General Details

Super-enhancer:SE_00_02600318
Genomic Locus: chr16: 31082634-31100607
Size/Length:17973bp
Conservation:0.181113
BioSample Type:Tissue
Tissue Type:Muscle of trunk
Sample Name:muscle-of-trunk
Source:Roadmap
Element:3
Rank:318
ChIP Density(Case):19191.5694
ChIP Density(Input):2474.8821

Super-enhancer Associated Network


* The complex regulatory networks formed by this SE , SE associated genes , TFs binding to the SE and their upstream pathways can be interactively visualized.


Fimo:
SE-Gene Linking Strategies:
Pathway Enriciment Threshold:
Top Pathway:
 



Super-enhancer Associated Statistics

Associated Gene Details

ROSE Overlap:PRSS53,ZNF646,ZNF668
ROSE Proximal:VKORC1,STX4,ZNF668,MYST1,BCKDK,PRSS8
ROSE Closest:ZNF646
The Closest Active:ZNF646

Factors Binding to Super-enhancer




Using these SE element regions to analyze by online tools GREAT *The TFs binding to this SE identified by ChIP-seq.

Chrome Element_Start Element_End TF TF Source TF_Start TF_End TF Class Master TF

Using these SE element regions to analyze by online tools GREAT * The TFs binding to this SE predicted by Motif.

Chrome Element_Start Element_End TF Database TF_Start TF_End Score P_Value TF Class Master TF
chr16 31099502 31100607 ATF2 Transfac.V$ATF2_Q5 31099771 31099782 14.17580 8.62e-07 Basic domains N
chr16 31082634 31086637 ATF7 Transfac.V$ATF7_01 31083316 31083329 19.30990 2.49e-07 Basic domains N
chr16 31082634 31086637 ATF7 Transfac.V$ATF7_01 31083316 31083329 18.36620 6.41e-07 Basic domains N
chr16 31082634 31086637 ATF7 Jolma2013.ATF7_DBD 31083316 31083329 19.27270 2.38e-07 Basic domains N
chr16 31082634 31086637 ATF7 Jolma2013.ATF7_DBD 31083316 31083329 18.31310 6.41e-07 Basic domains N
chr16 31082634 31086637 CREB5 Transfac.V$CREB5_01 31083317 31083328 18.18180 7.58e-07 Basic domains N
chr16 31082634 31086637 CREB5 Transfac.V$CREB5_01 31083317 31083328 18.00000 9.85e-07 Basic domains N
chr16 31082634 31086637 CREB5 Jolma2013.Creb5_DBD 31083317 31083328 18.15150 7.58e-07 Basic domains N
chr16 31082634 31086637 CREB5 Jolma2013.Creb5_DBD 31083317 31083328 17.96970 9.26e-07 Basic domains N
chr16 31082634 31086637 ELF1 JASPAR2014.MA0473.1 31085727 31085739 18.91840 2.97e-08 Helix-turn-helix domains N
chr16 31082634 31086637 ETV6 Transfac.V$ETV6_01 31085685 31085699 17.89090 4.6e-07 Helix-turn-helix domains Y
chr16 31082634 31086637 ETV6 Transfac.V$ETV6_02 31085109 31085118 15.89800 9.94e-07 Helix-turn-helix domains Y
chr16 31082634 31086637 ETV6 Jolma2013.ETV6_full 31085685 31085699 17.87880 4.7e-07 Helix-turn-helix domains Y
chr16 31082634 31086637 ETV6 Jolma2013.ETV6_full_2 31085109 31085118 15.87880 9.94e-07 Helix-turn-helix domains Y
chr16 31095304 31099162 GC Transfac.V$GC_01 31097616 31097629 15.66200 7.46e-07 UNKNOW N
chr16 31095304 31099162 GLIS2 Transfac.V$GLIS2_04 31098754 31098767 14.00570 7.82e-07 Zinc-coordinating DNA-binding domains N
chr16 31095304 31099162 GLIS2 Uniprobe.UP00024_2 31098754 31098767 13.96260 7.58e-07 Zinc-coordinating DNA-binding domains N
chr16 31095304 31099162 HESX1 Transfac.V$HESX1_01 31095745 31095754 13.54550 9.51e-07 Helix-turn-helix domains N
chr16 31095304 31099162 HESX1 Jolma2013.HESX1_DBD 31095745 31095754 13.52530 9.51e-07 Helix-turn-helix domains N
chr16 31095304 31099162 INSM1 Transfac.V$INSM1_01 31095657 31095668 17.22000 6.58e-07 Zinc-coordinating DNA-binding domains N
chr16 31095304 31099162 INSM1 JASPAR2014.MA0155.1 31095657 31095668 17.22000 6.58e-07 Zinc-coordinating DNA-binding domains N
chr16 31099502 31100607 IRF1 JASPAR2014.MA0050.2 31099731 31099751 18.95160 2.66e-07 Helix-turn-helix domains N
chr16 31099502 31100607 IRF3 Transfac.V$IRF3_Q3 31099737 31099749 16.76360 1.07e-07 Helix-turn-helix domains N
chr16 31082634 31086637 JDP2 Jolma2013.Jdp2_DBD_2 31083317 31083328 18.58590 7.06e-07 Basic domains N
chr16 31099502 31100607 KLF1 JASPAR2014.MA0493.1 31100038 31100048 17.34850 2.65e-07 Zinc-coordinating DNA-binding domains N
