General Details

Super-enhancer:SE_00_02600284
Genomic Locus: chr1: 155176461-155179811
Size/Length:3350bp
Conservation:0.187681
BioSample Type:Tissue
Tissue Type:Muscle of trunk
Sample Name:muscle-of-trunk
Source:Roadmap
Element:1
Rank:284
ChIP Density(Case):18365.035
ChIP Density(Input):608.36

Super-enhancer Associated Network


* The complex regulatory networks formed by this SE , SE associated genes , TFs binding to the SE and their upstream pathways can be interactively visualized.


Fimo:
SE-Gene Linking Strategies:
Pathway Enriciment Threshold:
Top Pathway:
 



Super-enhancer Associated Statistics

Associated Gene Details

ROSE Overlap:MTX1,THBS3
ROSE Proximal:GBA,MIR92B,KRTCAP2,TRIM46,MUC1,FAM189B,GBAP1
ROSE Closest:MTX1
The Closest Active:MTX1

Factors Binding to Super-enhancer




Using these SE element regions to analyze by online tools GREAT *The TFs binding to this SE identified by ChIP-seq.

Chrome Element_Start Element_End TF TF Source TF_Start TF_End TF Class Master TF

Using these SE element regions to analyze by online tools GREAT * The TFs binding to this SE predicted by Motif.

