General Details

Super-enhancer:SE_00_02600576
Genomic Locus: chr14: 50086293-50102759
Size/Length:16466bp
Conservation:0.109905
BioSample Type:Tissue
Tissue Type:Muscle of trunk
Sample Name:muscle-of-trunk
Source:Roadmap
Element:2
Rank:576
ChIP Density(Case):14075.1368
ChIP Density(Input):1197.0782

Super-enhancer Associated Network


* The complex regulatory networks formed by this SE , SE associated genes , TFs binding to the SE and their upstream pathways can be interactively visualized.


Fimo:
SE-Gene Linking Strategies:
Pathway Enriciment Threshold:
Top Pathway:
 



Super-enhancer Associated Statistics

Associated Gene Details

ROSE Overlap:MGAT2,RPL36AL,C14orf104
ROSE Proximal:PPIL5,RPS29,C14orf104
ROSE Closest:MGAT2
The Closest Active:MGAT2

Factors Binding to Super-enhancer




Using these SE element regions to analyze by online tools GREAT *The TFs binding to this SE identified by ChIP-seq.

Chrome Element_Start Element_End TF TF Source TF_Start TF_End TF Class Master TF

Using these SE element regions to analyze by online tools GREAT * The TFs binding to this SE predicted by Motif.

Chrome Element_Start Element_End TF Database TF_Start TF_End Score P_Value TF Class Master TF
chr14 50086293 50088416 ASCL2 Transfac.V$ASCL2_05 50087934 50087943 16.50700 9.94e-07 Basic domains N
chr14 50086293 50088416 ASCL2 Transfac.V$ASCL2_05 50087934 50087943 16.50700 9.94e-07 Basic domains N
chr14 50086293 50088416 ASCL2 Jolma2013.Ascl2_DBD 50087934 50087943 16.45450 9.94e-07 Basic domains N
chr14 50086293 50088416 ASCL2 Jolma2013.Ascl2_DBD 50087934 50087943 16.45450 9.94e-07 Basic domains N
chr14 50086293 50088416 FOXD3 Transfac.V$FOXD3_01 50086386 50086397 16.88890 2.04e-07 Helix-turn-helix domains N
chr14 50086293 50088416 FOXD3 JASPAR2014.MA0041.1 50086386 50086397 17.67780 1.54e-07 Helix-turn-helix domains N
chr14 50099780 50102759 FOXJ3 Transfac.V$FOXJ3_06 50102433 50102449 15.08390 6.59e-07 Helix-turn-helix domains N
chr14 50099780 50102759 FOXJ3 Uniprobe.UP00039_2 50102433 50102449 15.01600 6.71e-07 Helix-turn-helix domains N
chr14 50099780 50102759 FOXL1 Transfac.V$FOXL1_02 50102423 50102438 15.29660 8.26e-07 Helix-turn-helix domains N
chr14 50099780 50102759 FOXL1 Transfac.V$FOXL1_02 50102428 50102443 17.82760 1.16e-08 Helix-turn-helix domains N
chr14 50099780 50102759 FOXL1 Transfac.V$FOXL1_02 50102433 50102448 17.82760 1.16e-08 Helix-turn-helix domains N
chr14 50099780 50102759 FOXL1 Uniprobe.UP00061_2 50102423 50102438 15.27590 7.95e-07 Helix-turn-helix domains N
chr14 50099780 50102759 FOXL1 Uniprobe.UP00061_2 50102428 50102443 17.77240 1.12e-08 Helix-turn-helix domains N
chr14 50099780 50102759 FOXL1 Uniprobe.UP00061_2 50102433 50102448 17.77240 1.12e-08 Helix-turn-helix domains N
chr14 50099780 50102759 FOXP1 JASPAR2014.MA0481.1 50102440 50102454 16.81690 9.99e-07 Helix-turn-helix domains N
chr14 50086293 50088416 FOXQ1 Transfac.V$HFH1_01 50086386 50086397 17.48480 7.35e-07 Helix-turn-helix domains N