chr16 31095304 31099162 KLF15 Transfac.V$KLF15_Q2 31096840 31096853 15.91890 8.54e-07 Zinc-coordinating DNA-binding domains N
chr16 31082634 31086637 LEF1 Transfac.V$LEF1_04 31086121 31086137 17.01200 9.24e-07 Other all-alpha-helical DNA-binding domains N
chr16 31082634 31086637 LEF1 Uniprobe.UP00067_1 31086121 31086137 16.95960 9.78e-07 Other all-alpha-helical DNA-binding domains N
chr16 31082634 31086637 MAZ Transfac.V$MAZ_Q6_01 31085851 31085864 18.17580 8.51e-08 Zinc-coordinating DNA-binding domains N
chr16 31095304 31099162 MYF5 Transfac.V$MYF5_Q6 31095345 31095357 17.16940 6.35e-07 Basic domains N
chr16 31095304 31099162 MYOD1 Transfac.V$MYOD_01 31097720 31097731 16.27420 8.81e-07 Basic domains Y
chr16 31082634 31086637 NRF1 JASPAR2014.MA0506.1 31085965 31085975 17.96360 2.77e-07 Basic domains N
chr16 31082634 31086637 PAX5 Transfac.V$PAX5_01 31083879 31083906 18.87270 3.01e-07 Helix-turn-helix domains N
chr16 31099502 31100607 PAX9 Transfac.V$PAX9_B 31100293 31100316 21.11290 7.1e-08 Helix-turn-helix domains N
chr16 31082634 31086637 PITX2 Transfac.V$PITX2_Q2 31082753 31082763 16.09090 8.91e-07 Helix-turn-helix domains N
chr16 31095304 31099162 PITX2 Transfac.V$PITX2_Q2 31098583 31098593 16.09090 8.91e-07 Helix-turn-helix domains N
chr16 31082634 31086637 PITX2 Transfac.V$PITX2_Q6 31082754 31082763 15.07070 9.1e-07 Helix-turn-helix domains N
chr16 31095304 31099162 PITX2 Transfac.V$PITX2_Q6 31098584 31098593 15.07070 9.1e-07 Helix-turn-helix domains N
chr16 31082634 31086637 POLR3A Transfac.V$RPC155_01 31082701 31082716 23.71200 2.42e-10 ENCODE_TF N
chr16 31082634 31086637 REST Transfac.V$NRSF_Q4 31084772 31084790 18.59000 1.71e-07 Zinc-coordinating DNA-binding domains N
chr16 31095304 31099162 RFX1 Transfac.V$RFX1_01 31097504 31097520 16.16160 9.1e-07 Helix-turn-helix domains N
chr16 31082634 31086637 SOX21 Transfac.V$SOX21_06 31085745 31085760 18.90320 1.91e-07 Other all-alpha-helical DNA-binding domains N
chr16 31082634 31086637 SOX7 Transfac.V$SOX7_05 31085745 31085760 15.09860 6.23e-07 Other all-alpha-helical DNA-binding domains N
chr16 31082634 31086637 SP1 Transfac.V$SP1_Q6_02 31085077 31085093 13.87850 8.13e-07 Zinc-coordinating DNA-binding domains N
chr16 31082634 31086637 SP3 Transfac.V$SP3_Q3 31083878 31083891 16.96770 9.88e-07 Zinc-coordinating DNA-binding domains Y
chr16 31082634 31086637 SPI1 JASPAR2014.MA0080.3 31085726 31085740 17.00000 7.65e-07 Helix-turn-helix domains N
chr16 31082634 31086637 SPIC Wei2010_pbm.m-SPIC 31085690 31085699 16.17170 9.51e-07 Helix-turn-helix domains N
chr16 31099502 31100607 STAT3 JASPAR2014.MA0144.2 31099619 31099629 16.10200 9.31e-07 Immunoglobulin fold N
chr16 31082634 31086637 TCF3 Transfac.V$TCF3_04 31086121 31086137 16.27710 9.44e-07 Basic domains N
chr16 31082634 31086637 TCF3 Transfac.V$TCF3_06 31083430 31083439 13.78850 9.51e-07 Basic domains N
chr16 31082634 31086637 TCF3 Jolma2013.TCF3_DBD 31083430 31083439 13.74750 9.51e-07 Basic domains N
chr16 31082634 31086637 TCF3 Uniprobe.UP00058_1 31086121 31086137 16.28000 8.66e-07 Basic domains N
chr16 31082634 31086637 TEF Transfac.V$TEF_Q6 31086395 31086406 17.17740 5.92e-07 Basic domains N
chr16 31095304 31099162 THRB Jolma2013.THRB_DBD_3 31098624 31098643 17.02000 4.94e-07 TcoF-DB_TF N
chr16 31099502 31100607 TRIM63 Transfac.V$IRF_Q6 31099736 31099750 16.98890 7.33e-07 UNKNOW N
chr16 31082634 31086637 ZNF263 JASPAR2014.MA0528.1 31083890 31083910 17.68000 5.09e-07 Zinc-coordinating DNA-binding domains N
chr16 31082634 31086637 ZNF263 JASPAR2014.MA0528.1 31085802 31085822 17.20000 7.36e-07 Zinc-coordinating DNA-binding domains N
chr16 31082634 31086637 ZNF263 JASPAR2014.MA0528.1 31085819 31085839 16.96000 8.82e-07 Zinc-coordinating DNA-binding domains N
chr16 31082634 31086637 ZNF263 JASPAR2014.MA0528.1 31085831 31085851 17.48000 5.94e-07 Zinc-coordinating DNA-binding domains N