Chrome Element_Start Element_End TF Database TF_Start TF_End Score P_Value TF Class Master TF
chr1 155176461 155179811 BARHL1 Transfac.V$BARHL1_05 155179516 155179531 18.43640 2.31e-07 Helix-turn-helix domains N
chr1 155176461 155179811 BARHL1 Jolma2013.Barhl1_DBD_3 155179516 155179531 18.40400 2.25e-07 Helix-turn-helix domains N
chr1 155176461 155179811 BARHL2 Transfac.V$BARHL2_05 155179516 155179531 18.09090 4.04e-07 Helix-turn-helix domains N
chr1 155176461 155179811 BARHL2 Jolma2013.BARHL2_DBD_3 155179516 155179531 17.64860 2.23e-07 Helix-turn-helix domains N
chr1 155176461 155179811 BARHL2 Jolma2013.BARHL2_full_3 155179516 155179531 18.04550 3.96e-07 Helix-turn-helix domains N
chr1 155176461 155179811 CTCF Transfac.V$CTCF_01 155176798 155176817 17.85420 4.6e-07 Zinc-coordinating DNA-binding domains N
chr1 155176461 155179811 CTCF Transfac.V$CTCF_02 155176796 155176815 19.16420 1.03e-07 Zinc-coordinating DNA-binding domains N
chr1 155176461 155179811 CTCF JASPAR2014.MA0139.1 155176799 155176817 18.12900 4.43e-07 Zinc-coordinating DNA-binding domains N
chr1 155176461 155179811 EGR1 JASPAR2014.MA0162.2 155177191 155177204 17.80770 2.34e-07 Zinc-coordinating DNA-binding domains N
chr1 155176461 155179811 ETS1 Transfac.V$ETS1_03 155179008 155179025 13.69090 8.78e-07 Helix-turn-helix domains N
chr1 155176461 155179811 ETS1 Jolma2013.ETS1_DBD_2 155179008 155179025 16.72730 8.67e-07 Helix-turn-helix domains N
chr1 155176461 155179811 HOXD10 Transfac.V$HOXD10_01 155179746 155179762 17.40000 1.25e-07 Helix-turn-helix domains N
chr1 155176461 155179811 HOXD10 Homeodomain.UP00121_1 155179746 155179762 17.48000 1.14e-07 Helix-turn-helix domains N
chr1 155176461 155179811 HOXD10 Uniprobe.UP00121_1 155179746 155179762 17.48000 1.14e-07 Helix-turn-helix domains N
chr1 155176461 155179811 KLF5 Transfac.V$BTEB2_Q3 155178970 155178985 16.92000 3.08e-07 Zinc-coordinating DNA-binding domains N
chr1 155176461 155179811 MAX Transfac.V$MAX_Q6 155178662 155178673 16.49490 4.07e-07 Basic domains N
chr1 155176461 155179811 PATZ1 Transfac.V$MAZR_01 155177764 155177776 16.70330 8.9e-07 Zinc-coordinating DNA-binding domains N
chr1 155176461 155179811 PITX2 Transfac.V$PITX2_Q2 155176508 155176518 16.09090 8.91e-07 Helix-turn-helix domains N
chr1 155176461 155179811 PITX2 Transfac.V$PITX2_Q6 155176508 155176517 15.07070 9.1e-07 Helix-turn-helix domains N
chr1 155176461 155179811 POU1F1 Transfac.V$POU1F1_Q6 155179613 155179622 16.05050 7.98e-07 Helix-turn-helix domains N
chr1 155176461 155179811 RFX1 Transfac.V$EFC_Q6 155179672 155179685 16.74220 7.45e-07 Helix-turn-helix domains N
chr1 155176461 155179811 RFX1 Transfac.V$RFX1_02 155178535 155178552 17.31310 3.09e-07 Helix-turn-helix domains N
chr1 155176461 155179811 RFX1 JASPAR2014.MA0509.1 155178537 155178550 18.36210 2.82e-07 Helix-turn-helix domains N
chr1 155176461 155179811 RFX1 JASPAR2014.MA0509.1 155178537 155178550 18.89660 1.71e-07 Helix-turn-helix domains N
chr1 155176461 155179811 RFX2 Transfac.V$RFX2_01 155178536 155178551 17.66200 5.78e-07 Helix-turn-helix domains N
