General Details

Super-enhancer:SE_00_02600561
Genomic Locus: chr6: 24719242-24722629
Size/Length:3387bp
Conservation:0.226492
BioSample Type:Tissue
Tissue Type:Muscle of trunk
Sample Name:muscle-of-trunk
Source:Roadmap
Element:1
Rank:561
ChIP Density(Case):13691.9475
ChIP Density(Input):625.2402

Super-enhancer Associated Network


* The complex regulatory networks formed by this SE , SE associated genes , TFs binding to the SE and their upstream pathways can be interactively visualized.


Fimo:
SE-Gene Linking Strategies:
Pathway Enriciment Threshold:
Top Pathway:
 



Super-enhancer Associated Statistics

Associated Gene Details

ROSE Overlap:C6orf62
ROSE Proximal:.
ROSE Closest:C6orf62
The Closest Active:C6ORF62

Factors Binding to Super-enhancer




Using these SE element regions to analyze by online tools GREAT *The TFs binding to this SE identified by ChIP-seq.

Chrome Element_Start Element_End TF TF Source TF_Start TF_End TF Class Master TF

Using these SE element regions to analyze by online tools GREAT * The TFs binding to this SE predicted by Motif.

Chrome Element_Start Element_End TF Database TF_Start TF_End Score P_Value TF Class Master TF
chr6 24719242 24722629 ASCL2 Transfac.V$ASCL2_04 24720380 24720395 12.29670 9.67e-07 Basic domains N
chr6 24719242 24722629 ASCL2 Uniprobe.UP00099_2 24720380 24720395 12.23770 9.54e-07 Basic domains N
chr6 24719242 24722629 EGR1 JASPAR2014.MA0162.2 24720158 24720171 16.75000 8.18e-07 Zinc-coordinating DNA-binding domains N
chr6 24719242 24722629 ELF3 Transfac.V$ELF4_04 24719378 24719394 14.31840 5.34e-07 Helix-turn-helix domains N
chr6 24719242 24722629 ELF3 Uniprobe.UP00407_2 24719378 24719394 14.35750 4.67e-07 Helix-turn-helix domains N
chr6 24719242 24722629 FOXP1 Transfac.V$FOXP1_01 24719383 24719402 5.19277 4.84e-07 Helix-turn-helix domains N
chr6 24719242 24722629 IRF3 Transfac.V$IRF3_07 24721660 24721680 16.67470 4.2e-07 Helix-turn-helix domains N
chr6 24719242 24722629 IRF3 Jolma2013.IRF3_full 24721660 24721680 16.70710 4.56e-07 Helix-turn-helix domains N
chr6 24719242 24722629 MAX Transfac.V$MAX_Q6 24721851 24721862 16.08080 8.26e-07 Basic domains N
chr6 24719242 24722629 MZF1 JASPAR2014.MA0057.1 24720888 24720897 13.71000 9.94e-07 Zinc-coordinating DNA-binding domains N
