About Enhancer
| Enhancer ID: | E_02_288 | |
| Enhancer symbol: | ||
| Species: | Mouse | |
| Position : | chr2:129350852-129356319   |
|
| Biosample name: | Macrophage | |
| Experiment class : | Low+High throughput |
| Enhancer type: | enhancer | |
| Disease: | -- | |
| DO: | -- | |
| Mesh: | -- | |
| Distance from TSS: | -- | |
| Pubmed ID: | 26912657 |
| Enhancer experiment: | ChIP-qPCR,ChIP-seq | |
| Enhancer experiment description: | Based on the ENCODE/UCSDbonemarrow-derivedmacrophageH3K27Ac chromatin immunoprecipitation sequencing (ChIP-seq) database, two peaks of DNA sequencing frequency were found in area, -10 kb (peak 1) and -2 kb (peak 2) upstream of the pro-IL-1beta transcription start site (TSS) (Fig. 4A). These peaks also coincided with the genomic regions highly associated with H3K4me1 but not with H3Kme3, indicating active enhancers. |
About Target gene
| Target gene : | Il1b(IL-1,IL1-BETA,IL1F2,IL1beta) | |
| Strong evidence: | -- | |
| Less strong evidence: | qPCR | |
| Target gene experiment description: | Therefore, we designed 11 qPCR primer sets encom-passing the genomic area to analyze the production of pro-IL-1 beta -associated eRNAs.These results suggest that the production of peak 2 eRNA was required for the optimal production of pro-IL-1beta mRNA. |
About TF
| TF name : | -- | |
| TF experiment: | -- | |
| TF experiment description: | -- |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
