18.06000 5.34e-07 Zinc-coordinating DNA-binding domains N
chr19 54368531 54371068 KLF16 Transfac.V$KLF16_01 54370974 54370984 16.44830 8.45e-07 Zinc-coordinating DNA-binding domains N
chr19 54368531 54371068 KLF16 Jolma2013.KLF16_DBD 54370974 54370984 16.40000 8.45e-07 Zinc-coordinating DNA-binding domains N
chr19 54368531 54371068 KLF4 Transfac.V$GKLF_02 54369615 54369626 16.27270 6.23e-07 Zinc-coordinating DNA-binding domains Y
chr19 54368531 54371068 PAX4 Transfac.V$PAX4_04 54370312 54370341 17.15690 2.33e-07 Helix-turn-helix domains N
chr19 54368531 54371068 PITX2 Transfac.V$PITX2_Q2 54368708 54368718 16.09090 8.91e-07 Helix-turn-helix domains N
chr19 54368531 54371068 PITX2 Transfac.V$PITX2_Q2 54370183 54370193 16.09090 8.91e-07 Helix-turn-helix domains N
chr19 54368531 54371068 PITX2 Transfac.V$PITX2_Q6 54368709 54368718 15.07070 9.1e-07 Helix-turn-helix domains N
chr19 54368531 54371068 PITX2 Transfac.V$PITX2_Q6 54370184 54370193 15.07070 9.1e-07 Helix-turn-helix domains N
chr19 54368531 54371068 POLR3A Transfac.V$RPC155_01 54370131 54370146 21.19200 2.17e-08 ENCODE_TF N
chr19 54368531 54371068 RFX1 JASPAR2014.MA0509.1 54370782 54370795 17.20690 8.05e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX2 Transfac.V$RFX2_01 54370781 54370796 20.15490 1.35e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX2 Transfac.V$RFX2_01 54370781 54370796 20.05630 1.45e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX2 Transfac.V$RFX2_03 54370781 54370796 19.54220 1.89e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX2 Transfac.V$RFX2_03 54370781 54370796 20.42170 9.57e-08 Helix-turn-helix domains N
chr19 54368531 54371068 RFX2 JASPAR2014.MA0600.1 54370777 54370795 17.70690 5.67e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX2 JASPAR2014.MA0600.1 54370895 54370913 18.70690 2.52e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX2 Jolma2013.RFX2_DBD 54370781 54370796 20.10100 1.37e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX2 Jolma2013.RFX2_DBD 54370781 54370796 20.02020 1.44e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX2 Jolma2013.Rfx2_DBD 54370781 54370796 19.50000 1.89e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX2 Jolma2013.Rfx2_DBD 54370781 54370796 20.39000 9.46e-08 Helix-turn-helix domains N
chr19 54368531 54371068 RFX3 Transfac.V$RFX3_06 54370781 54370796 19.54550 1.5e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX3 Transfac.V$RFX3_06 54370781 54370796 19.80300 1.2e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX3 Transfac.V$RFX3_08 54370781 54370796 20.45160 9.16e-08 Helix-turn-helix domains N
chr19 54368531 54371068 RFX3 Transfac.V$RFX3_08 54370781 54370796 18.62900 2.29e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX3 Jolma2013.RFX3_DBD 54370781 54370796 19.49000 1.52e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX3 Jolma2013.RFX3_DBD 54370781 54370796 19.75000 1.22e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX3 Jolma2013.Rfx3_DBD 54370781 54370796 20.41410 9.17e-08 Helix-turn-helix domains N
chr19 54368531 54371068 RFX3 Jolma2013.Rfx3_DBD 54370781 54370796 18.59600 2.37e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX4 Transfac.V$RFX4_05 54370781 54370796 19.21210 1.55e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX4 Transfac.V$RFX4_05 54370781 54370796 17.51520 6.89e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX4 Jolma2013.RFX4_DBD 54370781 54370796 19.17000 1.56e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX4 Jolma2013.RFX4_DBD 54370781 54370796 17.46000 7.05e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX5 Transfac.V$RFX5_01 54370781 54370796 19.74140 1.34e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX5 Transfac.V$RFX5_01 54370781 54370796 20.01720 1.13e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX5 Transfac.V$RFX5_02 54370781 54370796 17.05170 6.35e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX5 Transfac.V$RFX5_02 54370781 54370796 21.50000 3.92e-08 Helix-turn-helix domains N
