General Details

Super-enhancer:SE_00_02600207
Genomic Locus: chr7: 100025492-100028947
Size/Length:3455bp
Conservation:0.190854
BioSample Type:Tissue
Tissue Type:Muscle of trunk
Sample Name:muscle-of-trunk
Source:Roadmap
Element:1
Rank:207
ChIP Density(Case):20312.2905
ChIP Density(Input):693.4185

Super-enhancer Associated Network


* The complex regulatory networks formed by this SE , SE associated genes , TFs binding to the SE and their upstream pathways can be interactively visualized.


Fimo:
SE-Gene Linking Strategies:
Pathway Enriciment Threshold:
Top Pathway:
 



Super-enhancer Associated Statistics

Associated Gene Details

ROSE Overlap:MEPCE,ZCWPW1
ROSE Proximal:C7orf47,TSC22D4,C7orf61
ROSE Closest:MEPCE
The Closest Active:MEPCE

Factors Binding to Super-enhancer




Using these SE element regions to analyze by online tools GREAT *The TFs binding to this SE identified by ChIP-seq.

Chrome Element_Start Element_End TF TF Source TF_Start TF_End TF Class Master TF

Using these SE element regions to analyze by online tools GREAT * The TFs binding to this SE predicted by Motif.

Chrome Element_Start Element_End TF Database TF_Start TF_End Score P_Value TF Class Master TF
chr7 100025492 100028947 EFNA2 Transfac.V$ELF1_Q6 100026583 100026594 16.99090 7.15e-07 UNKNOW N
chr7 100025492 100028947 EGR1 JASPAR2014.MA0162.2 100027992 100028005 17.00000 6.12e-07 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 EGR2 JASPAR2014.MA0472.1 100026362 100026376 16.77420 6.98e-07 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 GC Transfac.V$GC_01 100026838 100026851 16.66200 1.39e-07 UNKNOW N
chr7 100025492 100028947 KLF5 Transfac.V$BTEB2_Q3 100028067 100028082 16.12000 8.49e-07 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 MEF2A Transfac.V$MEF2A_05 100027247 100027258 17.68690 8.66e-07 alpha-Helices exposed by beta-structures N
chr7 100025492 100028947 MYEF2 Transfac.V$HMEF2_Q6 100027245 100027260 15.89090 6.48e-07 alpha-Helices exposed by beta-structures N
chr7 100025492 100028947 MYEF2 Transfac.V$MEF2_01 100027245 100027260 16.30650 4.31e-07 alpha-Helices exposed by beta-structures N
chr7 100025492 100028947 MYF5 Transfac.V$MYF5_Q6 100028676 100028688 17.10480 7.68e-07 Basic domains N
chr7 100025492 100028947 NRF1 Transfac.V$NRF1_02 100025939 100025950 19.56900 3.28e-07 Basic domains N
chr7 100025492 100028947 NRF1 Transfac.V$NRF1_02 100027321 100027332 18.68970 6.61e-07 Basic domains N
chr7 100025492 100028947 NRF1 Transfac.V$NRF1_Q6_01 100025940 100025950 17.60440 2.65e-07 Basic domains N
chr7 100025492 100028947 NRF1 JASPAR2014.MA0506.1 100025940 100025950 17.72730 5.43e-07 Basic domains N
chr7 100025492 100028947 NRF1 JASPAR2014.MA0506.1 100026982 100026992 17.96360 2.77e-07 Basic domains N
chr7 100025492 100028947 NRF1 Jolma2013.NRF1_full 100025939 100025950 19.51000 3.28e-07 Basic domains N
chr7 100025492 100028947 NRF1 Jolma2013.NRF1_full 100027321 100027332 18.63000 6.61e-07 Basic domains N
chr7 100025492 100028947 POU1F1 Transfac.V$POU1F1_03 100026802 100026818 19.95100 3.46e-09 Helix-turn-helix domains N