chr14 50099780 50102759 GLI1 Transfac.V$GLI1_01 50100330 50100340 17.31000 7.73e-07 Zinc-coordinating DNA-binding domains N
chr14 50099780 50102759 GLI2 Transfac.V$GLI2_01 50100330 50100340 17.58590 7.73e-07 Zinc-coordinating DNA-binding domains N
chr14 50099780 50102759 GLI2 Transfac.V$GLI2_03 50100330 50100343 16.62340 5.73e-07 Zinc-coordinating DNA-binding domains N
chr14 50099780 50102759 GLI2 Jolma2013.GLI2_DBD 50100330 50100343 16.58000 5.57e-07 Zinc-coordinating DNA-binding domains N
chr14 50086293 50088416 HIC1 Transfac.V$HIC1_03 50088126 50088143 15.07230 8.35e-07 Zinc-coordinating DNA-binding domains Y
chr14 50086293 50088416 MYOD1 JASPAR2014.MA0499.1 50087934 50087946 15.48980 8.8e-07 Basic domains Y
chr14 50099780 50102759 PITX2 Transfac.V$PITX2_Q2 50099903 50099913 16.09090 8.91e-07 Helix-turn-helix domains N
chr14 50099780 50102759 PITX2 Transfac.V$PITX2_Q2 50102094 50102104 16.09090 8.91e-07 Helix-turn-helix domains N
chr14 50099780 50102759 PITX2 Transfac.V$PITX2_Q6 50099904 50099913 15.07070 9.1e-07 Helix-turn-helix domains N
chr14 50099780 50102759 PITX2 Transfac.V$PITX2_Q6 50102094 50102103 15.07070 9.1e-07 Helix-turn-helix domains N
chr14 50099780 50102759 POLR3A Transfac.V$RPC155_01 50099853 50099868 19.25600 1.54e-07 ENCODE_TF N
chr14 50099780 50102759 POLR3A Transfac.V$RPC155_01 50102139 50102154 20.30400 5.58e-08 ENCODE_TF N
chr14 50099780 50102759 POLR3A Transfac.V$RPC155_01 50102655 50102670 20.30400 5.58e-08 ENCODE_TF N
chr14 50086293 50088416 POU5F1 Transfac.V$OCT4_01 50086512 50086526 17.63640 5.09e-07 Helix-turn-helix domains N
chr14 50099780 50102759 POU5F1 Transfac.V$POU5F1_01 50099806 50099815 12.25810 8.34e-07 Helix-turn-helix domains N
chr14 50086293 50088416 REST Transfac.V$REST_Q5 50087689 50087701 18.97590 1.59e-08 Zinc-coordinating DNA-binding domains N
chr14 50099780 50102759 SP2 JASPAR2014.MA0516.1 50100699 50100713 17.53450 2.48e-07 Zinc-coordinating DNA-binding domains N
chr14 50099780 50102759 TFAP4 Transfac.V$AP4_Q6_02 50100584 50100596 15.66000 7.09e-08 Basic domains Y
chr14 50086293 50088416 VDR Transfac.V$VDR_Q3 50086895 50086909 17.29200 5.3e-08 Zinc-coordinating DNA-binding domains N
chr14 50086293 50088416 XBP1 Transfac.V$XBP1_01 50087066 50087082 17.58890 2.94e-07 Basic domains N
chr14 50086293 50088416 XBP1 Transfac.V$XBP1_05 50087068 50087081 19.40380 9.82e-08 Basic domains N
chr14 50086293 50088416 XBP1 Jolma2013.XBP1_DBD_2 50087068 50087081 19.34340 9.82e-08 Basic domains N
chr14 50086293 50088416 ZNF263 JASPAR2014.MA0528.1 50086900 50086920 18.18000 3.43e-07 Zinc-coordinating DNA-binding domains N
chr14 50086293 50088416 ZNF263 JASPAR2014.MA0528.1 50086903 50086923 19.42000 1.22e-07 Zinc-coordinating DNA-binding domains N
chr14 50099780 50102759 ZNF350 Transfac.V$ZBRK1_01 50100547 50100561 17.76770 8.44e-07 Zinc-coordinating DNA-binding domains N

