General Details

Super-enhancer:SE_00_02600531
Genomic Locus: chr15: 42564248-42567844
Size/Length:3596bp
Conservation:0.0966022
BioSample Type:Tissue
Tissue Type:Muscle of trunk
Sample Name:muscle-of-trunk
Source:Roadmap
Element:1
Rank:531
ChIP Density(Case):13949.9628
ChIP Density(Input):533.2868

Super-enhancer Associated Network


* The complex regulatory networks formed by this SE , SE associated genes , TFs binding to the SE and their upstream pathways can be interactively visualized.


Fimo:
SE-Gene Linking Strategies:
Pathway Enriciment Threshold:
Top Pathway:
 



Super-enhancer Associated Statistics

Associated Gene Details

ROSE Overlap:TMEM87A,GANC
ROSE Proximal:.
ROSE Closest:TMEM87A
The Closest Active:TMEM87A

Factors Binding to Super-enhancer




Using these SE element regions to analyze by online tools GREAT *The TFs binding to this SE identified by ChIP-seq.

Chrome Element_Start Element_End TF TF Source TF_Start TF_End TF Class Master TF

Using these SE element regions to analyze by online tools GREAT * The TFs binding to this SE predicted by Motif.

Chrome Element_Start Element_End TF Database TF_Start TF_End Score P_Value TF Class Master TF
chr15 42564248 42567844 DPRX Transfac.V$DPRX_02 42565678 42565688 15.25450 7.29e-07 Helix-turn-helix domains N
chr15 42564248 42567844 DPRX Jolma2013.DPRX_DBD_2 42565678 42565688 15.21210 7.29e-07 Helix-turn-helix domains N
chr15 42564248 42567844 EFNA2 Transfac.V$ELF1_Q6 42566693 42566704 17.10910 4.33e-07 UNKNOW N
chr15 42564248 42567844 MAZ Transfac.V$MAZ_Q6_01 42566977 42566990 17.65930 1.92e-07 Zinc-coordinating DNA-binding domains N
chr15 42564248 42567844 NANOG Transfac.V$NANOG_02 42565048 42565067 15.53030 9.63e-07 Helix-turn-helix domains N
chr15 42564248 42567844 PDX1 Transfac.V$IPF1_Q5_01 42564341 42564350 11.10840 8.71e-07 Helix-turn-helix domains N
chr15 42564248 42567844 PITX2 Transfac.V$PITX2_Q2 42567312 42567322 16.09090 8.91e-07 Helix-turn-helix domains N
chr15 42564248 42567844 PITX2 Transfac.V$PITX2_Q6 42567312 42567321 15.07070 9.1e-07 Helix-turn-helix domains N
chr15 42564248 42567844 POLR3A Transfac.V$RPC155_01 42566961 42566976 23.71200 2.42e-10 ENCODE_TF N
chr15 42564248 42567844 SP1 Transfac.V$SP1_Q6_02 42566974 42566990 15.08410 1.3e-07 Zinc-coordinating DNA-binding domains N
chr15 42564248 42567844 SPI1 Transfac.V$PU1_Q4 42566693 42566711 16.75560 7.65e-07 Helix-turn-helix domains N
chr15 42564248 42567844 SPIB Transfac.V$SPIB_02 42565921 42565930 12.96390 9.51e-07 Helix-turn-helix domains N
chr15 42564248 42567844 SPIB Wei2010_mws.m-SPIB 42565921 42565930 12.93000 9.51e-07 Helix-turn-helix domains N
chr15 42564248 42567844 SPIC Transfac.V$SPIC_01 42565921 42565930 13.49400 9.51e-07 Helix-turn-helix domains N
chr15 42564248 42567844 SPIC Wei2010_mws.m-SPIC 42565921 42565930 13.46000 9.51e-07 Helix-turn-helix domains N
chr15 42564248 42567844 STAT3 Transfac.V$STAT3_03 42566549 42566564 16.64860 3.67e-07 Immunoglobulin fold N
chr15 42564248 42567844 STAT3 JASPAR2014.MA0144.2 42566553 42566563 16.10200 9.31e-07 Immunoglobulin fold N
chr15 42564248 42567844 WT1 Transfac.V$WT1_Q6_02 42566981 42566992 16.98900 3.77e-07 Zinc-coordinating DNA-binding domains N
chr15 42564248 42567844 ZFP42 Transfac.V$REX1_03 42565587 42565598 16.18180 5.03e-07 Zinc-coordinating DNA-binding domains N