chr7 100025492 100028947 POU1F1 Transfac.V$POU1F1_03 100026804 100026820 17.38460 1.53e-07 Helix-turn-helix domains N
chr7 100025492 100028947 POU1F1 Jolma2013.POU1F1_DBD 100026802 100026818 19.87410 3.46e-09 Helix-turn-helix domains N
chr7 100025492 100028947 POU1F1 Jolma2013.POU1F1_DBD 100026804 100026820 17.31470 1.53e-07 Helix-turn-helix domains N
chr7 100025492 100028947 POU3F1 Transfac.V$POU3F1_03 100026805 100026816 15.71720 4.92e-07 Helix-turn-helix domains N
chr7 100025492 100028947 POU3F1 Jolma2013.POU3F1_DBD_2 100026805 100026816 15.67570 4.92e-07 Helix-turn-helix domains N
chr7 100025492 100028947 POU4F1 Transfac.V$POU4F1_01 100026804 100026817 18.01600 2.42e-07 Helix-turn-helix domains N
chr7 100025492 100028947 POU4F1 Transfac.V$POU4F1_01 100026805 100026818 19.11200 6.08e-08 Helix-turn-helix domains N
chr7 100025492 100028947 POU4F1 Jolma2013.POU4F1_DBD 100026804 100026817 17.96000 2.45e-07 Helix-turn-helix domains N
chr7 100025492 100028947 POU4F1 Jolma2013.POU4F1_DBD 100026805 100026818 19.05600 6.08e-08 Helix-turn-helix domains N
chr7 100025492 100028947 POU4F2 Transfac.V$POU4F2_01 100026805 100026820 19.63790 1.48e-07 Helix-turn-helix domains N
chr7 100025492 100028947 POU4F2 Jolma2013.POU4F2_DBD 100026802 100026817 18.65660 2.51e-07 Helix-turn-helix domains N
chr7 100025492 100028947 POU4F2 Jolma2013.POU4F2_DBD 100026805 100026820 20.48480 4.89e-08 Helix-turn-helix domains N
chr7 100025492 100028947 POU4F2 Jolma2013.POU4F2_full 100026802 100026817 16.29290 9.81e-07 Helix-turn-helix domains N
chr7 100025492 100028947 POU4F2 Jolma2013.POU4F2_full 100026805 100026820 19.80810 1.35e-07 Helix-turn-helix domains N
chr7 100025492 100028947 POU4F3 Transfac.V$POU4F3_02 100026802 100026817 19.78230 4.99e-08 Helix-turn-helix domains N
chr7 100025492 100028947 POU4F3 Transfac.V$POU4F3_02 100026805 100026820 20.72580 1.54e-08 Helix-turn-helix domains N
chr7 100025492 100028947 POU4F3 Jolma2013.POU4F3_DBD 100026802 100026817 19.71200 5.07e-08 Helix-turn-helix domains N
chr7 100025492 100028947 POU4F3 Jolma2013.POU4F3_DBD 100026805 100026820 20.65600 1.56e-08 Helix-turn-helix domains N
chr7 100025492 100028947 REL Transfac.V$CREL_Q6 100025536 100025547 15.15560 9.78e-07 TcoF-DB_TF N
chr7 100025492 100028947 SATB1 Transfac.V$SATB1_Q3 100026666 100026681 18.10000 5.7e-07 Helix-turn-helix domains N
chr7 100025492 100028947 SOX8 Transfac.V$SOX8_07 100028603 100028619 3.77632 8.36e-07 Other all-alpha-helical DNA-binding domains N
chr7 100025492 100028947 SP1 Transfac.V$SP1_02 100028071 100028081 16.77480 6.06e-07 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 SP1 Transfac.V$SP1_Q4_01 100026839 100026851 15.36360 8.73e-07 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 SP1 Transfac.V$SP1_Q4_01 100026922 100026934 16.41560 1.33e-07 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 SP1 Transfac.V$SP1_Q4_01 100028069 100028081 15.50650 6.53e-07 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 SP1 Transfac.V$SP1_Q6 100026839 100026851 16.10390 