chr16 31082634 31086637 ZNF263 JASPAR2014.MA0528.1 31085848 31085868 19.28000 1.37e-07 Zinc-coordinating DNA-binding domains N
chr16 31095304 31099162 ZNF263 JASPAR2014.MA0528.1 31097619 31097639 19.00000 1.74e-07 Zinc-coordinating DNA-binding domains N

The Upstream Pathways of TFs Binding to SE



TF Pathway ID Pathway Name Source
ATF2 pathway0000080 Activation of the AP-1 family of transcription factors Reactome
ATF2 pathway0000176 AndrogenReceptor NetPath
ATF2 pathway0000187 AP-1 transcription factor network PID
ATF2 pathway0000196 Apoptosis signaling pathway PANTHER
ATF2 pathway0000229 ATF-2 transcription factor network PID
ATF2 pathway0000270 BCR NetPath
ATF2 pathway0000390 CDC42 signaling events PID
ATF2 pathway0000430 Circadian Clock Reactome
ATF2 pathway0000692 ErbB1 downstream signaling PID
ATF2 pathway0000984 HATs acetylate histones Reactome
ATF2 pathway0001115 IL1 NetPath
ATF2 pathway0001116 IL12-mediated signaling events PID
ATF2 pathway0001120 IL2 NetPath
ATF2 pathway0001126 IL3 NetPath
ATF2 pathway0001128 IL4 NetPath
ATF2 pathway0001130 IL5 NetPath
ATF2 pathway0001194 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine SMPDB
ATF2 pathway0001195 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine SMPDB
ATF2 pathway0001246 KitReceptor NetPath
ATF2 pathway0001264 Leptin NetPath
ATF2 pathway0001569 p38 cascade ( BMP2 signaling(through TAK1) ) INOH
ATF2 pathway0001570 p38 cascade ( TGF-beta signaling(through TAK1) ) INOH
ATF2 pathway0001571 p38 cascade ( Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, p38 cascade) ) INOH
ATF2 pathway0001788 RAC1 signaling pathway PID
ATF2 pathway0001799 RANKL NetPath
ATF2 pathway0001805 Ras Pathway PANTHER
ATF2 pathway0001849 Regulation of nuclear SMAD2/3 signaling PID
ATF2 pathway0001857 Regulation of retinoblastoma protein PID
ATF2 pathway0001903 RhoA signaling pathway PID
ATF2 pathway0002044 Signaling mediated by p38-alpha and p38-beta PID
ATF2 pathway0002199 TCR NetPath
ATF2 pathway0002217 TGF-beta signaling pathway PANTHER
ATF2 pathway0002222 TGF_beta_Receptor NetPath
ATF2 pathway0002273 TP53 Regulates Transcription of DNA Repair Genes Reactome
ATF2 pathway0002299 Transcriptional activation of mitochondrial biogenesis Reactome
ATF2 pathway0002354 TSH NetPath
ATF2 pathway0002473 p38 cascade ( IL-1 signaling pathway (through p38 cascade) ) INOH
ATF2 pathway0002474 p38 cascade ( Toll-like receptor signaling pathway (p38 cascade) ) INOH
ATF2 pathway0002562 MAPK signaling pathway KEGG
ATF2 pathway0002743 Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 WikiPathways
ATF2 pathway0002752 Hs_ATM_Signaling_Pathway_WP2516_90247 WikiPathways
ATF2 pathway0002753 Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 WikiPathways
ATF2 pathway0002754 Hs_Structural_Pathway_of_Interleukin_1_(IL-1)_WP2637_87707 WikiPathways
ATF2 pathway0002773 Hs_Energy_Metabolism_WP1541_91584 WikiPathways
ATF2 pathway0002853 Hs_TGF-beta_Signaling_Pathway_WP366_90028 WikiPathways
ATF2 pathway0002862 Hs_AGE-RAGE_pathway_WP2324_89798 WikiPathways
ATF2 pathway0002864 Hs_IL-4_Signaling_Pathway_WP395_89828 WikiPathways
ATF2 pathway0002870 Hs_IL-1_signaling_pathway_WP195_89932 WikiPathways
ATF7 pathway0000196 Apoptosis signaling pathway PANTHER
ATF7 pathway0001857 Regulation of retinoblastoma protein PID
CREB5 pathway0001005 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway PANTHER
CREB5 pathway0002297 Transcription regulation by bZIP transcription factor PANTHER
CREB5 pathway0002633 Vasopressin-regulated water reabsorption KEGG
CREB5 pathway0002642 Huntington's disease KEGG
CREB5 pathway0002662 Prostate cancer KEGG
CREB5 pathway0002818 Hs_MFAP5-mediated_ovarian_cancer_cell_motility_and_invasiveness_WP3301_87836 WikiPathways
ELF1 pathway0000178 Angiopoietin receptor Tie2-mediated signaling PID
ELF1 pathway0000187 AP-1 transcription factor network PID
ELF1 pathway0001122 IL2 signaling events mediated by STAT5 PID
ELF1 pathway0001604 PDGF signaling pathway PANTHER