chr6 24719242 24722629 NFKB2 Transfac.V$NFKB2_01 24720400 24720412 17.47890 9.14e-07 Immunoglobulin fold N
chr6 24719242 24722629 NFKB2 Transfac.V$NFKB2_01 24720400 24720412 17.69010 7.55e-07 Immunoglobulin fold N
chr6 24719242 24722629 NFKB2 Jolma2013.NFKB2_DBD 24720400 24720412 17.39000 9.29e-07 Immunoglobulin fold N
chr6 24719242 24722629 NFKB2 Jolma2013.NFKB2_DBD 24720400 24720412 17.61000 7.55e-07 Immunoglobulin fold N
chr6 24719242 24722629 NKX3-1 Transfac.V$NKX3A_02 24722149 24722165 16.49500 9.43e-07 Helix-turn-helix domains N
chr6 24719242 24722629 NKX3-1 Homeodomain.UP00017_1 24722149 24722165 16.51790 9.28e-07 Helix-turn-helix domains N
chr6 24719242 24722629 NKX3-1 Uniprobe.UP00017_3 24722149 24722165 16.51790 9.28e-07 Helix-turn-helix domains N
chr6 24719242 24722629 PAX4 JASPAR2014.MA0068.1 24721199 24721228 16.23000 6.45e-07 Helix-turn-helix domains N
chr6 24719242 24722629 POLR3A Transfac.V$RPC155_01 24722606 24722621 23.71200 2.42e-10 ENCODE_TF N
chr6 24719242 24722629 REL Transfac.V$CREL_01 24720402 24720411 14.81000 9.94e-07 TcoF-DB_TF N
chr6 24719242 24722629 REL JASPAR2014.MA0101.1 24720402 24720411 14.72000 9.94e-07 TcoF-DB_TF N
chr6 24719242 24722629 SMAD3 Transfac.V$SMAD4_04 24721407 24721423 15.22620 7.76e-07 beta-Hairpin exposed by an alpha/beta-scaffold N
chr6 24719242 24722629 SMAD3 Uniprobe.UP00000_2 24721407 24721423 15.13490 7.88e-07 beta-Hairpin exposed by an alpha/beta-scaffold N
chr6 24719242 24722629 SP4 Transfac.V$SP4_Q5 24721471 24721481 17.39000 6.06e-07 Zinc-coordinating DNA-binding domains N
chr6 24719242 24722629 SPDEF Jolma2013.SPDEF_DBD_2 24720267 24720281 17.57000 6.53e-07 Helix-turn-helix domains N
chr6 24719242 24722629 SRF Transfac.V$SRF_06 24719381 24719397 14.24430 5.96e-07 alpha-Helices exposed by beta-structures N
chr6 24719242 24722629 SRF Transfac.V$SRF_06 24719382 24719398 13.89200 9.97e-07 alpha-Helices exposed by beta-structures N
chr6 24719242 24722629 SRF Uniprobe.UP00077_2 24719381 24719397 14.15820 6.21e-07 alpha-Helices exposed by beta-structures N
chr6 24719242 24722629 TFAP2A Transfac.V$AP2_Q3 24720474 24720489 16.21000 2.53e-07 Basic domains N
chr6 24719242 24722629 TFAP2A Transfac.V$AP2_Q6_01 24720479 24720491 14.67000 7.08e-07 Basic domains N