The Upstream Pathways of TFs Binding to SE



TF Pathway ID Pathway Name Source
EFNA2 pathway0000674 EPH-ephrin mediated repulsion of cells Reactome
EFNA2 pathway0000675 EPH-Ephrin signaling Reactome
EFNA2 pathway0000676 EPHA-mediated growth cone collapse Reactome
EFNA2 pathway0000677 EPHA forward signaling PID
EFNA2 pathway0002592 Axon guidance KEGG
NANOG pathway0001701 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Reactome
NANOG pathway0001702 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation Reactome
NANOG pathway0002301 Transcriptional regulation of pluripotent stem cells Reactome
PDX1 pathway0000825 FOXA2 and FOXA3 transcription factor networks PID
PDX1 pathway0001834 Regulation of gene expression in beta cells Reactome
PDX1 pathway0001835 Regulation of gene expression in early pancreatic precursor cells Reactome
PDX1 pathway0002629 Type II diabetes mellitus KEGG
PDX1 pathway0002631 Maturity onset diabetes of the young KEGG
PITX2 pathway0001848 Regulation of nuclear beta catenin signaling and target gene transcription PID
PITX2 pathway0002591 TGF-beta signaling pathway KEGG
PITX2 pathway0002768 Hs_Heart_Development_WP1591_90186 WikiPathways
PITX2 pathway0002771 Hs_BMP_Signaling_Pathway_in_Eyelid_Development_WP3927_90735 WikiPathways
POLR3A pathway0000532 Cytosolic sensors of pathogen-associated DNA Reactome
POLR3A pathway0001926 RNA Polymerase III Abortive And Retractive Initiation Reactome
POLR3A pathway0001927 RNA Polymerase III Chain Elongation Reactome
POLR3A pathway0001928 RNA Polymerase III Transcription Initiation From Type 1 Promoter Reactome
POLR3A pathway0001929 RNA Polymerase III Transcription Initiation From Type 2 Promoter Reactome
POLR3A pathway0001930 RNA Polymerase III Transcription Initiation From Type 3 Promoter Reactome
POLR3A pathway0001931 RNA Polymerase III Transcription Termination Reactome
POLR3A pathway0002492 Purine metabolism KEGG
POLR3A pathway0002494 Pyrimidine metabolism KEGG
POLR3A pathway0002605 Cytosolic DNA-sensing pathway KEGG
SP1 pathway0000069 Activation of gene expression by SREBF (SREBP) Reactome
SP1 pathway0000176 AndrogenReceptor NetPath
SP1 pathway0000187 AP-1 transcription factor network PID
SP1 pathway0000335 C-MYB transcription factor network PID
SP1 pathway0000608 Direct p53 effectors PID
SP1 pathway0000648 E2F transcription factor network PID
SP1 pathway0000658 EGFR1 NetPath
SP1 pathway0000824 FOXA1 transcription factor network PID
SP1 pathway0000825 FOXA2 and FOXA3 transcription factor networks PID
SP1 pathway0000826 FOXM1 transcription factor network PID
SP1 pathway0001021 HIF-1-alpha transcription factor network PID
SP1 pathway0001022 HIF-2-alpha transcription factor network PID
SP1 pathway0001046 Huntington disease PANTHER
SP1 pathway0001122 IL2 signaling events mediated by STAT5 PID
SP1 pathway0001127 IL4-mediated signaling events PID
SP1 pathway0001264 Leptin NetPath
SP1 pathway0001543 Oncogene Induced Senescence Reactome
SP1 pathway0001582 p73 transcription factor network PID
SP1 pathway0001704 PPARA activates gene expression Reactome
SP1 pathway0001849 Regulation of nuclear SMAD2/3 signaling PID