ELF1 pathway0001857 Regulation of retinoblastoma protein PID
ETV6 pathway0000702 ERK cascade ( FGF8 signaling (Mouse) ) INOH
ETV6 pathway0000703 ERK cascade ( FGF8 signaling (Xenopus) ) INOH
ETV6 pathway0000781 FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) INOH
ETV6 pathway0000782 FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) INOH
ETV6 pathway0002588 Dorso-ventral axis formation KEGG
GC pathway0002430 Vitamin D (calciferol) metabolism Reactome
GC pathway0002431 Vitamin D metabolism and pathway PANTHER
HESX1 pathway0002841 Hs_Ectoderm_Differentiation_WP2858_89329 WikiPathways
INSM1 pathway0001836 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells Reactome
IRF1 pathway0000747 Factors involved in megakaryocyte development and platelet production Reactome
IRF1 pathway0000916 Glucocorticoid receptor regulatory network PID
IRF1 pathway0001079 IFN-gamma pathway PID
IRF1 pathway0001117 IL12 signaling mediated by STAT4 PID
IRF1 pathway0001131 IL6-mediated signaling events PID
IRF1 pathway0001180 Interferon alpha/beta signaling Reactome
IRF1 pathway0001181 Interferon gamma signaling Reactome
IRF1 pathway0001861 Regulation of Telomerase PID
IRF1 pathway0002282 TRAF6 mediated IRF7 activation Reactome
IRF1 pathway0002655 Hepatitis C KEGG
IRF1 pathway0002686 Hs_Tryptophan_metabolism_WP465_85055 WikiPathways
IRF3 pathway0000070 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Reactome
IRF3 pathway0000747 Factors involved in megakaryocyte development and platelet production Reactome
IRF3 pathway0001180 Interferon alpha/beta signaling Reactome
IRF3 pathway0001181 Interferon gamma signaling Reactome
IRF3 pathway0001212 IRF3-mediated induction of type I IFN Reactome
IRF3 pathway0001213 IRF3 mediated activation of type 1 IFN Reactome
IRF3 pathway0001219 ISG15 antiviral mechanism Reactome
IRF3 pathway0001297 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Reactome
IRF3 pathway0001469 Negative regulators of RIG-I/MDA5 signaling Reactome
IRF3 pathway0001843 Regulation of innate immune responses to cytosolic DNA Reactome
IRF3 pathway0002264 Toll receptor signaling pathway PANTHER
IRF3 pathway0002278 TRAF3-dependent IRF activation pathway Reactome
IRF3 pathway0002282 TRAF6 mediated IRF7 activation Reactome
IRF3 pathway0002602 Toll-like receptor signaling pathway KEGG
IRF3 pathway0002604 RIG-I-like receptor signaling pathway KEGG
IRF3 pathway0002605 Cytosolic DNA-sensing pathway KEGG
IRF3 pathway0002655 Hepatitis C KEGG
IRF3 pathway0002782 Hs_p38_MAPK_Signaling_Pathway_WP400_72084 WikiPathways
IRF3 pathway0002789 Hs_Complement_and_Coagulation_Cascades_WP558_90196 WikiPathways
IRF3 pathway0002824 Hs_RIG-I-like_Receptor_Signaling_WP3865_88186 WikiPathways
IRF3 pathway0002845 Hs_TLR4_Signaling_and_Tolerance_WP3851_90114 WikiPathways
JDP2 pathway0000229 ATF-2 transcription factor network PID
LEF1 pathway0000154 Alzheimer disease-presenilin pathway PANTHER
LEF1 pathway0000309 Binding of TCF/LEF:CTNNB1 to target gene promoters Reactome
LEF1 pathway0000335 C-MYB transcription factor network PID
LEF1 pathway0000340 Ca2+ pathway Reactome
LEF1 pathway0000341 Cadherin signaling pathway PANTHER
LEF1 pathway0000355 Canonical Wnt signaling pathway ( C. elegans endoderm induction Wnt signaling pathway Diagram ) INOH
LEF1 pathway0000356 Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram ) INOH
LEF1 pathway0000357 Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram ) INOH
LEF1 pathway0000358 Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) INOH
LEF1 pathway0000359 Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram ) INOH
LEF1 pathway0000549 Deactivation of the beta-catenin transactivating complex Reactome
LEF1 pathway0000816 Formation of the beta-catenin:TCF transactivating complex Reactome
LEF1 pathway0001170 Integrin-linked kinase signaling PID
LEF1 pathway0001315 Mammalian Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) INOH
LEF1 pathway0001517 Notch NetPath