The Upstream Pathways of TFs Binding to SE



TF Pathway ID Pathway Name Source
EGR1 pathway0000187 AP-1 transcription factor network PID
EGR1 pathway0000343 Calcineurin-regulated NFAT-dependent transcription in lymphocytes PID
EGR1 pathway0000634 Downstream signaling in naïve CD8+ T cells PID
EGR1 pathway0000692 ErbB1 downstream signaling PID
EGR1 pathway0000916 Glucocorticoid receptor regulatory network PID
EGR1 pathway0001180 Interferon alpha/beta signaling Reactome
EGR1 pathway0001825 Regulation of Androgen receptor activity PID
EGR1 pathway0002036 Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) PID
EGR1 pathway0002037 Signaling events mediated by PRL PID
EGR1 pathway0002199 TCR NetPath
EGR1 pathway0002339 Trk receptor signaling mediated by PI3K and PLC-gamma PID
EGR1 pathway0002340 Trk receptor signaling mediated by the MAPK pathway PID
EGR1 pathway0002643 Prion diseases KEGG
EGR1 pathway0002707 Hs_Thyroid_Stimulating_Hormone_(TSH)_signaling_pathway_WP2032_89823 WikiPathways
EGR1 pathway0002750 Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 WikiPathways
EGR1 pathway0002760 Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 WikiPathways
ELF3 pathway0000658 EGFR1 NetPath
ELF3 pathway0001604 PDGF signaling pathway PANTHER
IRF3 pathway0000070 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Reactome
IRF3 pathway0000747 Factors involved in megakaryocyte development and platelet production Reactome
IRF3 pathway0001180 Interferon alpha/beta signaling Reactome
IRF3 pathway0001181 Interferon gamma signaling Reactome
IRF3 pathway0001212 IRF3-mediated induction of type I IFN Reactome
IRF3 pathway0001213 IRF3 mediated activation of type 1 IFN Reactome
IRF3 pathway0001219 ISG15 antiviral mechanism Reactome
IRF3 pathway0001297 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Reactome
IRF3 pathway0001469 Negative regulators of RIG-I/MDA5 signaling Reactome
IRF3 pathway0001843 Regulation of innate immune responses to cytosolic DNA Reactome
IRF3 pathway0002264 Toll receptor signaling pathway PANTHER
IRF3 pathway0002278 TRAF3-dependent IRF activation pathway Reactome
IRF3 pathway0002282 TRAF6 mediated IRF7 activation Reactome
IRF3 pathway0002602 Toll-like receptor signaling pathway KEGG
IRF3 pathway0002604 RIG-I-like receptor signaling pathway KEGG
IRF3 pathway0002605 Cytosolic DNA-sensing pathway KEGG
IRF3 pathway0002655 Hepatitis C KEGG
IRF3 pathway0002782 Hs_p38_MAPK_Signaling_Pathway_WP400_72084 WikiPathways
IRF3 pathway0002789 Hs_Complement_and_Coagulation_Cascades_WP558_90196 WikiPathways
IRF3 pathway0002824 Hs_RIG-I-like_Receptor_Signaling_WP3865_88186 WikiPathways
IRF3 pathway0002845 Hs_TLR4_Signaling_and_Tolerance_WP3851_90114 WikiPathways
MAX pathway0000336 C-MYC pathway PID
MAX pathway0000515 Cyclin A:Cdk2-associated events at S phase entry Reactome
MAX pathway0000518 Cyclin E associated events during G1/S transition Reactome
MAX pathway0001560 Oxidative stress response PANTHER
MAX pathway0001849 Regulation of nuclear SMAD2/3 signaling PID
MAX pathway0001861 Regulation of Telomerase PID
MAX pathway0002033 Signaling events mediated by HDAC Class I PID
MAX pathway0002390 Validated targets of C-MYC transcriptional activation PID
MAX pathway0002391 Validated targets of C-MYC transcriptional repression PID
MAX pathway0002562 MAPK signaling pathway KEGG
MAX pathway0002656 Pathways in cancer KEGG
MAX pathway0002669 Small cell lung cancer KEGG
MAX pathway0002731 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 WikiPathways
MAX pathway0002757 Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 WikiPathways
MAX pathway0002877 Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900 WikiPathways
NFKB2 pathway0000151 Alternative NF-kappaB pathway PID
NFKB2 pathway0000196 Apoptosis signaling pathway PANTHER
NFKB2 pathway0000552 Dectin-1 mediated noncanonical NF-kB signaling Reactome
