About Enhancer

Enhancer ID: E_02_293
Enhancer symbol:
Species: Mouse
Position : chr7:103771431-103772043
Biosample name: Pleen Cells,MEL cells
Experiment class : Low throughput
Enhancer type: Enhancer
Disease: --
DO: --
Mesh: --
Distance from TSS: >2kb
Pubmed ID:  12861010
Enhancer experiment: PCR,DNaseI-seq
Enhancer experiment description: We have also found DNase I HSs at kb -85.5 (HS-85.5) and -84.5 in mouse, but there is no corresponding se_x0002_quence or structure in human for these HSs.By comparison,neither the active _x0002_maj-globin gene promoter nor a region located ~1 kb from HS5 shows significant enrichment. HS-85.5 exhibits a modest (twofold) enrichment.

About Target gene

Target gene : Hbb-ar(Hbb-lcr)
Strong evidence: --
Less strong evidence: DNaseI-seq,Southern blot,PCR
Target gene experiment description: In ery_x0002_throid cells, the active _x0002_-globin locus contains several DNase I HSs, which have been shown to map to sequences with regu_x0002_latory function.In addition, histone hyperacetylation and dimethylation of histone H3 K4 are not uniform features of the nuclease-sensitive mouse _x0001_-globin domain but rather define distinct subdomains within it. Our results reveal a complex chromatin landscape for the active _x0001_-globin locus and illustrate the complexity of broad structural changes that accompany gene activation.

About TF

TF name : Ctcf(MRD21)
TF experiment: ChIP
TF experiment description: To determine whether CTCF binds to these sequences in vivo, we performed ChIP analysis using antibodies to CTCF.

About Function

Enhancer function : --
Enhancer function experiment: --
Enhancer function
experiment description:
--

About SNP

SNP ID: --
SNP position: --
SNP experiment: --

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer


Enhancer associated SNPs