LEF1 pathway0001848 Regulation of nuclear beta catenin signaling and target gene transcription PID
LEF1 pathway0001876 Repression of WNT target genes Reactome
LEF1 pathway0002046 Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) INOH
LEF1 pathway0002047 Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) INOH
LEF1 pathway0002048 Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) INOH
LEF1 pathway0002049 Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) INOH
LEF1 pathway0002050 Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) INOH
LEF1 pathway0002051 Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) INOH
LEF1 pathway0002052 Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram ) INOH
LEF1 pathway0002053 Signaling without Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) INOH
LEF1 pathway0002054 Signaling without Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) INOH
LEF1 pathway0002055 Signaling without Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) INOH
LEF1 pathway0002056 Signaling without Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) INOH
LEF1 pathway0002057 Signaling without Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) INOH
LEF1 pathway0002058 Signaling without Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) INOH
LEF1 pathway0002222 TGF_beta_Receptor NetPath
LEF1 pathway0002439 Wnt NetPath
LEF1 pathway0002449 Wnt signaling pathway PANTHER
LEF1 pathway0002587 Wnt signaling pathway KEGG
LEF1 pathway0002597 Adherens junction KEGG
LEF1 pathway0002627 Melanogenesis KEGG
LEF1 pathway0002656 Pathways in cancer KEGG
LEF1 pathway0002657 Colorectal cancer KEGG
LEF1 pathway0002660 Endometrial cancer KEGG
LEF1 pathway0002662 Prostate cancer KEGG
LEF1 pathway0002668 Acute myeloid leukemia KEGG
LEF1 pathway0002677 Arrhythmogenic right ventricular cardiomyopathy (ARVC) KEGG
LEF1 pathway0002724 Hs_Wnt_Signaling_Pathway_Netpath_WP363_78571 WikiPathways
LEF1 pathway0002740 Hs_Endoderm_Differentiation_WP2853_88152 WikiPathways
LEF1 pathway0002826 Hs_Mesodermal_Commitment_Pathway_WP2857_87780 WikiPathways
MYF5 pathway0000393 CDO in myogenesis Reactome
MYF5 pathway0001078 ID NetPath
MYF5 pathway0001848 Regulation of nuclear beta catenin signaling and target gene transcription PID
MYOD1 pathway0000335 C-MYB transcription factor network PID
MYOD1 pathway0000393 CDO in myogenesis Reactome
MYOD1 pathway0001078 ID NetPath
MYOD1 pathway0001516 Notch-mediated HES/HEY network PID
MYOD1 pathway0001849 Regulation of nuclear SMAD2/3 signaling PID
MYOD1 pathway0001857 Regulation of retinoblastoma protein PID
MYOD1 pathway0002035 Signaling events mediated by HDAC Class III PID
MYOD1 pathway0002878 Hs_ID_signaling_pathway_WP53_67360 WikiPathways
NRF1 pathway0001704 PPARA activates gene expression Reactome
NRF1 pathway0002299 Transcriptional activation of mitochondrial biogenesis Reactome
NRF1 pathway0002642 Huntington's disease KEGG
NRF1 pathway0002773 Hs_Energy_Metabolism_WP1541_91584 WikiPathways
NRF1 pathway0002823 Hs_Mitochondrial_Gene_Expression_WP391_71373 WikiPathways
PAX5 pathway0000335 C-MYB transcription factor network PID
PAX5 pathway0001078 ID NetPath
PAX9 pathway0002740 Hs_Endoderm_Differentiation_WP2853_88152 WikiPathways
PITX2 pathway0001848 Regulation of nuclear beta catenin signaling and target gene transcription PID
PITX2 pathway0002591 TGF-beta signaling pathway KEGG
PITX2 pathway0002768 Hs_Heart_Development_WP1591_90186 WikiPathways
PITX2 pathway0002771 Hs_BMP_Signaling_Pathway_in_Eyelid_Development_WP3927_90735 WikiPathways
POLR3A pathway0000532 Cytosolic sensors of pathogen-associated DNA Reactome
POLR3A pathway0001926 RNA Polymerase III Abortive And Retractive Initiation Reactome
POLR3A pathway0001927 RNA Polymerase III Chain Elongation Reactome
POLR3A pathway0001928 RNA Polymerase III Transcription Initiation From Type 1 Promoter Reactome
POLR3A pathway0001929 RNA Polymerase III Transcription Initiation From Type 2 Promoter Reactome