chr1 155176461 155179811 RFX2 Transfac.V$RFX2_01 155178536 155178551 17.28170 7.04e-07 Helix-turn-helix domains N
chr1 155176461 155179811 RFX2 Transfac.V$RFX2_03 155178536 155178551 17.74700 6.33e-07 Helix-turn-helix domains N
chr1 155176461 155179811 RFX2 Transfac.V$RFX2_03 155178536 155178551 17.39760 7.81e-07 Helix-turn-helix domains N
chr1 155176461 155179811 RFX2 JASPAR2014.MA0600.1 155178532 155178550 18.67240 2.59e-07 Helix-turn-helix domains N
chr1 155176461 155179811 RFX2 JASPAR2014.MA0600.1 155178537 155178555 20.50000 4.8e-08 Helix-turn-helix domains N
chr1 155176461 155179811 RFX2 Jolma2013.RFX2_DBD 155178536 155178551 17.63640 5.84e-07 Helix-turn-helix domains N
chr1 155176461 155179811 RFX2 Jolma2013.RFX2_DBD 155178536 155178551 17.26260 7.11e-07 Helix-turn-helix domains N
chr1 155176461 155179811 RFX2 Jolma2013.Rfx2_DBD 155178536 155178551 17.71000 6.38e-07 Helix-turn-helix domains N
chr1 155176461 155179811 RFX2 Jolma2013.Rfx2_DBD 155178536 155178551 17.36000 7.91e-07 Helix-turn-helix domains N
chr1 155176461 155179811 RFX3 Transfac.V$RFX3_06 155178536 155178551 18.12120 4.63e-07 Helix-turn-helix domains N
chr1 155176461 155179811 RFX3 Transfac.V$RFX3_06 155178536 155178551 18.36360 3.83e-07 Helix-turn-helix domains N
chr1 155176461 155179811 RFX3 Jolma2013.RFX3_DBD 155178536 155178551 18.10000 4.59e-07 Helix-turn-helix domains N
chr1 155176461 155179811 RFX3 Jolma2013.RFX3_DBD 155178536 155178551 18.34000 3.81e-07 Helix-turn-helix domains N
chr1 155176461 155179811 RFX4 Transfac.V$RFX4_05 155178536 155178551 17.10610 9.5e-07 Helix-turn-helix domains N
chr1 155176461 155179811 RFX4 Jolma2013.RFX4_DBD 155178536 155178551 17.10000 9.36e-07 Helix-turn-helix domains N
chr1 155176461 155179811 SP1 Transfac.V$SP1_Q6_02 155178966 155178982 14.07480 6.12e-07 Zinc-coordinating DNA-binding domains N
chr1 155176461 155179811 SP2 Transfac.V$SP2_Q3 155177743 155177757 16.76000 6.64e-07 Zinc-coordinating DNA-binding domains N
chr1 155176461 155179811 SP2 JASPAR2014.MA0516.1 155178969 155178983 17.51720 2.55e-07 Zinc-coordinating DNA-binding domains N
chr1 155176461 155179811 YBX1 Transfac.V$YB1_Q4 155177808 155177818 12.85710 2.43e-07 beta-Barrel DNA-binding domains N
chr1 155176461 155179811 YY1 Transfac.V$YY1_03 155179038 155179049 18.27780 4.92e-07 Zinc-coordinating DNA-binding domains N
chr1 155176461 155179811 YY1 JASPAR2014.MA0095.2 155179038 155179049 19.00000 6.49e-08 Zinc-coordinating DNA-binding domains N
chr1 155176461 155179811 ZFP42 Transfac.V$REX1_03 155179039 155179050 16.18180 5.03e-07 Zinc-coordinating DNA-binding domains N
chr1 155176461 155179811 ZNF263 JASPAR2014.MA0528.1 155179488 155179508 17.62000 5.33e-07 Zinc-coordinating DNA-binding domains N
chr1 155176461 155179811 ZNF263 JASPAR2014.MA0528.1 155179494 155179514 20.70000 3.8e-08 Zinc-coordinating DNA-binding domains N
chr1 155176461 155179811 ZNF263 JASPAR2014.MA0528.1 155179497 155179517 22.84000 4.2e-09 Zinc-coordinating DNA-binding domains N
chr1 155176461 155179811 ZNF423 Transfac.V$ROAZ_01 155177282 155177295 17.76770 9.47e-08 Zinc-coordinating DNA-binding domains N