chr19 54368531 54371068 RFX5 Jolma2013.RFX5_DBD 54370781 54370796 19.72730 1.35e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX5 Jolma2013.RFX5_DBD 54370781 54370796 19.98990 1.14e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX5 Jolma2013.RFX5_DBD_2 54370781 54370796 17.07000 6.57e-07 Helix-turn-helix domains N
chr19 54368531 54371068 RFX5 Jolma2013.RFX5_DBD_2 54370781 54370796 21.48000 3.97e-08 Helix-turn-helix domains N
chr19 54368531 54371068 RREB1 Transfac.V$RREB1_01 54370323 54370336 19.30910 2.1e-07 Zinc-coordinating DNA-binding domains Y
chr19 54368531 54371068 RREB1 JASPAR2014.MA0073.1 54370323 54370342 22.45450 2.74e-08 Zinc-coordinating DNA-binding domains Y
chr19 54368531 54371068 SP1 Transfac.V$SP1_05 54370974 54370984 15.32690 2.77e-07 Zinc-coordinating DNA-binding domains N
chr19 54368531 54371068 SP1 Jolma2013.SP1_DBD 54370974 54370984 15.27000 2.77e-07 Zinc-coordinating DNA-binding domains N
chr19 54368531 54371068 SP4 Transfac.V$SP4_Q5 54371003 54371013 17.39000 6.06e-07 Zinc-coordinating DNA-binding domains N
chr19 54368531 54371068 SP8 Transfac.V$SP8_01 54370973 54370984 16.35060 7.56e-07 Zinc-coordinating DNA-binding domains N
chr19 54368531 54371068 SP8 Jolma2013.SP8_DBD 54370973 54370984 16.30000 8.85e-07 Zinc-coordinating DNA-binding domains N
chr19 54368531 54371068 TCF3 Transfac.V$TCF3_06 54370028 54370037 13.78850 9.51e-07 Basic domains N
chr19 54368531 54371068 TCF3 Jolma2013.TCF3_DBD 54370028 54370037 13.74750 9.51e-07 Basic domains N
chr19 54368531 54371068 TFAP2B Jolma2013.TFAP2B_DBD 54369840 54369851 15.23000 9.41e-07 Basic domains N
chr19 54368531 54371068 TFAP2C Transfac.V$TFAP2C_01 54369840 54369851 14.92540 2.65e-07 Basic domains N
chr19 54368531 54371068 TFAP2C Jolma2013.TFAP2C_DBD 54369840 54369851 15.14290 9.38e-07 Basic domains N
chr19 54368531 54371068 TFAP2C Jolma2013.TFAP2C_full 54369840 54369851 14.87130 2.65e-07 Basic domains N
chr19 54368531 54371068 ZFX Transfac.V$ZFX_01 54369637 54369652 16.53030 7.45e-07 Zinc-coordinating DNA-binding domains N
chr19 54368531 54371068 ZFX JASPAR2014.MA0146.2 54369640 54369653 16.37880 5.73e-07 Zinc-coordinating DNA-binding domains N
chr19 54368531 54371068 ZFX JASPAR2014.MA0146.2 54370206 54370219 16.86360 2.19e-07 Zinc-coordinating DNA-binding domains N
chr19 54368531 54371068 ZNF263 JASPAR2014.MA0528.1 54370680 54370700 18.58000 2.47e-07 Zinc-coordinating DNA-binding domains N

The Upstream Pathways of TFs Binding to SE



TF Pathway ID Pathway Name Source
BCL6 pathway0000270 BCR NetPath
BCL6 pathway0000271 BCR signaling pathway PID
BCL6 pathway0000608 Direct p53 effectors PID
BCL6 pathway0000827 FoxO family signaling PID
BCL6 pathway0001127 IL4-mediated signaling events PID
BCL6 pathway0002034 Signaling events mediated by HDAC Class II PID
BCL6 pathway0002277 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Reactome
BCL6 pathway0002874 Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016 WikiPathways
GC pathway0002430 Vitamin D (calciferol) metabolism Reactome
GC pathway0002431 Vitamin D metabolism and pathway PANTHER
KLF4 pathway0001848 Regulation of nuclear beta catenin signaling and target gene transcription PID
KLF4 pathway0002180 Synthesis, secretion, and deacylation of Ghrelin Reactome
KLF4 pathway0002301 Transcriptional regulation of pluripotent stem cells Reactome
KLF4 pathway0002302 Transcriptional regulation of white adipocyte differentiation Reactome
KLF4 pathway0002726 Hs_Role_of_Osx_and_miRNAs_in_tooth_development_WP3971_91525 WikiPathways
KLF4 pathway0002755 Hs_White_fat_cell_differentiation_WP3946_90940 WikiPathways
KLF4 pathway0002826 Hs_Mesodermal_Commitment_Pathway_WP2857_87780 WikiPathways
PAX4 pathway0001836 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells Reactome
PAX4 pathway0002631 Maturity onset diabetes of the young KEGG
PITX2 pathway0001848 Regulation of nuclear beta catenin signaling and target gene transcription PID
PITX2 pathway0002591 TGF-beta signaling pathway KEGG
PITX2 pathway0002768 Hs_Heart_Development_WP1591_90186 WikiPathways