SP1 pathway0001861 Regulation of Telomerase PID
SP1 pathway0001921 RNA polymerase II transcribes snRNA genes Reactome
SP1 pathway0002069 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Reactome
SP1 pathway0002222 TGF_beta_Receptor NetPath
SP1 pathway0002391 Validated targets of C-MYC transcriptional repression PID
SP1 pathway0002392 Validated transcriptional targets of AP1 family members Fra1 and Fra2 PID
SP1 pathway0002394 Validated transcriptional targets of TAp63 isoforms PID
SP1 pathway0002591 TGF-beta signaling pathway KEGG
SP1 pathway0002642 Huntington's disease KEGG
SP1 pathway0002699 Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 WikiPathways
SP1 pathway0002712 Hs_Leptin_signaling_pathway_WP2034_89856 WikiPathways
SP1 pathway0002718 Hs_Interleukin-11_Signaling_Pathway_WP2332_79525 WikiPathways
SP1 pathway0002731 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 WikiPathways
SP1 pathway0002811 Hs_Estrogen_signaling_pathway_WP712_78491 WikiPathways
SP1 pathway0002812 Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 WikiPathways
SP1 pathway0002853 Hs_TGF-beta_Signaling_Pathway_WP366_90028 WikiPathways
SP1 pathway0002862 Hs_AGE-RAGE_pathway_WP2324_89798 WikiPathways
SP1 pathway0002863 Hs_Androgen_receptor_signaling_pathway_WP138_79958 WikiPathways
SP1 pathway0002866 Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 WikiPathways
SPI1 pathway0000335 C-MYB transcription factor network PID
SPI1 pathway0000702 ERK cascade ( FGF8 signaling (Mouse) ) INOH
SPI1 pathway0000703 ERK cascade ( FGF8 signaling (Xenopus) ) INOH
SPI1 pathway0000781 FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) INOH
SPI1 pathway0000782 FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) INOH
SPI1 pathway0000916 Glucocorticoid receptor regulatory network PID
SPI1 pathway0001127 IL4-mediated signaling events PID
SPI1 pathway0001128 IL4 NetPath
SPI1 pathway0001191 Interleukin signaling pathway PANTHER
SPI1 pathway0001799 RANKL NetPath
SPI1 pathway0001857 Regulation of retinoblastoma protein PID
SPI1 pathway0002391 Validated targets of C-MYC transcriptional repression PID
SPI1 pathway0002656 Pathways in cancer KEGG
SPI1 pathway0002668 Acute myeloid leukemia KEGG
SPI1 pathway0002874 Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016 WikiPathways
SPIC pathway0001191 Interleukin signaling pathway PANTHER
STAT3 pathway0000176 AndrogenReceptor NetPath
STAT3 pathway0000177 Angiogenesis PANTHER
STAT3 pathway0000226 Association of TriC/CCT with target proteins during biosynthesis Reactome
STAT3 pathway0000270 BCR NetPath
STAT3 pathway0000323 BMP2 signaling pathway(through Smad) ( TGF-beta_BMP Diagram(MolecularVariation) ) INOH
STAT3 pathway0000513 CXCR4-mediated signaling events PID
STAT3 pathway0000633 Downstream signal transduction Reactome
STAT3 pathway0000652 EGF receptor signaling pathway PANTHER
STAT3 pathway0000658 EGFR1 NetPath
STAT3 pathway0000688 EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) INOH
STAT3 pathway0000692 ErbB1 downstream signaling PID
STAT3 pathway0000695 ErbB2/ErbB3 signaling events PID
STAT3 pathway0000780 FGF signaling pathway PID
