About Enhancer

Enhancer ID: E_02_278
Enhancer symbol: miR-1 SE(M1)
Species: Mouse
Position : chr2:180361998-180364335
Biosample name: myotubes
Experiment class : Low+High throughput
Enhancer type: Enhancer
Disease: --
DO: --
Mesh: --
Distance from TSS: --
Pubmed ID:  26855180
Enhancer experiment: CRISPR/Cas9,RT-qPCR
Enhancer experiment description: In the C2C12 cell line, a model for myotube differentiation, SE was only observed for one of the two miR-1 genes (miR-1a-1/133a-2) and myotube differentiation strongly induced primary miRNAs of only this miRNA gene (Fig-ure S5B).Deletion of all four constituents of miR-1 SE dramatically suppressed induction of miR-1 and miR-133 and myogenic differentiationmarkers such asMyogenin andmuscle creatine kinase (MCK), phenocopying miR-1 knockdown phenotype (Chen et al., 2006)(Figures 4C and4D and S5C).

About Target gene

Target gene : MiR-1a-1(Mir1-1,Mirn1b,Mirn1c,Mirn1d,Mirn1-1,mir-1a-1,mmu-mir-1-1,mmu-mir-1a-1),MiR-133a-2(Mirn133a-2,mir-133a-2)
Strong evidence: CRISPR/Cas9
Less strong evidence: RT-qPCR
Target gene experiment description: In the C2C12 cell line, a model for myotube differentiation, SE was only observed for one of the two miR-1 genes (miR-1a-1/133a-2) and myotube differentiation strongly induced primary miRNAs of only this miRNA gene (Fig-ure S5B).Deletion of all four constituents of miR-1 SE dramatically suppressed induction of miR-1 and miR-133 and myogenic differentiationmarkers such asMyogenin andmuscle creatine kinase (MCK), phenocopying miR-1 knockdown phenotype (Chen et al., 2006)(Figures 4C and4D and S5C).

About TF

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TF experiment: --
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About Function

Enhancer function : --
Enhancer function experiment: --
Enhancer function
experiment description:
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About SNP

SNP ID: --
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Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer


Enhancer associated SNPs