The Upstream Pathways of TFs Binding to SE



TF Pathway ID Pathway Name Source
CTCF pathway0000061 Activation of anterior HOX genes in hindbrain development during early embryogenesis Reactome
CTCF pathway0002222 TGF_beta_Receptor NetPath
EGR1 pathway0000187 AP-1 transcription factor network PID
EGR1 pathway0000343 Calcineurin-regulated NFAT-dependent transcription in lymphocytes PID
EGR1 pathway0000634 Downstream signaling in naïve CD8+ T cells PID
EGR1 pathway0000692 ErbB1 downstream signaling PID
EGR1 pathway0000916 Glucocorticoid receptor regulatory network PID
EGR1 pathway0001180 Interferon alpha/beta signaling Reactome
EGR1 pathway0001825 Regulation of Androgen receptor activity PID
EGR1 pathway0002036 Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) PID
EGR1 pathway0002037 Signaling events mediated by PRL PID
EGR1 pathway0002199 TCR NetPath
EGR1 pathway0002339 Trk receptor signaling mediated by PI3K and PLC-gamma PID
EGR1 pathway0002340 Trk receptor signaling mediated by the MAPK pathway PID
EGR1 pathway0002643 Prion diseases KEGG
EGR1 pathway0002707 Hs_Thyroid_Stimulating_Hormone_(TSH)_signaling_pathway_WP2032_89823 WikiPathways
EGR1 pathway0002750 Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 WikiPathways
EGR1 pathway0002760 Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 WikiPathways
ETS1 pathway0000177 Angiogenesis PANTHER
ETS1 pathway0000178 Angiopoietin receptor Tie2-mediated signaling PID
ETS1 pathway0000187 AP-1 transcription factor network PID
ETS1 pathway0000271 BCR signaling pathway PID
ETS1 pathway0000335 C-MYB transcription factor network PID
ETS1 pathway0000702 ERK cascade ( FGF8 signaling (Mouse) ) INOH
ETS1 pathway0000703 ERK cascade ( FGF8 signaling (Xenopus) ) INOH
ETS1 pathway0000781 FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) INOH
ETS1 pathway0000782 FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) INOH
ETS1 pathway0001021 HIF-1-alpha transcription factor network PID
ETS1 pathway0001022 HIF-2-alpha transcription factor network PID
ETS1 pathway0001120 IL2 NetPath
ETS1 pathway0001127 IL4-mediated signaling events PID
ETS1 pathway0001128 IL4 NetPath
ETS1 pathway0001543 Oncogene Induced Senescence Reactome
ETS1 pathway0001604 PDGF signaling pathway PANTHER
ETS1 pathway0001805 Ras Pathway PANTHER
ETS1 pathway0002032 Signaling events mediated by focal adhesion kinase PID
ETS1 pathway0002036 Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) PID
ETS1 pathway0002222 TGF_beta_Receptor NetPath
ETS1 pathway0002408 VEGF signaling pathway PANTHER
ETS1 pathway0002588 Dorso-ventral axis formation KEGG
ETS1 pathway0002696 Hs_Apoptosis-related_network_due_to_altered_Notch3_in_ovarian_cancer_WP2864_79278 WikiPathways
ETS1 pathway0002743 Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 WikiPathways
ETS1 pathway0002747 Hs_Neural_Crest_Differentiation_WP2064_79263 WikiPathways
ETS1 pathway0002853 Hs_TGF-beta_Signaling_Pathway_WP366_90028 WikiPathways
ETS1 pathway0002877 Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900 WikiPathways
KLF5 pathway0002302 Transcriptional regulation of white adipocyte differentiation Reactome
KLF5 pathway0002758 Hs_TGF-beta_Receptor_Signaling_WP560_90187 WikiPathways
MAX pathway0000336 C-MYC pathway PID
MAX pathway0000515 Cyclin A:Cdk2-associated events at S phase entry Reactome
MAX pathway0000518 Cyclin E associated events during G1/S transition Reactome
MAX pathway0001560 Oxidative stress response PANTHER
MAX pathway0001849 Regulation of nuclear SMAD2/3 signaling PID
MAX pathway0001861 Regulation of Telomerase PID
MAX pathway0002033 Signaling events mediated by HDAC Class I PID
MAX pathway0002390 Validated targets of C-MYC transcriptional activation PID
MAX pathway0002391 Validated targets of C-MYC transcriptional repression PID
MAX pathway0002562 MAPK signaling pathway KEGG
MAX pathway0002656 Pathways in cancer KEGG
MAX pathway0002669 Small cell lung cancer KEGG
MAX pathway0002731 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 WikiPathways
MAX pathway0002757 Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 WikiPathways
MAX pathway0002877 Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900 WikiPathways