POLR3A pathway0001930 RNA Polymerase III Transcription Initiation From Type 3 Promoter Reactome
POLR3A pathway0001931 RNA Polymerase III Transcription Termination Reactome
POLR3A pathway0002492 Purine metabolism KEGG
POLR3A pathway0002494 Pyrimidine metabolism KEGG
POLR3A pathway0002605 Cytosolic DNA-sensing pathway KEGG
REST pathway0000986 HDACs deacetylate histones Reactome
REST pathway0002642 Huntington's disease KEGG
REST pathway0002812 Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 WikiPathways
SOX7 pathway0000549 Deactivation of the beta-catenin transactivating complex Reactome
SOX7 pathway0002740 Hs_Endoderm_Differentiation_WP2853_88152 WikiPathways
SP1 pathway0000069 Activation of gene expression by SREBF (SREBP) Reactome
SP1 pathway0000176 AndrogenReceptor NetPath
SP1 pathway0000187 AP-1 transcription factor network PID
SP1 pathway0000335 C-MYB transcription factor network PID
SP1 pathway0000608 Direct p53 effectors PID
SP1 pathway0000648 E2F transcription factor network PID
SP1 pathway0000658 EGFR1 NetPath
SP1 pathway0000824 FOXA1 transcription factor network PID
SP1 pathway0000825 FOXA2 and FOXA3 transcription factor networks PID
SP1 pathway0000826 FOXM1 transcription factor network PID
SP1 pathway0001021 HIF-1-alpha transcription factor network PID
SP1 pathway0001022 HIF-2-alpha transcription factor network PID
SP1 pathway0001046 Huntington disease PANTHER
SP1 pathway0001122 IL2 signaling events mediated by STAT5 PID
SP1 pathway0001127 IL4-mediated signaling events PID
SP1 pathway0001264 Leptin NetPath
SP1 pathway0001543 Oncogene Induced Senescence Reactome
SP1 pathway0001582 p73 transcription factor network PID
SP1 pathway0001704 PPARA activates gene expression Reactome
SP1 pathway0001849 Regulation of nuclear SMAD2/3 signaling PID
SP1 pathway0001861 Regulation of Telomerase PID
SP1 pathway0001921 RNA polymerase II transcribes snRNA genes Reactome
SP1 pathway0002069 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Reactome
SP1 pathway0002222 TGF_beta_Receptor NetPath
SP1 pathway0002391 Validated targets of C-MYC transcriptional repression PID
SP1 pathway0002392 Validated transcriptional targets of AP1 family members Fra1 and Fra2 PID
SP1 pathway0002394 Validated transcriptional targets of TAp63 isoforms PID
SP1 pathway0002591 TGF-beta signaling pathway KEGG
SP1 pathway0002642 Huntington's disease KEGG
SP1 pathway0002699 Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 WikiPathways
SP1 pathway0002712 Hs_Leptin_signaling_pathway_WP2034_89856 WikiPathways
SP1 pathway0002718 Hs_Interleukin-11_Signaling_Pathway_WP2332_79525 WikiPathways
SP1 pathway0002731 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 WikiPathways
SP1 pathway0002811 Hs_Estrogen_signaling_pathway_WP712_78491 WikiPathways
SP1 pathway0002812 Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 WikiPathways
SP1 pathway0002853 Hs_TGF-beta_Signaling_Pathway_WP366_90028 WikiPathways
SP1 pathway0002862 Hs_AGE-RAGE_pathway_WP2324_89798 WikiPathways
SP1 pathway0002863 Hs_Androgen_receptor_signaling_pathway_WP138_79958 WikiPathways
SP1 pathway0002866 Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 WikiPathways
SP3 pathway0001264 Leptin NetPath
SP3 pathway0001849 Regulation of nuclear SMAD2/3 signaling PID
SP3 pathway0001861 Regulation of Telomerase PID
SP3 pathway0002127 SUMOylation of transcription factors Reactome
SPI1 pathway0000335 C-MYB transcription factor network PID
SPI1 pathway0000702 ERK cascade ( FGF8 signaling (Mouse) ) INOH
SPI1 pathway0000703 ERK cascade ( FGF8 signaling (Xenopus) ) INOH
SPI1 pathway0000781 FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) INOH
SPI1 pathway0000782 FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) INOH
SPI1 pathway0000916 Glucocorticoid receptor regulatory network PID
SPI1 pathway0001127 IL4-mediated signaling events PID
SPI1 pathway0001128 IL4 NetPath
