About Enhancer

Enhancer ID: E_02_260
Enhancer symbol: --
Species: Mouse
Position : chr12:35841201-35921783
Biosample name: ST2
Experiment class : Low+High throughput
Enhancer type: Super-Enhancer
Disease: --
DO: --
Mesh: --
Distance from TSS: >2KB
Pubmed ID:  30544251
Enhancer experiment: ChIP-seq
Enhancer experiment description: The four adjacent merged SEs (SE283,SE284,SE285,and SE286) at the Ahr locus together cover a continuous region over 300 kb of active enhancer signal downstream of the Ahr gene in the ST2 cells.Moreover, all four SEs showed a very high correlation (r ≥ 0.95) with Ahr mRNA levels as measured by RNA-seq (Figure 5C and D, upper panels) and validated by RT-qPCR.

About Target gene

Target gene : Ahr(Ah,Ahhe,In,bHLHe76,Ahr)
Strong evidence: --
Less strong evidence: RT-qPCR,ChIP,RNA-seq
Target gene experiment description: Ahr is regulated by multiple SEs with lineage-specific dynamics The Ahr mRNA level was measured across the differentiation by RNA-seq and RT-qPCR in both adipocyte and osteoblast differentiation and is indicated astheintactline.

About TF

TF name : Ahr(RP85,bHLHe76)Glis1(Gli5,Gli6,GliH1)
TF experiment: RT-qPCR
TF experiment description: To confirm the observed differentiation defects in the presence of high AHR and GLIS1 levels, RT-qPCR analysis of the known adipocyte marker gene Lpl was performed. In ST2-TetOn-GFP cells Lpl was upregulated by D5 of differentiation and remained elevated in D9 cells both in presence and absence of doxycycline.

About Function

Enhancer function : --
Enhancer function experiment: --
Enhancer function
experiment description:
--

About SNP

SNP ID: --
SNP position: --
SNP experiment: --

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer


Enhancer associated SNPs