NFKB2 pathway0000590 DEx/H-box helicases activate type I IFN and inflammatory cytokines production Reactome
NFKB2 pathway0001089 IkBA variant leads to EDA-ID Reactome
NFKB2 pathway0001090 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) Reactome
NFKB2 pathway0001116 IL12-mediated signaling events PID
NFKB2 pathway0001147 Inflammation mediated by chemokine and cytokine signaling pathway PANTHER
NFKB2 pathway0001182 Interleukin-1 processing Reactome
NFKB2 pathway0001194 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine SMPDB
NFKB2 pathway0001195 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine SMPDB
NFKB2 pathway0001497 NIK-->noncanonical NF-kB signaling Reactome
NFKB2 pathway0001799 RANKL NetPath
NFKB2 pathway0001908 RIP-mediated NFkB activation via ZBP1 Reactome
NFKB2 pathway0002189 TAK1 activates NFkB by phosphorylation and activation of IKKs complex Reactome
NFKB2 pathway0002249 TNFalpha NetPath
NFKB2 pathway0002284 TRAF6 mediated NF-kB activation Reactome
NFKB2 pathway0002355 TSLP NetPath
NFKB2 pathway0002356 TWEAK NetPath
NFKB2 pathway0002562 MAPK signaling pathway KEGG
NFKB2 pathway0002656 Pathways in cancer KEGG
NFKB2 pathway0002801 Hs_TNF_alpha_Signaling_Pathway_WP231_89895 WikiPathways
NKX3-1 pathway0000492 Coregulation of Androgen receptor activity PID
NKX3-1 pathway0000824 FOXA1 transcription factor network PID
NKX3-1 pathway0002656 Pathways in cancer KEGG
NKX3-1 pathway0002662 Prostate cancer KEGG
PAX4 pathway0001836 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells Reactome
PAX4 pathway0002631 Maturity onset diabetes of the young KEGG
POLR3A pathway0000532 Cytosolic sensors of pathogen-associated DNA Reactome
POLR3A pathway0001926 RNA Polymerase III Abortive And Retractive Initiation Reactome
POLR3A pathway0001927 RNA Polymerase III Chain Elongation Reactome
POLR3A pathway0001928 RNA Polymerase III Transcription Initiation From Type 1 Promoter Reactome
POLR3A pathway0001929 RNA Polymerase III Transcription Initiation From Type 2 Promoter Reactome
POLR3A pathway0001930 RNA Polymerase III Transcription Initiation From Type 3 Promoter Reactome
POLR3A pathway0001931 RNA Polymerase III Transcription Termination Reactome
POLR3A pathway0002492 Purine metabolism KEGG
POLR3A pathway0002494 Pyrimidine metabolism KEGG
POLR3A pathway0002605 Cytosolic DNA-sensing pathway KEGG
REL pathway0000072 Activation of NF-kappaB in B cells Reactome
REL pathway0000196 Apoptosis signaling pathway PANTHER
REL pathway0000250 Atypical NF-kappaB pathway PID
REL pathway0000270 BCR NetPath
REL pathway0001115 IL1 NetPath
REL pathway0001264 Leptin NetPath
REL pathway0001799 RANKL NetPath
REL pathway0001825 Regulation of Androgen receptor activity PID
REL pathway0002199 TCR NetPath
REL pathway0002249 TNFalpha NetPath
REL pathway0002801 Hs_TNF_alpha_Signaling_Pathway_WP231_89895 WikiPathways
REL pathway0002868 Hs_T-Cell_antigen_Receptor_(TCR)_Signaling_Pathway_WP69_89937 WikiPathways
REL pathway0002870 Hs_IL-1_signaling_pathway_WP195_89932 WikiPathways
REL pathway0002877 Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900 WikiPathways
SMAD3 pathway0000147 Alpha6Beta4Integrin NetPath
SMAD3 pathway0000176 AndrogenReceptor NetPath
SMAD3 pathway0000321 BMP signaling pathway ( TGF-beta_BMP Diagram(MolecularVariation) ) INOH
SMAD3 pathway0000631 Downregulation of SMAD2/3:SMAD4 transcriptional activity Reactome
SMAD3 pathway0000632 Downregulation of TGF-beta receptor signaling Reactome
SMAD3 pathway0000658 EGFR1 NetPath
SMAD3 pathway0000897 Gene expression of smad6/7 by R-smad:smad4 ( TGF-beta_super_family_signaling_pathway(canonical) ) INOH
SMAD3 pathway0000898 Gene expression of smad7 by R-smad:smad4 ( TGF-beta_super_family_signaling_pathway(canonical) ) INOH
SMAD3 pathway0001021 HIF-1-alpha transcription factor network PID