STAT3 pathway0000899 Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) INOH
STAT3 pathway0000900 Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) INOH
STAT3 pathway0000901 Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) INOH
STAT3 pathway0000966 GMCSF-mediated signaling events PID
STAT3 pathway0000976 Growth hormone receptor signaling Reactome
STAT3 pathway0001079 IFN-gamma pathway PID
STAT3 pathway0001081 IFN alpha signaling pathway(JAK1 TYK2 STAT1 STAT3) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) INOH
STAT3 pathway0001083 IFN alpha signaling pathway(JAK1 TYK2 STAT3) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) INOH
STAT3 pathway0001102 IL-10 signaling pathway(JAK1 TYK2 STAT3) ( IL-10 signaling(JAK1 TYK2 STAT3) ) INOH
STAT3 pathway0001106 IL-23 signaling pathway(JAK2 TYK2 STAT3 STAT4) ( IL-23 signaling(JAK2 TYK2 STAT3 STAT4) ) INOH
STAT3 pathway0001111 IL-6 signaling pathway(JAK1 JAK2 STAT3) ( IL-6 signaling(JAK1 JAK2 STAT3) ) INOH
STAT3 pathway0001112 IL-7 NetPath
STAT3 pathway0001115 IL1 NetPath
STAT3 pathway0001116 IL12-mediated signaling events PID
STAT3 pathway0001117 IL12 signaling mediated by STAT4 PID
STAT3 pathway0001119 IL2-mediated signaling events PID
STAT3 pathway0001120 IL2 NetPath
STAT3 pathway0001123 IL23-mediated signaling events PID
STAT3 pathway0001124 IL27-mediated signaling events PID
STAT3 pathway0001126 IL3 NetPath
STAT3 pathway0001128 IL4 NetPath
STAT3 pathway0001130 IL5 NetPath
STAT3 pathway0001131 IL6-mediated signaling events PID
STAT3 pathway0001132 IL6 NetPath
STAT3 pathway0001135 IL9 NetPath
STAT3 pathway0001147 Inflammation mediated by chemokine and cytokine signaling pathway PANTHER
STAT3 pathway0001188 Interleukin-6 signaling Reactome
STAT3 pathway0001191 Interleukin signaling pathway PANTHER
STAT3 pathway0001226 JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) INOH
STAT3 pathway0001228 JAK/STAT signaling pathway PANTHER
STAT3 pathway0001246 KitReceptor NetPath
STAT3 pathway0001264 Leptin NetPath
STAT3 pathway0001279 LIF signaling pathway ( LIF signaling(JAK1 JAK2 STAT3) ) INOH
STAT3 pathway0001479 Neurotrophic factor-mediated Trk receptor signaling PID
STAT3 pathway0001516 Notch-mediated HES/HEY network PID
STAT3 pathway0001517 Notch NetPath
STAT3 pathway0001604 PDGF signaling pathway PANTHER
STAT3 pathway0001606 PDGFR-beta signaling pathway PID
STAT3 pathway0001697 Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) INOH
STAT3 pathway0001701 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Reactome
STAT3 pathway0001727 Prolactin NetPath
STAT3 pathway0001788 RAC1 signaling pathway PID
STAT3 pathway0001805 Ras Pathway PANTHER
STAT3 pathway0001980 Senescence-Associated Secretory Phenotype (SASP) Reactome
STAT3 pathway0002010 Signaling by cytosolic FGFR1 fusion mutants Reactome
STAT3 pathway0002022 Signaling by Leptin Reactome
STAT3 pathway0002030 Signaling by SCF-KIT Reactome
STAT3 pathway0002033 Signaling events mediated by HDAC Class I PID
STAT3 pathway0002038 Signaling events mediated by PTP1B PID
STAT3 pathway0002039 Signaling events mediated by Stem cell factor receptor (c-Kit) PID
STAT3 pathway0002040 Signaling events mediated by TCPTP PID