SPI1 pathway0001191 Interleukin signaling pathway PANTHER
SPI1 pathway0001799 RANKL NetPath
SPI1 pathway0001857 Regulation of retinoblastoma protein PID
SPI1 pathway0002391 Validated targets of C-MYC transcriptional repression PID
SPI1 pathway0002656 Pathways in cancer KEGG
SPI1 pathway0002668 Acute myeloid leukemia KEGG
SPI1 pathway0002874 Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016 WikiPathways
SPIC pathway0001191 Interleukin signaling pathway PANTHER
STAT3 pathway0000176 AndrogenReceptor NetPath
STAT3 pathway0000177 Angiogenesis PANTHER
STAT3 pathway0000226 Association of TriC/CCT with target proteins during biosynthesis Reactome
STAT3 pathway0000270 BCR NetPath
STAT3 pathway0000323 BMP2 signaling pathway(through Smad) ( TGF-beta_BMP Diagram(MolecularVariation) ) INOH
STAT3 pathway0000513 CXCR4-mediated signaling events PID
STAT3 pathway0000633 Downstream signal transduction Reactome
STAT3 pathway0000652 EGF receptor signaling pathway PANTHER
STAT3 pathway0000658 EGFR1 NetPath
STAT3 pathway0000688 EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) INOH
STAT3 pathway0000692 ErbB1 downstream signaling PID
STAT3 pathway0000695 ErbB2/ErbB3 signaling events PID
STAT3 pathway0000780 FGF signaling pathway PID
STAT3 pathway0000899 Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) INOH
STAT3 pathway0000900 Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) INOH
STAT3 pathway0000901 Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) INOH
STAT3 pathway0000966 GMCSF-mediated signaling events PID
STAT3 pathway0000976 Growth hormone receptor signaling Reactome
STAT3 pathway0001079 IFN-gamma pathway PID
STAT3 pathway0001081 IFN alpha signaling pathway(JAK1 TYK2 STAT1 STAT3) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) INOH
STAT3 pathway0001083 IFN alpha signaling pathway(JAK1 TYK2 STAT3) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) INOH
STAT3 pathway0001102 IL-10 signaling pathway(JAK1 TYK2 STAT3) ( IL-10 signaling(JAK1 TYK2 STAT3) ) INOH
STAT3 pathway0001106 IL-23 signaling pathway(JAK2 TYK2 STAT3 STAT4) ( IL-23 signaling(JAK2 TYK2 STAT3 STAT4) ) INOH
STAT3 pathway0001111 IL-6 signaling pathway(JAK1 JAK2 STAT3) ( IL-6 signaling(JAK1 JAK2 STAT3) ) INOH
STAT3 pathway0001112 IL-7 NetPath
STAT3 pathway0001115 IL1 NetPath
STAT3 pathway0001116 IL12-mediated signaling events PID
STAT3 pathway0001117 IL12 signaling mediated by STAT4 PID
STAT3 pathway0001119 IL2-mediated signaling events PID
STAT3 pathway0001120 IL2 NetPath
STAT3 pathway0001123 IL23-mediated signaling events PID
STAT3 pathway0001124 IL27-mediated signaling events PID
STAT3 pathway0001126 IL3 NetPath
STAT3 pathway0001128 IL4 NetPath
STAT3 pathway0001130 IL5 NetPath
STAT3 pathway0001131 IL6-mediated signaling events PID
STAT3 pathway0001132 IL6 NetPath
STAT3 pathway0001135 IL9 NetPath
STAT3 pathway0001147 Inflammation mediated by chemokine and cytokine signaling pathway PANTHER
STAT3 pathway0001188 Interleukin-6 signaling Reactome
STAT3 pathway0001191 Interleukin signaling pathway PANTHER
STAT3 pathway0001226 JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) INOH
STAT3 pathway0001228 JAK/STAT signaling pathway PANTHER
STAT3 pathway0001246 KitReceptor NetPath
STAT3 pathway0001264 Leptin NetPath
STAT3 pathway0001279 LIF signaling pathway ( LIF signaling(JAK1 JAK2 STAT3) ) INOH
STAT3 pathway0001479 Neurotrophic factor-mediated Trk receptor signaling PID
STAT3 pathway0001516 Notch-mediated HES/HEY network PID
STAT3 pathway0001517 Notch NetPath
STAT3 pathway0001604 PDGF signaling pathway PANTHER
STAT3 pathway0001606 PDGFR-beta signaling pathway PID
STAT3 pathway0001697 Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) INOH
STAT3 pathway0001701 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Reactome
STAT3 pathway0001727 Prolactin NetPath
STAT3 pathway0001788 RAC1 signaling pathway PID
STAT3 pathway0001805 Ras Pathway PANTHER
STAT3 pathway0001980 Senescence-Associated Secretory Phenotype (SASP) Reactome
