Enhancer ID: | E_02_260 | |
Enhancer symbol: | -- | |
Species: | Mouse | |
Position : | chr12:35841201-35921783 |
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Biosample name: | ST2 | |
Experiment class : | Low+High throughput |
Enhancer type: | Super-Enhancer | |
Disease: | -- | |
DO: | -- | |
Mesh: | -- | |
Distance from TSS: | >2KB | |
Pubmed ID: | 30544251 |
Enhancer experiment: | ChIP-seq | |
Enhancer experiment description: | The four adjacent merged SEs (SE283,SE284,SE285,and SE286) at the Ahr locus together cover a continuous region over 300 kb of active enhancer signal downstream of the Ahr gene in the ST2 cells.Moreover, all four SEs showed a very high correlation (r ≥ 0.95) with Ahr mRNA levels as measured by RNA-seq (Figure 5C and D, upper panels) and validated by RT-qPCR. |
Target gene : | Ahr(Ah,Ahhe,In,bHLHe76,Ahr) | |
Strong evidence: | -- | |
Less strong evidence: | RT-qPCR,ChIP,RNA-seq | |
Target gene experiment description: | Ahr is regulated by multiple SEs with lineage-specific dynamics The Ahr mRNA level was measured across the differentiation by RNA-seq and RT-qPCR in both adipocyte and osteoblast differentiation and is indicated astheintactline. |
TF name : | Ahr(RP85,bHLHe76)Glis1(Gli5,Gli6,GliH1) | |
TF experiment: | RT-qPCR | |
TF experiment description: | To confirm the observed differentiation defects in the presence of high AHR and GLIS1 levels, RT-qPCR analysis of the known adipocyte marker gene Lpl was performed. In ST2-TetOn-GFP cells Lpl was upregulated by D5 of differentiation and remained elevated in D9 cells both in presence and absence of doxycycline. |
Enhancer function : | -- |
Enhancer function experiment: | -- |
Enhancer function experiment description: |
-- |
SNP ID: | -- | |
SNP position: | -- |
SNP experiment: | -- |
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