5.45e-07 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 SP1 Transfac.V$SP1_Q6 100026922 100026934 17.45450 5.85e-08 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 SP1 Transfac.V$SP1_Q6 100028069 100028081 16.38960 3.78e-07 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 SP1 Transfac.V$SP1_Q6_02 100028065 100028081 14.45790 3.5e-07 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 SP1 JASPAR2014.MA0079.3 100026840 100026850 16.17310 8.83e-07 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 SP1 JASPAR2014.MA0079.3 100026923 100026933 17.17310 3.03e-07 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 SP2 Transfac.V$SP2_Q3 100026922 100026936 16.86000 5.93e-07 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 SP2 Transfac.V$SP2_Q3 100028069 100028083 19.56000 9.67e-09 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 SP2 Transfac.V$SP2_Q3_01 100028067 100028081 18.91000 1.13e-08 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 SP2 JASPAR2014.MA0516.1 100026840 100026854 17.32760 3.41e-07 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 SP2 JASPAR2014.MA0516.1 100026919 100026933 17.60340 2.19e-07 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 SP2 JASPAR2014.MA0516.1 100027991 100028005 19.81030 3.71e-09 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 SP4 Transfac.V$SP4_03 100027990 100028006 18.90360 1.18e-08 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 SP4 Transfac.V$SP4_Q5 100026923 100026933 17.65000 3.03e-07 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 SP4 Transfac.V$SP4_Q5 100028070 100028080 16.85000 9.09e-07 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 SP4 Uniprobe.UP00002_1 100027990 100028006 18.74000 1.44e-08 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 SPI1 JASPAR2014.MA0080.3 100028242 100028256 16.91110 8.24e-07 Helix-turn-helix domains N
chr7 100025492 100028947 SPI1 Uniprobe.UP00085_1 100026583 100026596 15.19820 7.21e-07 Helix-turn-helix domains N
chr7 100025492 100028947 TAL1 Transfac.V$TAL1_Q6 100028636 100028645 15.41130 9.51e-07 Basic domains N
chr7 100025492 100028947 TBX18 Transfac.V$TBX18_01 100027097 100027115 3.53535 9.57e-07 Immunoglobulin fold N
chr7 100025492 100028947 TFAP2A Transfac.V$AP2_Q6_01 100027904 100027916 15.34000 7.57e-08 Basic domains N
chr7 100025492 100028947 WT1 Transfac.V$WT1_Q6_02 100028068 100028079 17.28570 1.55e-07 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 ZNF263 Transfac.V$FPM315_01 100027976 100027987 16.39390 9.59e-07 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 ZNF263 JASPAR2014.MA0528.1 100025508 100025528 17.96000 4.08e-07 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 ZNF263 JASPAR2014.MA0528.1 100027010 100027030 17.28000 6.93e-07 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 ZNF263 JASPAR2014.MA0528.1 100028700 100028720 17.58000 5.5e-07 Zinc-coordinating DNA-binding domains N
chr7 100025492 100028947 ZNF740 Transfac.V$ZFP740_03 100025547 100025562 15.69880 5.97e-07 Zinc-coordinating DNA-binding domains N