PITX2 pathway0002771 Hs_BMP_Signaling_Pathway_in_Eyelid_Development_WP3927_90735 WikiPathways
POLR3A pathway0000532 Cytosolic sensors of pathogen-associated DNA Reactome
POLR3A pathway0001926 RNA Polymerase III Abortive And Retractive Initiation Reactome
POLR3A pathway0001927 RNA Polymerase III Chain Elongation Reactome
POLR3A pathway0001928 RNA Polymerase III Transcription Initiation From Type 1 Promoter Reactome
POLR3A pathway0001929 RNA Polymerase III Transcription Initiation From Type 2 Promoter Reactome
POLR3A pathway0001930 RNA Polymerase III Transcription Initiation From Type 3 Promoter Reactome
POLR3A pathway0001931 RNA Polymerase III Transcription Termination Reactome
POLR3A pathway0002492 Purine metabolism KEGG
POLR3A pathway0002494 Pyrimidine metabolism KEGG
POLR3A pathway0002605 Cytosolic DNA-sensing pathway KEGG
RFX5 pathway0002601 Antigen processing and presentation KEGG
SP1 pathway0000069 Activation of gene expression by SREBF (SREBP) Reactome
SP1 pathway0000176 AndrogenReceptor NetPath
SP1 pathway0000187 AP-1 transcription factor network PID
SP1 pathway0000335 C-MYB transcription factor network PID
SP1 pathway0000608 Direct p53 effectors PID
SP1 pathway0000648 E2F transcription factor network PID
SP1 pathway0000658 EGFR1 NetPath
SP1 pathway0000824 FOXA1 transcription factor network PID
SP1 pathway0000825 FOXA2 and FOXA3 transcription factor networks PID
SP1 pathway0000826 FOXM1 transcription factor network PID
SP1 pathway0001021 HIF-1-alpha transcription factor network PID
SP1 pathway0001022 HIF-2-alpha transcription factor network PID
SP1 pathway0001046 Huntington disease PANTHER
SP1 pathway0001122 IL2 signaling events mediated by STAT5 PID
SP1 pathway0001127 IL4-mediated signaling events PID
SP1 pathway0001264 Leptin NetPath
SP1 pathway0001543 Oncogene Induced Senescence Reactome
SP1 pathway0001582 p73 transcription factor network PID
SP1 pathway0001704 PPARA activates gene expression Reactome
SP1 pathway0001849 Regulation of nuclear SMAD2/3 signaling PID
SP1 pathway0001861 Regulation of Telomerase PID
SP1 pathway0001921 RNA polymerase II transcribes snRNA genes Reactome
SP1 pathway0002069 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Reactome
SP1 pathway0002222 TGF_beta_Receptor NetPath
SP1 pathway0002391 Validated targets of C-MYC transcriptional repression PID
SP1 pathway0002392 Validated transcriptional targets of AP1 family members Fra1 and Fra2 PID
SP1 pathway0002394 Validated transcriptional targets of TAp63 isoforms PID
SP1 pathway0002591 TGF-beta signaling pathway KEGG
SP1 pathway0002642 Huntington's disease KEGG
SP1 pathway0002699 Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 WikiPathways
SP1 pathway0002712 Hs_Leptin_signaling_pathway_WP2034_89856 WikiPathways
SP1 pathway0002718 Hs_Interleukin-11_Signaling_Pathway_WP2332_79525 WikiPathways
SP1 pathway0002731 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 WikiPathways
SP1 pathway0002811 Hs_Estrogen_signaling_pathway_WP712_78491 WikiPathways
SP1 pathway0002812 Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 WikiPathways
SP1 pathway0002853 Hs_TGF-beta_Signaling_Pathway_WP366_90028 WikiPathways
SP1 pathway0002862 Hs_AGE-RAGE_pathway_WP2324_89798 WikiPathways
SP1 pathway0002863 Hs_Androgen_receptor_signaling_pathway_WP138_79958 WikiPathways
SP1 pathway0002866 Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 WikiPathways
TCF3 pathway0000393 CDO in myogenesis Reactome
TCF3 pathway0001078 ID NetPath
TCF3 pathway0001516 Notch-mediated HES/HEY network PID
TCF3 pathway0001517 Notch NetPath
TCF3 pathway0001574 p38 signaling mediated by MAPKAP kinases PID
TCF3 pathway0001849 Regulation of nuclear SMAD2/3 signaling PID
TCF3 pathway0002439 Wnt NetPath
TCF3 pathway0002841 Hs_Ectoderm_Differentiation_WP2858_89329 WikiPathways
TFAP2B pathway0002215 TGF-beta receptor signaling PID
TFAP2C pathway0002394 Validated transcriptional targets of TAp63 isoforms PID
ZNF263 pathway0000905 Generic Transcription Pathway Reactome