STAT3 pathway0002010 Signaling by cytosolic FGFR1 fusion mutants Reactome
STAT3 pathway0002022 Signaling by Leptin Reactome
STAT3 pathway0002030 Signaling by SCF-KIT Reactome
STAT3 pathway0002033 Signaling events mediated by HDAC Class I PID
STAT3 pathway0002038 Signaling events mediated by PTP1B PID
STAT3 pathway0002039 Signaling events mediated by Stem cell factor receptor (c-Kit) PID
STAT3 pathway0002040 Signaling events mediated by TCPTP PID
STAT3 pathway0002301 Transcriptional regulation of pluripotent stem cells Reactome
STAT3 pathway0002354 TSH NetPath
STAT3 pathway0002355 TSLP NetPath
STAT3 pathway0002568 Chemokine signaling pathway KEGG
STAT3 pathway0002606 Jak-STAT signaling pathway KEGG
STAT3 pathway0002628 Adipocytokine signaling pathway KEGG
STAT3 pathway0002652 Toxoplasmosis KEGG
STAT3 pathway0002655 Hepatitis C KEGG
STAT3 pathway0002656 Pathways in cancer KEGG
STAT3 pathway0002659 Pancreatic cancer KEGG
STAT3 pathway0002668 Acute myeloid leukemia KEGG
STAT3 pathway0002682 Hs_Interferon_type_I_signaling_pathways_WP585_85198 WikiPathways
STAT3 pathway0002700 Hs_Signaling_of_Hepatocyte_Growth_Factor_Receptor_WP313_79946 WikiPathways
STAT3 pathway0002712 Hs_Leptin_signaling_pathway_WP2034_89856 WikiPathways
STAT3 pathway0002717 Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640 WikiPathways
STAT3 pathway0002718 Hs_Interleukin-11_Signaling_Pathway_WP2332_79525 WikiPathways
STAT3 pathway0002735 Hs_PDGF_Pathway_WP2526_82681 WikiPathways
STAT3 pathway0002743 Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 WikiPathways
STAT3 pathway0002746 Hs_Dopaminergic_Neurogenesis_WP2855_87239 WikiPathways
STAT3 pathway0002760 Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 WikiPathways
STAT3 pathway0002761 Hs_Amino_Acid_metabolism_WP3925_90737 WikiPathways
STAT3 pathway0002772 Hs_Vitamin_B12_Metabolism_WP1533_85340 WikiPathways
STAT3 pathway0002781 Hs_ESC_Pluripotency_Pathways_WP3931_91005 WikiPathways
STAT3 pathway0002786 Hs_MicroRNAs_in_cardiomyocyte_hypertrophy_WP1544_89794 WikiPathways
STAT3 pathway0002810 Hs_Regulation_of_Microtubule_Cytoskeleton_WP2038_90889 WikiPathways
STAT3 pathway0002829 Hs_Kit_receptor_signaling_pathway_WP304_78799 WikiPathways
STAT3 pathway0002837 Hs_IL-5_Signaling_Pathway_WP127_78498 WikiPathways
STAT3 pathway0002844 Hs_IL-2_Signaling_Pathway_WP49_91243 WikiPathways
STAT3 pathway0002858 Hs_IL-6_signaling_pathway_WP364_89832 WikiPathways
STAT3 pathway0002861 Hs_RalA_downstream_regulated_genes_WP2290_79988 WikiPathways
STAT3 pathway0002864 Hs_IL-4_Signaling_Pathway_WP395_89828 WikiPathways
STAT3 pathway0002865 Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803 WikiPathways
STAT3 pathway0002866 Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 WikiPathways
STAT3 pathway0002871 Hs_IL-3_Signaling_Pathway_WP286_78583 WikiPathways
STAT3 pathway0002873 Hs_Notch_Signaling_Pathway_WP61_78592 WikiPathways
STAT3 pathway0002879 Hs_IL-9_Signaling_Pathway_WP22_79264 WikiPathways
TCF3 pathway0000393 CDO in myogenesis Reactome
TCF3 pathway0001078 ID NetPath
TCF3 pathway0001516 Notch-mediated HES/HEY network PID
TCF3 pathway0001517 Notch NetPath
TCF3 pathway0001574 p38 signaling mediated by MAPKAP kinases PID
TCF3 pathway0001849 Regulation of nuclear SMAD2/3 signaling PID
TCF3 pathway0002439 Wnt NetPath
TCF3 pathway0002841 Hs_Ectoderm_Differentiation_WP2858_89329 WikiPathways
THRB pathway0001534 Nuclear Receptor transcription pathway Reactome
THRB pathway0001727 Prolactin NetPath
THRB pathway0001947 RXR and RAR heterodimerization with other nuclear receptor PID
THRB pathway0002570 Neuroactive ligand-receptor interaction KEGG
TRIM63 pathway0000184 Antigen processing: Ubiquitination & Proteasome degradation Reactome
TRIM63 pathway0002704 Hs_Factors_and_pathways_affecting_insulin-like_growth_factor_(IGF1)-Akt_signaling_WP3850_88165 WikiPathways
ZNF263 pathway0000905 Generic Transcription Pathway Reactome