The Upstream Pathways of TFs Binding to SE



TF Pathway ID Pathway Name Source
EFNA2 pathway0000674 EPH-ephrin mediated repulsion of cells Reactome
EFNA2 pathway0000675 EPH-Ephrin signaling Reactome
EFNA2 pathway0000676 EPHA-mediated growth cone collapse Reactome
EFNA2 pathway0000677 EPHA forward signaling PID
EFNA2 pathway0002592 Axon guidance KEGG
EGR1 pathway0000187 AP-1 transcription factor network PID
EGR1 pathway0000343 Calcineurin-regulated NFAT-dependent transcription in lymphocytes PID
EGR1 pathway0000634 Downstream signaling in naïve CD8+ T cells PID
EGR1 pathway0000692 ErbB1 downstream signaling PID
EGR1 pathway0000916 Glucocorticoid receptor regulatory network PID
EGR1 pathway0001180 Interferon alpha/beta signaling Reactome
EGR1 pathway0001825 Regulation of Androgen receptor activity PID
EGR1 pathway0002036 Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) PID
EGR1 pathway0002037 Signaling events mediated by PRL PID
EGR1 pathway0002199 TCR NetPath
EGR1 pathway0002339 Trk receptor signaling mediated by PI3K and PLC-gamma PID
EGR1 pathway0002340 Trk receptor signaling mediated by the MAPK pathway PID
EGR1 pathway0002643 Prion diseases KEGG
EGR1 pathway0002707 Hs_Thyroid_Stimulating_Hormone_(TSH)_signaling_pathway_WP2032_89823 WikiPathways
EGR1 pathway0002750 Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 WikiPathways
EGR1 pathway0002760 Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 WikiPathways
EGR2 pathway0000061 Activation of anterior HOX genes in hindbrain development during early embryogenesis Reactome
EGR2 pathway0000343 Calcineurin-regulated NFAT-dependent transcription in lymphocytes PID
EGR2 pathway0001127 IL4-mediated signaling events PID
EGR2 pathway0002302 Transcriptional regulation of white adipocyte differentiation Reactome
EGR2 pathway0002394 Validated transcriptional targets of TAp63 isoforms PID
EGR2 pathway0002820 Hs_Fatty_Acid_Beta_Oxidation_WP143_79783 WikiPathways
GC pathway0002430 Vitamin D (calciferol) metabolism Reactome
GC pathway0002431 Vitamin D metabolism and pathway PANTHER
KLF5 pathway0002302 Transcriptional regulation of white adipocyte differentiation Reactome
KLF5 pathway0002758 Hs_TGF-beta_Receptor_Signaling_WP560_90187 WikiPathways
MEF2A pathway0000393 CDO in myogenesis Reactome
MEF2A pathway0000715 ERK/MAPK targets Reactome
MEF2A pathway0002044 Signaling mediated by p38-alpha and p38-beta PID
MEF2A pathway0002222 TGF_beta_Receptor NetPath
MEF2A pathway0002782 Hs_p38_MAPK_Signaling_Pathway_WP400_72084 WikiPathways
MYF5 pathway0000393 CDO in myogenesis Reactome
MYF5 pathway0001078 ID NetPath
MYF5 pathway0001848 Regulation of nuclear beta catenin signaling and target gene transcription PID
NRF1 pathway0001704 PPARA activates gene expression Reactome
NRF1 pathway0002299 Transcriptional activation of mitochondrial biogenesis Reactome
NRF1 pathway0002642 Huntington's disease KEGG
NRF1 pathway0002773 Hs_Energy_Metabolism_WP1541_91584 WikiPathways
NRF1 pathway0002823 Hs_Mitochondrial_Gene_Expression_WP391_71373 WikiPathways
POU1F1 pathway0000916 Glucocorticoid receptor regulatory network PID
POU4F1 pathway0000608 Direct p53 effectors PID
POU4F1 pathway0001864 Regulation of TP53 Activity through Association with Co-factors Reactome
POU4F1 pathway0002388 Validated nuclear estrogen receptor alpha network PID
POU4F2 pathway0000608 Direct p53 effectors PID
POU4F2 pathway0001864 Regulation of TP53 Activity through Association with Co-factors Reactome
POU4F2 pathway0002388 Validated nuclear estrogen receptor alpha network PID
REL pathway0000072 Activation of NF-kappaB in B cells Reactome
REL pathway0000196 Apoptosis signaling pathway PANTHER
REL pathway0000250 Atypical NF-kappaB pathway PID
REL pathway0000270 BCR NetPath
REL pathway0001115 IL1 NetPath
REL pathway0001264 Leptin NetPath
REL pathway0001799 RANKL NetPath
REL pathway0001825 Regulation of Androgen receptor activity PID
REL pathway0002199 TCR NetPath
REL pathway0002249 TNFalpha NetPath
REL pathway0002801 Hs_TNF_alpha_Signaling_Pathway_WP231_89895 WikiPathways
REL pathway0002868 Hs_T-Cell_antigen_Receptor_(TCR)_Signaling_Pathway_WP69_89937 WikiPathways
REL pathway0002870 Hs_IL-1_signaling_pathway_WP195_89932 WikiPathways
REL pathway0002877 Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900 WikiPathways
SATB1 pathway0000198 Apoptotic cleavage of cellular proteins Reactome
SATB1 pathway0000377 Caspase Cascade in Apoptosis PID
SP1 pathway0000069 Activation of gene expression by SREBF (SREBP) Reactome
