Enhancer ID: | E_02_312 | |
Enhancer symbol: | -- | |
Species: | Mouse | |
Position : | chr11:100859351-100885169 |
|
Biosample name: | Mammary Epithelium | |
Experiment class : | Low+High throughput |
Enhancer type: | Enhancer | |
Disease: | -- | |
DO: | -- | |
Mesh: | -- | |
Distance from TSS: | -- | |
Pubmed ID: | 26446995 |
Enhancer experiment: | PCR,ChIP-seq,RT-PCR,DNase-seq | |
Enhancer experiment description: | MED1 binding coincided with STAT5 occupancy. RNA Pol II binding also coincided with these sequences. |
Target gene : | Stat5 | |
Strong evidence: | -- | |
Less strong evidence: | PCR,ChIP-seq,RT-PCR,DNase-seq | |
Target gene experiment description: | MED1 binding coincided with STAT5 occupancy. RNA Pol II binding also coincided with these sequences. |
TF name : | -- | |
TF experiment: | -- | |
TF experiment description: | -- |
Enhancer function : | Transcriptome analysis identified a class of mammary-restricted genes that was particularly dependent on high STAT5 levels as a result of the intergenic enhancer. |
Enhancer function experiment: | CRISPR/Cas9 |
Enhancer function experiment description: |
Taken together, the mammary_x0002_specific enhancer enables a positive feedback cir_x0002_cuit that contributes to the remarkable abundance of STAT5 and, in turn, to the efficacy of STAT5-dependent mammary physiology. |
SNP ID: | -- | |
SNP position: | -- |
SNP experiment: | -- |
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