The Upstream Pathways of TFs Binding to SE



TF Pathway ID Pathway Name Source
FOXD3 pathway0001701 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Reactome
FOXD3 pathway0002747 Hs_Neural_Crest_Differentiation_WP2064_79263 WikiPathways
GLI1 pathway0000428 Ci/Gli processing signaling ( Hedgehog signaling pathway ) INOH
GLI1 pathway0000578 Degradation of GLI1 by the proteasome Reactome
GLI1 pathway0000756 FAS signaling pathway PANTHER
GLI1 pathway0000907 GLI proteins bind promoters of Hh responsive genes to promote transcription Reactome
GLI1 pathway0000992 Hedgehog 'off' state Reactome
GLI1 pathway0000993 Hedgehog 'on' state Reactome
GLI1 pathway0000994 Hedgehog NetPath
GLI1 pathway0000996 Hedgehog signaling events mediated by Gli proteins PID
GLI1 pathway0000997 Hedgehog signaling pathway PANTHER
GLI1 pathway0002475 Signaling without Hh ( Hedgehog signaling pathway ) INOH
GLI1 pathway0002590 Hedgehog signaling pathway KEGG
GLI1 pathway0002656 Pathways in cancer KEGG
GLI1 pathway0002664 Basal cell carcinoma KEGG
GLI1 pathway0002746 Hs_Dopaminergic_Neurogenesis_WP2855_87239 WikiPathways
GLI2 pathway0000428 Ci/Gli processing signaling ( Hedgehog signaling pathway ) INOH
GLI2 pathway0000579 Degradation of GLI2 by the proteasome Reactome
GLI2 pathway0000907 GLI proteins bind promoters of Hh responsive genes to promote transcription Reactome
GLI2 pathway0000992 Hedgehog 'off' state Reactome
GLI2 pathway0000993 Hedgehog 'on' state Reactome
GLI2 pathway0000994 Hedgehog NetPath
GLI2 pathway0000996 Hedgehog signaling events mediated by Gli proteins PID
GLI2 pathway0002041 Signaling events mediated by the Hedgehog family PID
GLI2 pathway0002475 Signaling without Hh ( Hedgehog signaling pathway ) INOH
GLI2 pathway0002590 Hedgehog signaling pathway KEGG
GLI2 pathway0002656 Pathways in cancer KEGG
GLI2 pathway0002664 Basal cell carcinoma KEGG
HIC1 pathway0000608 Direct p53 effectors PID
HIC1 pathway0000648 E2F transcription factor network PID
MYOD1 pathway0000335 C-MYB transcription factor network PID
MYOD1 pathway0000393 CDO in myogenesis Reactome
MYOD1 pathway0001078 ID NetPath
MYOD1 pathway0001516 Notch-mediated HES/HEY network PID
MYOD1 pathway0001849 Regulation of nuclear SMAD2/3 signaling PID
MYOD1 pathway0001857 Regulation of retinoblastoma protein PID
MYOD1 pathway0002035 Signaling events mediated by HDAC Class III PID
MYOD1 pathway0002878 Hs_ID_signaling_pathway_WP53_67360 WikiPathways
PITX2 pathway0001848 Regulation of nuclear beta catenin signaling and target gene transcription PID
PITX2 pathway0002591 TGF-beta signaling pathway KEGG
PITX2 pathway0002768 Hs_Heart_Development_WP1591_90186 WikiPathways
PITX2 pathway0002771 Hs_BMP_Signaling_Pathway_in_Eyelid_Development_WP3927_90735 WikiPathways
POLR3A pathway0000532 Cytosolic sensors of pathogen-associated DNA Reactome
POLR3A pathway0001926 RNA Polymerase III Abortive And Retractive Initiation Reactome
POLR3A pathway0001927 RNA Polymerase III Chain Elongation Reactome
POLR3A pathway0001928 RNA Polymerase III Transcription Initiation From Type 1 Promoter Reactome
POLR3A pathway0001929 RNA Polymerase III Transcription Initiation From Type 2 Promoter Reactome
POLR3A pathway0001930 RNA Polymerase III Transcription Initiation From Type 3 Promoter Reactome
POLR3A pathway0001931 RNA Polymerase III Transcription Termination Reactome
POLR3A pathway0002492 Purine metabolism KEGG
POLR3A pathway0002494 Pyrimidine metabolism KEGG
POLR3A pathway0002605 Cytosolic DNA-sensing pathway KEGG
POU5F1 pathway0001022 HIF-2-alpha transcription factor network PID
POU5F1 pathway0001701 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Reactome
POU5F1 pathway0001702 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation Reactome
POU5F1 pathway0002301 Transcriptional regulation of pluripotent stem cells Reactome
POU5F1 pathway0002740 Hs_Endoderm_Differentiation_WP2853_88152 WikiPathways
POU5F1 pathway0002821 Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291 WikiPathways
REST pathway0000986 HDACs deacetylate histones Reactome
REST pathway0002642 Huntington's disease KEGG
REST pathway0002812 Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 WikiPathways
VDR pathway0000608 Direct p53 effectors PID
VDR pathway0001534 Nuclear Receptor transcription pathway Reactome
VDR pathway0001849 Regulation of nuclear SMAD2/3 signaling PID
VDR pathway0001883 Retinoic acid receptors-mediated signaling PID
VDR pathway0001947 RXR and RAR heterodimerization with other nuclear receptor PID
VDR pathway0002222 TGF_beta_Receptor NetPath
VDR pathway0002393 Validated transcriptional targets of deltaNp63 isoforms PID
VDR pathway0002394 Validated transcriptional targets of TAp63 isoforms PID
VDR pathway0002431 Vitamin D metabolism and pathway PANTHER
VDR pathway0002685 Hs_Drug_Induction_of_Bile_Acid_Pathway_WP2289_88593 WikiPathways
XBP1 pathway0000231 ATF6-alpha activates chaperone genes Reactome
XBP1 pathway0000824 FOXA1 transcription factor network PID
XBP1 pathway0002388 Validated nuclear estrogen receptor alpha network PID
XBP1 pathway0002456 XBP1(S) activates chaperone genes Reactome
XBP1 pathway0002579 Protein processing in endoplasmic reticulum KEGG