SMAD3 pathway0001078 ID NetPath
SMAD3 pathway0001455 Negative regulation of (transcription by R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) ) INOH
SMAD3 pathway0001517 Notch NetPath
SMAD3 pathway0001830 Regulation of cytoplasmic and nuclear SMAD2/3 signaling PID
SMAD3 pathway0001849 Regulation of nuclear SMAD2/3 signaling PID
SMAD3 pathway0001861 Regulation of Telomerase PID
SMAD3 pathway0002008 Signaling by Activin Reactome
SMAD3 pathway0002024 Signaling by NODAL Reactome
SMAD3 pathway0002067 SMAD2/3 MH2 Domain Mutants in Cancer Reactome
SMAD3 pathway0002068 SMAD2/3 Phosphorylation Motif Mutants in Cancer Reactome
SMAD3 pathway0002069 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Reactome
SMAD3 pathway0002214 TGF-beta receptor signaling activates SMADs Reactome
SMAD3 pathway0002215 TGF-beta receptor signaling PID
SMAD3 pathway0002217 TGF-beta signaling pathway PANTHER
SMAD3 pathway0002218 TGF-beta_super_family_signaling_pathway(canonical) ( TGF-beta_BMP Diagram(MolecularVariation) ) INOH
SMAD3 pathway0002222 TGF_beta_Receptor NetPath
SMAD3 pathway0002223 TGFBR1 KD Mutants in Cancer Reactome
SMAD3 pathway0002249 TNFalpha NetPath
SMAD3 pathway0002390 Validated targets of C-MYC transcriptional activation PID
SMAD3 pathway0002391 Validated targets of C-MYC transcriptional repression PID
SMAD3 pathway0002571 Cell cycle KEGG
SMAD3 pathway0002581 Endocytosis KEGG
SMAD3 pathway0002587 Wnt signaling pathway KEGG
SMAD3 pathway0002591 TGF-beta signaling pathway KEGG
SMAD3 pathway0002597 Adherens junction KEGG
SMAD3 pathway0002650 Chagas disease KEGG
SMAD3 pathway0002656 Pathways in cancer KEGG
SMAD3 pathway0002657 Colorectal cancer KEGG
SMAD3 pathway0002659 Pancreatic cancer KEGG
SMAD3 pathway0002680 Hs_Cell_Cycle_WP179_89516 WikiPathways
SMAD3 pathway0002740 Hs_Endoderm_Differentiation_WP2853_88152 WikiPathways
SMAD3 pathway0002751 Hs_Integrated_Cancer_Pathway_WP1971_82939 WikiPathways
SMAD3 pathway0002826 Hs_Mesodermal_Commitment_Pathway_WP2857_87780 WikiPathways
SMAD3 pathway0002853 Hs_TGF-beta_Signaling_Pathway_WP366_90028 WikiPathways
SMAD3 pathway0002863 Hs_Androgen_receptor_signaling_pathway_WP138_79958 WikiPathways
SPDEF pathway0000176 AndrogenReceptor NetPath
SPDEF pathway0001604 PDGF signaling pathway PANTHER
SPDEF pathway0001825 Regulation of Androgen receptor activity PID
SRF pathway0000492 Coregulation of Androgen receptor activity PID
SRF pathway0000692 ErbB1 downstream signaling PID
SRF pathway0001191 Interleukin signaling pathway PANTHER
SRF pathway0001572 p38 MAPK pathway PANTHER
SRF pathway0001574 p38 signaling mediated by MAPKAP kinases PID
SRF pathway0001604 PDGF signaling pathway PANTHER
SRF pathway0001605 PDGFR-alpha signaling pathway PID
SRF pathway0001606 PDGFR-beta signaling pathway PID
SRF pathway0001805 Ras Pathway PANTHER
SRF pathway0001894 RHO GTPases Activate Formins Reactome
SRF pathway0001903 RhoA signaling pathway PID
SRF pathway0002034 Signaling events mediated by HDAC Class II PID
SRF pathway0002340 Trk receptor signaling mediated by the MAPK pathway PID
SRF pathway0002562 MAPK signaling pathway KEGG
SRF pathway0002743 Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 WikiPathways
SRF pathway0002750 Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 WikiPathways
SRF pathway0002826 Hs_Mesodermal_Commitment_Pathway_WP2857_87780 WikiPathways
SRF pathway0002834 Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 WikiPathways
TFAP2A pathway0000377 Caspase Cascade in Apoptosis PID
TFAP2A pathway0002699 Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 WikiPathways
TFAP2A pathway0002747 Hs_Neural_Crest_Differentiation_WP2064_79263 WikiPathways
TFAP2A pathway0002841 Hs_Ectoderm_Differentiation_WP2858_89329 WikiPathways
TFAP2A pathway0002849 Hs_Hypothetical_Craniofacial_Development_Pathway_WP3655_88473 WikiPathways