STAT3 pathway0002301 Transcriptional regulation of pluripotent stem cells Reactome
STAT3 pathway0002354 TSH NetPath
STAT3 pathway0002355 TSLP NetPath
STAT3 pathway0002568 Chemokine signaling pathway KEGG
STAT3 pathway0002606 Jak-STAT signaling pathway KEGG
STAT3 pathway0002628 Adipocytokine signaling pathway KEGG
STAT3 pathway0002652 Toxoplasmosis KEGG
STAT3 pathway0002655 Hepatitis C KEGG
STAT3 pathway0002656 Pathways in cancer KEGG
STAT3 pathway0002659 Pancreatic cancer KEGG
STAT3 pathway0002668 Acute myeloid leukemia KEGG
STAT3 pathway0002682 Hs_Interferon_type_I_signaling_pathways_WP585_85198 WikiPathways
STAT3 pathway0002700 Hs_Signaling_of_Hepatocyte_Growth_Factor_Receptor_WP313_79946 WikiPathways
STAT3 pathway0002712 Hs_Leptin_signaling_pathway_WP2034_89856 WikiPathways
STAT3 pathway0002717 Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640 WikiPathways
STAT3 pathway0002718 Hs_Interleukin-11_Signaling_Pathway_WP2332_79525 WikiPathways
STAT3 pathway0002735 Hs_PDGF_Pathway_WP2526_82681 WikiPathways
STAT3 pathway0002743 Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 WikiPathways
STAT3 pathway0002746 Hs_Dopaminergic_Neurogenesis_WP2855_87239 WikiPathways
STAT3 pathway0002760 Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 WikiPathways
STAT3 pathway0002761 Hs_Amino_Acid_metabolism_WP3925_90737 WikiPathways
STAT3 pathway0002772 Hs_Vitamin_B12_Metabolism_WP1533_85340 WikiPathways
STAT3 pathway0002781 Hs_ESC_Pluripotency_Pathways_WP3931_91005 WikiPathways
STAT3 pathway0002786 Hs_MicroRNAs_in_cardiomyocyte_hypertrophy_WP1544_89794 WikiPathways
STAT3 pathway0002810 Hs_Regulation_of_Microtubule_Cytoskeleton_WP2038_90889 WikiPathways
STAT3 pathway0002829 Hs_Kit_receptor_signaling_pathway_WP304_78799 WikiPathways
STAT3 pathway0002837 Hs_IL-5_Signaling_Pathway_WP127_78498 WikiPathways
STAT3 pathway0002844 Hs_IL-2_Signaling_Pathway_WP49_91243 WikiPathways
STAT3 pathway0002858 Hs_IL-6_signaling_pathway_WP364_89832 WikiPathways
STAT3 pathway0002861 Hs_RalA_downstream_regulated_genes_WP2290_79988 WikiPathways
STAT3 pathway0002864 Hs_IL-4_Signaling_Pathway_WP395_89828 WikiPathways
STAT3 pathway0002865 Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803 WikiPathways
STAT3 pathway0002866 Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 WikiPathways
STAT3 pathway0002871 Hs_IL-3_Signaling_Pathway_WP286_78583 WikiPathways
STAT3 pathway0002873 Hs_Notch_Signaling_Pathway_WP61_78592 WikiPathways
STAT3 pathway0002879 Hs_IL-9_Signaling_Pathway_WP22_79264 WikiPathways
WT1 pathway0000318 BMP signaling in Drosophila ( BMP signaling in Drosophila ) INOH
WT1 pathway0000319 BMP signaling in Drosophila (dorsal midline) ( BMP signaling in Drosophila ) INOH
WT1 pathway0000320 BMP signaling in Drosophila (dorsolateral) ( BMP signaling in Drosophila ) INOH
WT1 pathway0000321 BMP signaling pathway ( TGF-beta_BMP Diagram(MolecularVariation) ) INOH
WT1 pathway0001582 p73 transcription factor network PID
WT1 pathway0001861 Regulation of Telomerase PID
WT1 pathway0002218 TGF-beta_super_family_signaling_pathway(canonical) ( TGF-beta_BMP Diagram(MolecularVariation) ) INOH