SP1 pathway0000176 AndrogenReceptor NetPath
SP1 pathway0000187 AP-1 transcription factor network PID
SP1 pathway0000335 C-MYB transcription factor network PID
SP1 pathway0000608 Direct p53 effectors PID
SP1 pathway0000648 E2F transcription factor network PID
SP1 pathway0000658 EGFR1 NetPath
SP1 pathway0000824 FOXA1 transcription factor network PID
SP1 pathway0000825 FOXA2 and FOXA3 transcription factor networks PID
SP1 pathway0000826 FOXM1 transcription factor network PID
SP1 pathway0001021 HIF-1-alpha transcription factor network PID
SP1 pathway0001022 HIF-2-alpha transcription factor network PID
SP1 pathway0001046 Huntington disease PANTHER
SP1 pathway0001122 IL2 signaling events mediated by STAT5 PID
SP1 pathway0001127 IL4-mediated signaling events PID
SP1 pathway0001264 Leptin NetPath
SP1 pathway0001543 Oncogene Induced Senescence Reactome
SP1 pathway0001582 p73 transcription factor network PID
SP1 pathway0001704 PPARA activates gene expression Reactome
SP1 pathway0001849 Regulation of nuclear SMAD2/3 signaling PID
SP1 pathway0001861 Regulation of Telomerase PID
SP1 pathway0001921 RNA polymerase II transcribes snRNA genes Reactome
SP1 pathway0002069 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Reactome
SP1 pathway0002222 TGF_beta_Receptor NetPath
SP1 pathway0002391 Validated targets of C-MYC transcriptional repression PID
SP1 pathway0002392 Validated transcriptional targets of AP1 family members Fra1 and Fra2 PID
SP1 pathway0002394 Validated transcriptional targets of TAp63 isoforms PID
SP1 pathway0002591 TGF-beta signaling pathway KEGG
SP1 pathway0002642 Huntington's disease KEGG
SP1 pathway0002699 Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 WikiPathways
SP1 pathway0002712 Hs_Leptin_signaling_pathway_WP2034_89856 WikiPathways
SP1 pathway0002718 Hs_Interleukin-11_Signaling_Pathway_WP2332_79525 WikiPathways
SP1 pathway0002731 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 WikiPathways
SP1 pathway0002811 Hs_Estrogen_signaling_pathway_WP712_78491 WikiPathways
SP1 pathway0002812 Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 WikiPathways
SP1 pathway0002853 Hs_TGF-beta_Signaling_Pathway_WP366_90028 WikiPathways
SP1 pathway0002862 Hs_AGE-RAGE_pathway_WP2324_89798 WikiPathways
SP1 pathway0002863 Hs_Androgen_receptor_signaling_pathway_WP138_79958 WikiPathways
SP1 pathway0002866 Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 WikiPathways
SPI1 pathway0000335 C-MYB transcription factor network PID
SPI1 pathway0000702 ERK cascade ( FGF8 signaling (Mouse) ) INOH
SPI1 pathway0000703 ERK cascade ( FGF8 signaling (Xenopus) ) INOH
SPI1 pathway0000781 FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) INOH
SPI1 pathway0000782 FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) INOH
SPI1 pathway0000916 Glucocorticoid receptor regulatory network PID
SPI1 pathway0001127 IL4-mediated signaling events PID
SPI1 pathway0001128 IL4 NetPath
SPI1 pathway0001191 Interleukin signaling pathway PANTHER
SPI1 pathway0001799 RANKL NetPath
SPI1 pathway0001857 Regulation of retinoblastoma protein PID
SPI1 pathway0002391 Validated targets of C-MYC transcriptional repression PID
SPI1 pathway0002656 Pathways in cancer KEGG
SPI1 pathway0002668 Acute myeloid leukemia KEGG
SPI1 pathway0002874 Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016 WikiPathways
TFAP2A pathway0000377 Caspase Cascade in Apoptosis PID
TFAP2A pathway0002699 Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 WikiPathways
TFAP2A pathway0002747 Hs_Neural_Crest_Differentiation_WP2064_79263 WikiPathways
TFAP2A pathway0002841 Hs_Ectoderm_Differentiation_WP2858_89329 WikiPathways
TFAP2A pathway0002849 Hs_Hypothetical_Craniofacial_Development_Pathway_WP3655_88473 WikiPathways
WT1 pathway0000318 BMP signaling in Drosophila ( BMP signaling in Drosophila ) INOH
WT1 pathway0000319 BMP signaling in Drosophila (dorsal midline) ( BMP signaling in Drosophila ) INOH
WT1 pathway0000320 BMP signaling in Drosophila (dorsolateral) ( BMP signaling in Drosophila ) INOH
WT1 pathway0000321 BMP signaling pathway ( TGF-beta_BMP Diagram(MolecularVariation) ) INOH
WT1 pathway0001582 p73 transcription factor network PID
WT1 pathway0001861 Regulation of Telomerase PID
WT1 pathway0002218 TGF-beta_super_family_signaling_pathway(canonical) ( TGF-beta_BMP Diagram(MolecularVariation) ) INOH
ZNF263 pathway0000905 Generic Transcription Pathway Reactome
ZNF740 pathway0000905 Generic Transcription Pathway Reactome