Enhancer ID: | E_02_273 | |
Enhancer symbol: | miR-290-295 SE (E3) | |
Species: | Mouse | |
Position : | chr7:3205726-3207280 |
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Biosample name: | Embryonic Stem Cell | |
Experiment class : | Low+High throughput |
Enhancer type: | Enhancer | |
Disease: | -- | |
DO: | -- | |
Mesh: | -- | |
Distance from TSS: | -- | |
Pubmed ID: | 26855180 |
Enhancer experiment: | CRISPR/Cas9,RT-qPCR | |
Enhancer experiment description: | Among seven constituents of miR-290-295 SE (E1-E7, Figure 4A), deletion of individual elements except for E6 led to substantial decrease (ranging from 50% to 80%) in de novo production of mature miRNAs in TT-FHAgo2 mESC background without concomitant changes in other miRNA production (Figures 4Band S5A). A 5-fold reduction in expression upon deletion of one constituent of a group of six indicates cooperative interactions.As expected from a decrease in these miRNAs, these deletions also suppressed expression of Ago2-inducible gene Lin28a, a regulator of ES cells (Figure 4B). |
Target gene : | MiR-290(Mirn290,mir-290a,mmu-miR-290,mmu-mir-290a),291a,292,291b,293,294,295-295 | |
Strong evidence: | CRISPR/Cas9 | |
Less strong evidence: | RT-qPCR | |
Target gene experiment description: | Among seven constituents of miR-290-295 SE (E1-E7, Figure 4A), deletion of individual elements except for E6 led to substantial decrease (ranging from 50% to 80%) in de novo production of mature miRNAs in TT-FHAgo2 mESC background without concomitant changes in other miRNA production (Figures 4Band S5A). A 5-fold reduction in expression upon deletion of one constituent of a group of six indicates cooperative interactions.As expected from a decrease in these miRNAs, these deletions also suppressed expression of Ago2-inducible gene Lin28a, a regulator of ES cells (Figure 4B). |
TF name : | -- | |
TF experiment: | -- | |
TF experiment description: | -- |
Enhancer function : | -- |
Enhancer function experiment: | -- |
Enhancer function experiment description: |
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SNP ID: | -- | |
SNP position: | -- |
SNP experiment: | -- |
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