PATZ1 pathway0000176 AndrogenReceptor NetPath
PATZ1 pathway0000492 Coregulation of Androgen receptor activity PID
PATZ1 pathway0002863 Hs_Androgen_receptor_signaling_pathway_WP138_79958 WikiPathways
PITX2 pathway0001848 Regulation of nuclear beta catenin signaling and target gene transcription PID
PITX2 pathway0002591 TGF-beta signaling pathway KEGG
PITX2 pathway0002768 Hs_Heart_Development_WP1591_90186 WikiPathways
PITX2 pathway0002771 Hs_BMP_Signaling_Pathway_in_Eyelid_Development_WP3927_90735 WikiPathways
POU1F1 pathway0000916 Glucocorticoid receptor regulatory network PID
SP1 pathway0000069 Activation of gene expression by SREBF (SREBP) Reactome
SP1 pathway0000176 AndrogenReceptor NetPath
SP1 pathway0000187 AP-1 transcription factor network PID
SP1 pathway0000335 C-MYB transcription factor network PID
SP1 pathway0000608 Direct p53 effectors PID
SP1 pathway0000648 E2F transcription factor network PID
SP1 pathway0000658 EGFR1 NetPath
SP1 pathway0000824 FOXA1 transcription factor network PID
SP1 pathway0000825 FOXA2 and FOXA3 transcription factor networks PID
SP1 pathway0000826 FOXM1 transcription factor network PID
SP1 pathway0001021 HIF-1-alpha transcription factor network PID
SP1 pathway0001022 HIF-2-alpha transcription factor network PID
SP1 pathway0001046 Huntington disease PANTHER
SP1 pathway0001122 IL2 signaling events mediated by STAT5 PID
SP1 pathway0001127 IL4-mediated signaling events PID
SP1 pathway0001264 Leptin NetPath
SP1 pathway0001543 Oncogene Induced Senescence Reactome
SP1 pathway0001582 p73 transcription factor network PID
SP1 pathway0001704 PPARA activates gene expression Reactome
SP1 pathway0001849 Regulation of nuclear SMAD2/3 signaling PID
SP1 pathway0001861 Regulation of Telomerase PID
SP1 pathway0001921 RNA polymerase II transcribes snRNA genes Reactome
SP1 pathway0002069 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Reactome
SP1 pathway0002222 TGF_beta_Receptor NetPath
SP1 pathway0002391 Validated targets of C-MYC transcriptional repression PID
SP1 pathway0002392 Validated transcriptional targets of AP1 family members Fra1 and Fra2 PID
SP1 pathway0002394 Validated transcriptional targets of TAp63 isoforms PID
SP1 pathway0002591 TGF-beta signaling pathway KEGG
SP1 pathway0002642 Huntington's disease KEGG
SP1 pathway0002699 Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 WikiPathways
SP1 pathway0002712 Hs_Leptin_signaling_pathway_WP2034_89856 WikiPathways
SP1 pathway0002718 Hs_Interleukin-11_Signaling_Pathway_WP2332_79525 WikiPathways
SP1 pathway0002731 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 WikiPathways
SP1 pathway0002811 Hs_Estrogen_signaling_pathway_WP712_78491 WikiPathways
SP1 pathway0002812 Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 WikiPathways
SP1 pathway0002853 Hs_TGF-beta_Signaling_Pathway_WP366_90028 WikiPathways
SP1 pathway0002862 Hs_AGE-RAGE_pathway_WP2324_89798 WikiPathways
SP1 pathway0002863 Hs_Androgen_receptor_signaling_pathway_WP138_79958 WikiPathways
SP1 pathway0002866 Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 WikiPathways
YBX1 pathway0001120 IL2 NetPath
YBX1 pathway0001708 pre-mRNA splicing Reactome
YBX1 pathway0002038 Signaling events mediated by PTP1B PID
YBX1 pathway0002365 U12 Dependent Splicing Reactome
YBX1 pathway0002744 Hs_Selenium_Metabolism_and_Selenoproteins_WP28_71888 WikiPathways
YBX1 pathway0002865 Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803 WikiPathways
YY1 pathway0000061 Activation of anterior HOX genes in hindbrain development during early embryogenesis Reactome
YY1 pathway0000616 DNA Damage Recognition in GG-NER Reactome
YY1 pathway0000648 E2F transcription factor network PID
YY1 pathway0001400 mTOR signaling pathway PID
YY1 pathway0001516 Notch-mediated HES/HEY network PID
YY1 pathway0001517 Notch NetPath
YY1 pathway0001523 Notch signaling pathway PID
YY1 pathway0001579 p53 pathway PID
YY1 pathway0002033 Signaling events mediated by HDAC Class I PID
ZNF263 pathway0000905 Generic Transcription Pathway Reactome
ZNF423 pathway0000323 BMP2 signaling pathway(through Smad) ( TGF-beta_BMP Diagram(MolecularVariation) ) INOH
ZNF423 pathway0002755 Hs_White_fat_cell_differentiation_WP3946_90940 WikiPathways